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<div id="navigation"> <div id="menu" style="position:static"> <ul> <li><a class="aMain" href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo">Home</a></li> <li><a class="aTeam" href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Team/Students">Team</a></li> <li><a class="aProject" href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Project">Project</a>  <li><font color="#ffffff">Results</font> <ul> <li><a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Project/Results">Experiments</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Project/Simulations">Simulations</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Achievements/DNA_Devices">DNA Design</a></li> </ul></li>  <li><a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Project/Achievements">Achievements</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Project/Future_works">Future works</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Notebook/Protocols">Protocols</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Notebook/Lab.notebook">Notes</a></li> <li><a class="aNotebook" href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Sponsors/">Sponsors</a></li> <li><a class="aSitemap" href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Sitemap">Sitemap</a></li>

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TeamJapan Tokyo developed an autonomous micrometer-sized molecular robot, “DNA ciliate”, toward the construction of a highly functional molecular robot like a living cell.

Project overview

A living cell is an ultimate highly functional molecular robot. The high functionality results from not only its various functional molecules but also its “micrometer-sized” body that has enough space to possess the molecules. However, the sizes of already-developed molecular nanomachines are too small to include many functional molecules. Toward the construction of highly functional molecular machines and molecular robots, it is required to construct molecular robots with large (i.e., micrometer-sized) bodies. Here, we propose an autonomous micrometer-sized molecular robot “DNA ciliate”.

<html><body> <iframe width="450" height="263" src="http://www.youtube.com/embed/aze2N57tcng" frameborder="0" allowfullscreen></iframe> <br><center>This is our YouTube video.</center> </body></html>

<html> <a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Project"><img src="http://openwetware.org/images/2/2c/Biomod2011_Team_Tokyo_111101Biomod_three_mode_02_R.jpg" border=1 width="470" height="353"></a><br> <font size="3" color="#000066"><i><strong> <font size="3" color="#009933">“DNA ciliate”</font>is an autonomous micrometer-sized molecular robot that has three independent functional modes. </strong></i></font><br><br> </html>

DNA ciliate

“DNA ciliate” is an autonomous micrometer-sized molecular robot, which is inspired by water microorganisms, ciliates. A natural ciliate has a micrometer-sized body with cilia and achieves various functions such as autonomous motion with the cilia, phototaxis, etc. Similarly, the DNA ciliate has a micrometer-sized body with many DNAs as cilia, and it can switch three different modes in response to its external environment: the free moving mode, the track walking mode, and the light-irradiated gathering mode. (See below)

Three independent functional modes of DNA ciliate

The DNA ciliate can move around in a broad range of space using the free moving mode. This mode utilizes the Brownian motion of the DNA ciliate.
See more

In the track walking mode, the DNA ciliate walk directionally along a single-stranded DNA track on a plate using the cleaving activity of deoxyribozymes attached on the body of the DNA ciliate. The deoxyribozymes cleave substrate DNA strands arrayed as the track, and help the DNA ciliate move to the region of uncleaved substrate DNA step-by-step.
See more

The DNA ciliates gather at a specific area where an ultraviolet (UV) light is irradiated; this is the light-irradiated gathering mode. To achieve this mode, a UV-switching DNA system based on the cis-trans isomerization of azobenzenes was designed.
See more

