Welcome to HKBU project 2012. This year, we aim to design self-assembling iron particle for small interference RNA(siRNA) delivery, then provide cell protection to neurons. Previous work has shown that magnetic iron nanoparticles are effective carriers for gene delivery in cells. We focus specifically for the delivery of N-methyl-D-aspartate receptor 2B(NR2B) into neuronal cells. Previous studies demonstrated that the magnetic field could facilitate the particle internalization through endocytosis so as to increase the effectiveness of siRNA uptake.
In this website, we will show you our ideas , design and results.