Biomod/2011/TeamJapan/Tokyo/Project/Future works: Difference between revisions

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<h1>Future works</h1>
<h1>Future works</h1>
[[image:Futureworks1.png|center|700px]]
:Our micrometer-sized DNA ciliate has a capacity for possessing many nano-devices.
:If we modify the material of the DNA ciliate body (polystyrene beads) to liposome, we can put nano-devices not only on the surface but also inside the body of the DNA ciliate.
:Trough this change, DNA ciliate will be a highly functional molecular robot where many nano-devices are cooperating. As an example of the function, DNA ciliate can carry many nanometer-sized devices at a time. We opened the door functional molecular robot.
<!--
:In our project, we designed the model of the cell size huge molecular robot called “DNA ciliate”. The model is actuated by three modes: free moving mode by Brownian motion, track walking mode by branch migration using deoxyribozyme activity, and light-irradiated mode by stopped by UV-switching-DNA’s structural change. Using these modes, we realized the switching from Brownian diffusion state to an assembly state. This system will lead the transport technology that controls micrometer-sized substance using a large numbers of nanometer-sized DNAs. It is expected not only the transport but also many interesting applications: autonomous DNA robots, new integrate method, information science and so on.
===By combing with liposome===
:One example is the micrometer-sized circulatory DNA robot, which directly implants some functional nano systems into a liposome, could had highly functions and be applied to the medical technology that continuously circulates through human blood vessels, detects and treats a focus with incorporated systems.
===Integration technology===
:Another example is the new method of integrated circuits. It's recently imperative to establish the next generation of integration technologies, because it's just a matter of time before the limit (25nm) of integrated circuits is achieved by top-down techniques. This value is made a prediction by Moore's Law. Here, we developed the way of gathering DNA cilia to an objective place. This skill could apply to the integration and break through the limitation, if we use it to assemble the structures having metal particles to arbitrary points and with optional quantities, causing some kind or another chemical reaction and building a narrow range of a circuit.
===DDS===
:The third example is a newly drug delivery system (DDS). Now, we constructed the transport system that huge micro objects are transported by many nano things. Using the mechanism, we expect that a DNA ciliate furnished extremely small drugs, which fixed on ciliate surface and had individual reactions, serves around several focuses, corresponding to drugs.
:As you can be seen, our facture has a lot of diversity. This is why our robot has two aspects. One is controlled objects, and the other is  has a certain level of autonomy. In the future, taking advantage of these characteristics, we expect that they can apply the completely chemical control and Life Sciences, medical, information science and integrated technology and so on.
-->
<!--<h1>Future works</h1>
:In this time, we fabricated the model of the cell size huge molecular robot called “DNA ciliate”. The model is actuated by Brownian motion and DNA control strands that trigger Hybridization, which includes a DNA-zyme action and a branch migration, and stopped by light irradiation that occurs to an azobenzene structural change. Using these principles, we realized the system switching from Brownian diffusion state to an assembly state. This can be also read the transport technology that controls micro-size substances using a mass of nano-size DNAs.  It is expected not only the transport but also many interesting applications; autonomous DNA robots, new integrate method, information science and so on.  
:In this time, we fabricated the model of the cell size huge molecular robot called “DNA ciliate”. The model is actuated by Brownian motion and DNA control strands that trigger Hybridization, which includes a DNA-zyme action and a branch migration, and stopped by light irradiation that occurs to an azobenzene structural change. Using these principles, we realized the system switching from Brownian diffusion state to an assembly state. This can be also read the transport technology that controls micro-size substances using a mass of nano-size DNAs.  It is expected not only the transport but also many interesting applications; autonomous DNA robots, new integrate method, information science and so on.  
===by using liposome===
===by using liposome===
Line 10: Line 27:
===DDS===
===DDS===
:The third example is a newly drug delivery system (DDS). Now, we constructed the transport system that huge micro objects are transported by many nano things. Using the mechanism, we expect that a DNA ciliate furnished extremely small drugs, which fixed in ciliate surface and had individual reactions, serves around several focuses, corresponding to drugs.
:The third example is a newly drug delivery system (DDS). Now, we constructed the transport system that huge micro objects are transported by many nano things. Using the mechanism, we expect that a DNA ciliate furnished extremely small drugs, which fixed in ciliate surface and had individual reactions, serves around several focuses, corresponding to drugs.
:As can be seen, our facture has a lot of diversity. This is why our robot has two aspects. One is a controlled objects, another is that it has a certain level of autonomy. In the future, Taking advantage of these characteristics, we expect that they could apply the completely chemical control and Life Sciences, medical, information science and integrated technology and so on.
:As can be seen, our facture has a lot of diversity. This is why our robot has two aspects. One is a controlled objects, another is that it has a certain level of autonomy. In the future, Taking advantage of these characteristics, we expect that they could apply the completely chemical control and Life Sciences, medical, information science and integrated technology and so on.-->

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<div id="navigation"> <div id="menu" style="position:static"> <ul> <li><a class="aMain" href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo">Home</a></li> <li><a class="aTeam" href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Team/Students">Team</a></li> <li><a class="aProject" href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Project">Project</a> <!-- <ul> <li><a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Project">Overview</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Project/introduction">Introduction</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Project/Model">Model</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Project/Devices">Devices</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Project/Modes">Modes</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Project/Results">Results</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Project/Achievements">Achievements</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Project/Future_works">Future works</a></li> </ul> --> <li><font color="#ffffff">Results</font> <ul> <li><a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Project/Results">Experiments</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Project/Simulations">Simulations</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Achievements/DNA_Devices">DNA Design</a></li> </ul></li> <!-- <li><a class="Simulation" href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Project/Simulations">Simulations</a></li> <li><a class="DNA design" href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Achievements/DNA_Devices">DNA Designs</a></li> --> <li><a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Project/Achievements">Achievements</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Project/Future_works">Future works</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Notebook/Protocols">Protocols</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Notebook/Lab.notebook">Notes</a></li> <li><a class="aNotebook" href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Sponsors/">Sponsors</a></li> <li><a class="aSitemap" href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Sitemap">Sitemap</a></li>

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Future works

Our micrometer-sized DNA ciliate has a capacity for possessing many nano-devices.
If we modify the material of the DNA ciliate body (polystyrene beads) to liposome, we can put nano-devices not only on the surface but also inside the body of the DNA ciliate.
Trough this change, DNA ciliate will be a highly functional molecular robot where many nano-devices are cooperating. As an example of the function, DNA ciliate can carry many nanometer-sized devices at a time. We opened the door functional molecular robot.


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