@@ Line 1: / Line 1: @@
 {{HEAD_1}}
 __NOTOC__
-<br>
-<br>
+:<br><i>TeamJapan Tokyo developed an autonomous micrometer-sized molecular robot, “DNA ciliate”, toward the construction of a highly functional molecular robot like a living cell.</i><br><br>
-<br>
-<br>
-<br>
-<br>
-<br>
-<!--この上の呪文たちは必ず各ページのコピペすること-->
 =Project overview=
-<HTML><body><table width="100%"><tr><td width="500px" valign="top" style="padding-left:20px">
+<table width="100%">
-<br><i>TeamJapan Tokyo developed an autonomous micrometer-sized molecular robot, “DNA ciliate”, toward the construction of a highly functional molecular robot like a living cell.</i><br><br>
+ <tr valign="top">
-&nbsp;A living cell is an ultimate highly functional molecular robot. The high functionality results from not only its various functional molecules but also its “micrometer-sized” body that has enough space to possess the molecules. However, the sizes of already-developed molecular nanomachines are too small to include many functional molecules. Toward the construction of highly functional molecular machines and molecular robots, it is required to construct molecular robots with large (i.e., micrometer-sized) bodies. Here, we propose an autonomous micrometer-sized molecular robot “DNA ciliate”. A natural ciliate has a micrometer-sized body with cilia and achieves various functions such as autonomous motion with the cilia, phototaxis, etc. <b>DNA ciliate has a micrometer-sized body with many DNAs as cilia</b>, and it can switch three different modes in response to its external environment: <b>the free moving mode, the track walking mode, and the light-irradiated gathering mode</b>. (See below.)
+  <td width="450px" style="padding-left: 20px">
-</td><td align="center" valign="top">
+&nbsp;&nbsp;A living cell is an ultimate highly functional molecular robot. The high functionality results from not only its various functional molecules but also its “micrometer-sized” body that has enough space to possess the molecules. However, the sizes of already-developed molecular nanomachines are too small to include many functional molecules. Toward the construction of highly functional molecular machines and molecular robots, it is required to construct molecular robots with large (i.e., micrometer-sized) bodies. Here, we propose an autonomous micrometer-sized molecular robot “DNA ciliate”.
-<a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Project"><img src="http://openwetware.org/images/2/2c/Biomod2011_Team_Tokyo_111101Biomod_three_mode_02_R.jpg" border=1 width="350" height="263"></a><br>
+  </td>
-   <font size="3" color="#000066"><i><strong>
+  <td width="450px" style="padding-left: 20px">
-<font size="3" color="#00ff66">“DNA ciliate”</font>is an autonomous micrometer-sized molecular robot that has three independent functional modes.
+<HTML><body>
-</strong></i></font><br><br><iframe width="350" height="263" src="http://www.youtube.com/embed/uejCuQWG07A" frameborder="0" allowfullscreen></iframe>
+<iframe width="450" height="263" src="http://www.youtube.com/embed/aze2N57tcng" frameborder="0" allowfullscreen></iframe>
- </td>
+<br><center>This is our YouTube video.</center>
+</body></HTML>
+  </td>
   </tr>
+ <tr>
+  <td align="center"><!--valign="top"-->
+<HTML>
+<a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Project"><img src="http://openwetware.org/images/2/2c/Biomod2011_Team_Tokyo_111101Biomod_three_mode_02_R.jpg" border=1 width="470" height="353"></a><br>
+<font size="3" color="#000066"><i><strong>
+<font size="3" color="#009933">“DNA ciliate”</font>is an autonomous micrometer-sized molecular robot that has three independent functional modes.
+</strong></i></font><br><br>
+</HTML>
+  </td>
+  <td style="padding-left: 30px">
+==DNA ciliate==
+<HTML><Center>
+<a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Project#The_body_of_the_DNA_ciliate"><img
+src="http://openwetware.org/images/8/8c/DNA_ciliate_body.jpg" border=1 width="250px"></a>
+</Center></HTML>
+“DNA ciliate” is an autonomous micrometer-sized molecular robot, which is inspired by water microorganisms, ciliates. A natural ciliate has a micrometer-sized body with cilia and achieves various functions such as autonomous motion with the cilia, phototaxis, etc. Similarly,<B> the DNA ciliate has a micrometer-sized body with many DNAs as cilia</B>, and it can<B> switch three different modes</B> in response to its external environment:<B> the free moving mode, the track walking mode, and the light-irradiated gathering mode.</B> (See below)
