Biomod/2012/Tohoku/Team Sendai

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<text-align="center"><h1>We want to create a new channel made of DNA!!</h1>
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<p>
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<h1 style="width:900px;clear:left;margin:15px;">
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We want to create a channel that does not exist in nature. DNA is a designable molecule and has interaction with various biomolecules. Thus, a channel made of DNA enables to transport more various biomolecules against energy gradient.
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Abstract</h1>
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Such a new channel will be used…</br>
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<p style="width:900px;clear:left;margin:15px;">
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1. In medical care, because it can transport new molecules that are unable to be transported into cells without DNA.</br>
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&nbsp;All the creatures on Earth are made of cells. The exterior and the interior of the cell are compartmentalized by biomembranes.
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2. For sampling what we want from cells.</br>
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A nanodevice that is able to actively transport only the specific oligonucleotide through the biomembrane has a great potential to deliver siRNA into the cell or to extract mRNA expressed in the cell.<br>
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3. For BIOROOMBA by compositing with artificial liposome.( Off course use for DDS)
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Here, we decided to create a novel device with such a function. <br>
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(図を考える)</br>
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We have designed a cylindrical injector/extractor device made of DNA origami. Inside the cylinder, a cascade of single stranded DNAs is planted. Once the outer-most ssDNA binds to a target oligonucleotide, the target is passed to the inner-ones one by one because of the higher bonding energy assigned to the inner ones.<br>
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We also investigate how the cylinder penetrates the biomembrane by using liposome as a model membrane.<br>
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<br>
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<h2><!--Abstract-->Project Image</h2>
<h2><!--Abstract-->Project Image</h2>
<img src="http://openwetware.org/images/c/c5/Projectcellgate.png" alt="D-Heart" width="400px"><br>
<img src="http://openwetware.org/images/c/c5/Projectcellgate.png" alt="D-Heart" width="400px"><br>
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<strong>Porter</strong>: Single stranded DNA. Once the outer-most ssDNA binds to a target, the target is passed to the inner-ones one by one.</br>
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<strong>Gate</strong>: Cylindrical structure connecting the inside and outside like gates. A cascade of the "Selector" is planted in this. We can use this as an injector or extractor.</br>
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<strong>Membrane</strong>: The exterior and the interior of the cell are compartmentalized by biomembranes. We use liposome as a model membrane.
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</p>
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<h1 style="width:900px;clear:left;margin:15px;">
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Abstract</h1>
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<p style="width:900px;clear:left;margin:15px;">
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&nbsp;All the creatures on Earth are made of cells. The exterior and the interior of the cell are compartmentalized by biomembranes.
+
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A nanodevice that is able to actively transport only the specific oligonucleotide through the biomembrane has a great potential to deliver siRNA into the cell or to extract mRNA expressed in the cell.<br>
+
-
Here, we decided to create a novel device with such a function. <br>
+
-
We have designed a cylindrical injector/extractor device made of DNA origami. Inside the cylinder, a cascade of single stranded DNAs is planted. Once the outer-most ssDNA binds to a target oligonucleotide, the target is passed to the inner-ones one by one because of the higher bonding energy assigned to the inner ones.<br>
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We also investigate how the cylinder penetrates the biomembrane by using liposome as a model membrane.<br>
+
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<br>
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<strong>Porter</strong>: Single stranded DNA. Once the outer-most ssDNA binds to a target, the target is passed to the inner-ones one by one.</br>
+
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<strong>Gate</strong>: Cylindrical structure connecting the inside and outside like gates. A cascade of the "Selector" is planted in this. We can use this as an injector or extractor.</br>
+
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<strong>Membrane</strong>: The exterior and the interior of the cell are compartmentalized by biomembranes. We use liposome as a model membrane.</br>
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</p>
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<a href=" http://openwetware.org/wiki/Biomod/2012/Team_Sendai_Old">Test page</a>
<a href=" http://openwetware.org/wiki/Biomod/2012/Team_Sendai_Old">Test page</a>

Revision as of 23:03, 26 October 2012

Team Sendai Top


ロゴはもうちょっと考えるべきかも

Abstract

 All the creatures on Earth are made of cells. The exterior and the interior of the cell are compartmentalized by biomembranes. A nanodevice that is able to actively transport only the specific oligonucleotide through the biomembrane has a great potential to deliver siRNA into the cell or to extract mRNA expressed in the cell.
Here, we decided to create a novel device with such a function.
We have designed a cylindrical injector/extractor device made of DNA origami. Inside the cylinder, a cascade of single stranded DNAs is planted. Once the outer-most ssDNA binds to a target oligonucleotide, the target is passed to the inner-ones one by one because of the higher bonding energy assigned to the inner ones.
We also investigate how the cylinder penetrates the biomembrane by using liposome as a model membrane.

Project Image

D-Heart
Porter: Single stranded DNA. Once the outer-most ssDNA binds to a target, the target is passed to the inner-ones one by one.
Gate: Cylindrical structure connecting the inside and outside like gates. A cascade of the "Selector" is planted in this. We can use this as an injector or extractor.
Membrane: The exterior and the interior of the cell are compartmentalized by biomembranes. We use liposome as a model membrane.

Movie



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