Biomod/2012/UTokyo/UT-Hongo

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<p><a href="http://openwetware.org/wiki/Biomod/2012/UTokyo/UT-Hongo/Function"><img src="http://openwetware.org/images/a/a0/Biomod-2012-UTokyo-UT-Hongo-outline-2.jpg" class="mythumb" alt="" /></a></p>
<p><a href="http://openwetware.org/wiki/Biomod/2012/UTokyo/UT-Hongo/Function"><img src="http://openwetware.org/images/a/a0/Biomod-2012-UTokyo-UT-Hongo-outline-2.jpg" class="mythumb" alt="" /></a></p>
<h2>Design</h2>
<h2>Design</h2>
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<p>In this section, we describe how we designed our DNA shell which can efficiently capture the target molecules and be observed with dramatic change in the fluorescence when it closes. Furthermore, we show the simulation for hybridization of DNA shell.</p>
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Revision as of 23:29, 23 October 2012

The University of Tokyo


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fig1. Schematic of Medical DNA Shell system

Methodologies to apply DNA for building precisely controlled nanostructures have greatly developed over the recent years. Our focus for BIOMOD is to utilize DNA to make a shell like structure which can capture molecules inside the shell-like body, as if a shellfish is eating its prey. Entrapment of the substrate was detected by the numerous florescent molecules that are attached to the body. This research may become a foundation for using DNA to mimic catalytic activity of enzymes.


fig2.

Medical functions such as detection of diseases with small amount of blood are possible by using microfluidics. For example, detecting and sensing the concentration of Thrombin which causes blood coagulation is possible by using Shell and microfluidics developed by our team. In the future, we will develop medical DNA Shell system for monitoring components of blood, detecting diseases, inputting medicine by DNA Shell, computing system integrated in microfluidics.


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