+  </td>
+ </tr>
 </table>
-</body></HTML>
-==DNA ciliate body==
+==Three independent functional modes of DNA ciliate==
-{|
-|-
-|width="280px"|[[Image:DNA ciliate body.jpg|right|250px|DNA ciliates'body]]
-|
-:To create DNA ciliate, a micrometer-sized body and its motor are indispensable. We chose DNA as a material for the motor because DNA is the most suitable material that is nanometer-sized and easy to be attached to micrometer-sized objects by various surface modifications. The micrometer-sized body is required to be micrometer-sized, homogeneous, and easy to attach DNA.
-|}
 <table width="100%">
-<tr>
+<tr align="center" style="padding-left: 10px">
-<td>
+<HTML>
-[[Image:Biomod2011 Team Tokyo 111101Biomod FreeMovingMode 3 title.gif|300px|center]]</td>
+ <td style="padding: 0px 10px">
-<td>
+<a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Project#1._Free_moving_mode"><img src="http://openwetware.org/images/d/d4/Biomod2011_Team_Tokyo_111101Biomod_FreeMovingMode_3_title.gif" border=1 width="300"></a>
-[[Image:Biomod2011 Team Tokyo 111101Biomod TrackWalkingMode 3 title.gif|300px|center]]</td>
+ </td>
-<td>
+ <td style="padding: 0px 10px">
-[[Image:Biomod2011 Team Tokyo 111101Biomod Right-irradiatedGatheringMode 3 title.gif|300px|center]]</td>
+<a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Project#2._Track_walking_mode"><img src="http://openwetware.org/images/a/a5/Biomod2011_Team_Tokyo_111101Biomod_TrackWalkingMode_3_title.gif" border=1 width="300"></a>
+ </td>
+ <td style="padding: 0px 10px">
+<a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Project#3._Light-irradiated_gathering_mode"><img src="http://openwetware.org/images/9/9e/Biomod2011_Team_Tokyo_111101Biomod_Right-irradiatedGatheringMode_3_title.gif" border=1 width="300"></a>
+ </td>
+</HTML>
+</tr>
+<tr valign="top" align="center">
+<td style="padding: 0px 10px">
+The DNA ciliate can move around in a broad range of space using the free moving mode. This mode utilizes the Brownian motion of the DNA ciliate.
+<br>[[Biomod/2011/TeamJapan/Tokyo/Project#1. Free moving mode|See more]]
+</td>
+<td style="padding: 0px 10px">
+In the track walking mode, the DNA ciliate walk directionally along a single-stranded DNA track on a plate using the cleaving activity of deoxyribozymes attached on the body of the DNA ciliate. The deoxyribozymes cleave substrate DNA strands arrayed as the track, and help the DNA ciliate move to the region of uncleaved substrate DNA step-by-step.
+<br>[[Biomod/2011/TeamJapan/Tokyo/Project#2. Track walking mode|See more]]
+</td>
+<td style="padding: 0px 10px">
+The DNA ciliates gather at a specific area where an ultraviolet (UV) light is irradiated; this is the light-irradiated gathering mode. To achieve this mode, a UV-switching DNA system based on the cis-trans isomerization of azobenzenes was designed.
+<br>[[Biomod/2011/TeamJapan/Tokyo/Project#3. Light-irradiated gathering mode|See more]]
+</td>
 </tr>
-<tr valign="top">
-<td style="padding-left: 20px">[[Biomod/2011/TeamJapan/Tokyo/Project#1. Free moving mode|The free moving mode]] is utilizing Brownian motion. We changed the size of DNA ciliate and observed the DNA ciliate movement by Brownian motion.</td>
-<td style="padding-left: 20px">[[Biomod/2011/TeamJapan/Tokyo/Project#2.The track walking mode|The track walking mode]] is utilizing deoxyribozyme activity for substrate. We checked deoxyribozyme activity and simulated DNA ciliate movement on micrometer-sized track and confirmed the track walking mode by simulation.</td>
-<td style="padding-left: 20px">[[Biomod/2011/TeamJapan/Tokyo/Project#3. Light-irradiated gathering mode|The light-irradiated gathering mode]] is utilizing UV-switching DNA. We checked the "UV-switching system" and confirmed DNA ciliate trapping at one spot.</td>
-</tr>
 </table>

Biomod/2011/TeamJapan/Tokyo: Difference between revisions

Latest revision as of 04:38, 12 March 2012

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DNA ciliate

Three independent functional modes of DNA ciliate

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