Biomod/2012/UCSD/tRiton Nano Architects/Project introduction

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=Motivation=
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=Concepts=
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Why did we do this project?
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==What is an Aptamer?==
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===Summer Goals===
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An aptamer is a stable DNA or RNA molecule that has been selected from random pools based on it’s ability to bind with high affinity to target molecules such as small organics, proteins, and even entire cells. Unlike antibodies, aptamers are selected in vitro, are capable of higher specificity and affinity, can tolerate pH and temperatures that their protein counterparts cannot. These features allow them to be highly specific detectors and to be stored at ambient temperatures with much higher shelf life.
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What was our goals in this project for the summer?
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==References==
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=Future Expectations=
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1. Stoltenburg R, Reinemann C, Strehlitz B: SELEX–a (r)evolutionary method to generate high-affinity nucleic acid ligands. Biomolecular engineering 2007, 24:381-403.
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2. Jayasena SD: Aptamers: An Emerging Class of Molecules That Rival Antibodies in Diagnostics. Clinical Chemistry 1999, 45:1628-1650.
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Coming Soon
 

Revision as of 02:04, 28 October 2012

Concepts

What is an Aptamer?

An aptamer is a stable DNA or RNA molecule that has been selected from random pools based on it’s ability to bind with high affinity to target molecules such as small organics, proteins, and even entire cells. Unlike antibodies, aptamers are selected in vitro, are capable of higher specificity and affinity, can tolerate pH and temperatures that their protein counterparts cannot. These features allow them to be highly specific detectors and to be stored at ambient temperatures with much higher shelf life.

References

1. Stoltenburg R, Reinemann C, Strehlitz B: SELEX–a (r)evolutionary method to generate high-affinity nucleic acid ligands. Biomolecular engineering 2007, 24:381-403.

2. Jayasena SD: Aptamers: An Emerging Class of Molecules That Rival Antibodies in Diagnostics. Clinical Chemistry 1999, 45:1628-1650.


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