Biomod/2012/TU Dresden/Nanosaurs/Project/References: Difference between revisions
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{{Biomod/2012/TU Dresden/Nanosaurs/Header}} | {{Biomod/2012/TU Dresden/Nanosaurs/Header}} | ||
<h2>Outlook</h2> | |||
<p>We accomplished our goal of tethering vesicles of different sizes successfully. | |||
But, we were not able to include the signal driven aptamer system due to the short | |||
duration available. Thus, we plan to use the aptamer with the closed origami | |||
structure for further experiments to prove that our system is indeed controllable. | |||
We also plan to introduce this tethering system into living cells or endosomes | |||
and observe the various impacts that this system might have on vesicle fusion, | |||
internalization etc. </p> | |||
<h3>Potential applications</h3> | |||
<h4> 1. Vesicle networks:</h4> | |||
<p>Vesicle networks with a defined connectivity and orientation can be achieved with our system. | |||
The catcher strands on the origami can be modified in several ways like having a certain | |||
complementary sequence, antibodies, biotin or any other possible modifications. Therefore, | |||
vesicles with the complementary origami system can bind to specific vesicles in determined | |||
orientations, thus establishing a highly complex and organized network. </p> | |||
<div class="img_right img_link"> | |||
<a rel="lightbox" title = “Vesicle networks” href="http://www.openwetware.org/images/9/96/BM12_nanosaurs_Network_clustering.jpg"> | |||
<img src="http://www.openwetware.org/images/2/22/BM12_nanosaurs_Network_clustering_s.jpg"> | |||
</a> | |||
</div> | |||
<h4> 2. Molecular fishing:</h4> | |||
<p>The inherent capability of the tethering system can be used to ‘fish’ certain target species from the blood or other solutions. The catcher strands can have antibodies specific to an antigen or any multi-component affinity system. For example, this system can be used to fish out any harmful peptide toxins using specific antibodies coupled to the catcher strands. It can also be used in ex-vivo applications. </p> | |||
<div class="img_left img_link"> | |||
<a rel="lightbox" title = “Molecular fishing” href="http://www.openwetware.org/images/2/27/BM12_nanosaurs_Origami_fishing_v2.jpg"> | |||
<img src="http://www.openwetware.org/images/0/02/BM12_nanosaurs_Origami_fishing_v2_s.jpg"> | |||
</a> | |||
</div> | |||
Revision as of 20:15, 27 October 2012
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Outlook
We accomplished our goal of tethering vesicles of different sizes successfully. But, we were not able to include the signal driven aptamer system due to the short duration available. Thus, we plan to use the aptamer with the closed origami structure for further experiments to prove that our system is indeed controllable. We also plan to introduce this tethering system into living cells or endosomes and observe the various impacts that this system might have on vesicle fusion, internalization etc.
Potential applications
1. Vesicle networks:
Vesicle networks with a defined connectivity and orientation can be achieved with our system. The catcher strands on the origami can be modified in several ways like having a certain complementary sequence, antibodies, biotin or any other possible modifications. Therefore, vesicles with the complementary origami system can bind to specific vesicles in determined orientations, thus establishing a highly complex and organized network.
<a rel="lightbox" title = “Vesicle networks” href="http://www.openwetware.org/images/9/96/BM12_nanosaurs_Network_clustering.jpg"> <img src="http://www.openwetware.org/images/2/22/BM12_nanosaurs_Network_clustering_s.jpg"> </a>
2. Molecular fishing:
The inherent capability of the tethering system can be used to ‘fish’ certain target species from the blood or other solutions. The catcher strands can have antibodies specific to an antigen or any multi-component affinity system. For example, this system can be used to fish out any harmful peptide toxins using specific antibodies coupled to the catcher strands. It can also be used in ex-vivo applications.
<a rel="lightbox" title = “Molecular fishing” href="http://www.openwetware.org/images/2/27/BM12_nanosaurs_Origami_fishing_v2.jpg"> <img src="http://www.openwetware.org/images/0/02/BM12_nanosaurs_Origami_fishing_v2_s.jpg"> </a>
