Biomod/2012/TeamSendai/Idea: Difference between revisions

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<h1>Gate</h1>
<h1>Gate</h1>
<p>
<p>
<img src="http://openwetware.org/images/9/94/Gate.png " alt="hybrid graph" align="left" width="300px" height="200px" >
We will make the gate made of DNA origami! DNA origami is the way how to fold DNA and make structure investigated by Paul Rothemund. So we decided to make the tube structure  
We will make the gate made of DNA origami! DNA origami is the way how to fold DNA and make structure investigated by Paul Rothemund. So we decided to make the tube structure  
as the Gate using DNA origami. Consideration for the form of the Gate is written on Design page "Gate".(ここにデザインページGATEへのリンクを!..)
as the Gate using DNA origami. Consideration for the form of the Gate is written on Design page "Gate".(ここにデザインページGATEへのリンクを!..)
In the Gate, "Porter" which transport the target is planted. So Gate can connect the inside and outside. We can use the Gate as an injector or extractor.
In the Gate, "Porter" which transport the target is planted. So Gate can connect the inside and outside. We can use the Gate as an injector or extractor.
The simulation that the targets actually enter in the Gate is here.(simlationへのリンクを！..)
The simulation that the targets actually enter in the Gate is here.(simlationへのリンクを！..)
<img src="http://openwetware.org/images/9/94/Gate.png " alt="hybrid graph" align="left" width="300px" height="200px" >
 
</br>
</br>
</br>
</br>

Revision as of 01:27, 26 October 2012

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<body> <div id="Container"> <!-- Menu --> <ul id="menu"> <li><a href="http://openwetware.org/wiki/Biomod/2012/Tohoku/Team_Sendai ">Home</a></li> <li><a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Idea ">Project</a></li> <li><a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Design">Design</a> </li> <li><a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Simulation">Simulation</a> </li> <li> <a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Experiment ">Experiment</a> </li> <li> <a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Future Application">Future Application</a> </li> <li> <a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Diary">Diary</a> </li> <li> <a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Team ">Team</a> </li> <li> <a href=" http://openwetware.org/wiki/Biomod/2012/Tohoku/Team Sendai/header"></a> </li>

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<h1>Project</h1> <img src=" http://openwetware.org/images/c/c8/Format_cell_gate.jpg " alt="hybrid graph" align="left" width="465px" height="315px" > <p> We want to make an artificial channel. If we make an artificial channel, it is desirable that the channel can carry selectively and actively only what we want to carry. Also, it is desirable that the channel can change its function and shape artificially. Think of these things, we think it is best to make this structure with DNA-origami. If we use DNA, the shape of the channel is changeable as we like. Also, the carry structure that through the channel is possible by using DNA’s complementarity, so we decided to use DNA to make the structure. When we test the effect of the artificial channel, we use liposome as a model of a cell membrane. In short, our goal in this experiment is THIS! (画像) Our experiment separates three parts; channel structure part, carry system part, and liposome part.(画像) </br> </br> </br> </br> </br> </br> </br> </br> </br> </br> </p>

<h1>Gate</h1> <p> <img src="http://openwetware.org/images/9/94/Gate.png " alt="hybrid graph" align="left" width="300px" height="200px" > We will make the gate made of DNA origami! DNA origami is the way how to fold DNA and make structure investigated by Paul Rothemund. So we decided to make the tube structure as the Gate using DNA origami. Consideration for the form of the Gate is written on Design page "Gate".(ここにデザインページGATEへのリンクを!..) In the Gate, "Porter" which transport the target is planted. So Gate can connect the inside and outside. We can use the Gate as an injector or extractor. The simulation that the targets actually enter in the Gate is here.(simlationへのリンクを！..)

</br> </br> </br> </br> </br> </br> </br> </br> </br> </br> </br> </br> </p>

<h1>Porter</h1> <p> If we design that the DNA binds the target more stable than former one, and if next DNA binds more stable than it…, the target moves to most complementary sequence DNA. We thought this characteristic of DNA can be utilized the power of channel. This channel can make us transport the object selectively and actively independent of concentration gradient. We make porter made of single stranded DNA! <img src="http://openwetware.org/images/e/eb/Porterget.png " alt="hybrid graph" align="left" width="465px" height="315px" >

<br clear="left"> </p>

<h1>Membrane</h1> <p> We make liposome by using lipid, and utilize liposome as model of cell-membrane. reference from "the CELL" </p> <img src="http://openwetware.org/images/4/4b/Membranerane.png " alt="hybrid graph" align="left" width="300px" height="350px" >

<br clear="left"> </p>

<h1>Application in future</h1> <p> Finally, this project aims to attach to real cell and transport a substance to cell and from cell. Of cause, this channel can be applied to medical use. Also, it can

be used for bring some substance which it is difficult to bring back now from cell. In this experiment, we used liposome as a model of a cell membrane, but if we consider the channel attached liposome as one robot, the robot can use to cleaner robot or medical sprinkling robot. </p> </div>

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