Biomod/2012/UTokyo/UT-Hongo

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<p><a href="http://openwetware.org/wiki/Biomod/2012/UTokyo/UT-Hongo/Intro"><img src="http://openwetware.org/images/d/d7/Biomod-2012-UTokyo-UT-Hongo_Design_Thumb.jpeg" class="mythumb" alt="" /></a></p>
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<p><a href="http://openwetware.org/wiki/Biomod/2012/UTokyo/UT-Hongo/Intro"><img src="http://openwetware.org/images/d/d7/Biomod-2012-UTokyo-UT-Hongo_Design_Thumb_2.jpeg" class="mythumb" alt="" /></a></p>
<h2>Motives</h2>
<h2>Motives</h2>
<p>The great scope of our research is to make a DNA origami structure that has functionalities similar to that of enzymes... however, that is far too much for students to do in one summer. Therefore, we chose to narrow down to making a structure which can bind to certain molecules and capture it, just like enzymes makes specific bondings to make ES complex.</p>
<p>The great scope of our research is to make a DNA origami structure that has functionalities similar to that of enzymes... however, that is far too much for students to do in one summer. Therefore, we chose to narrow down to making a structure which can bind to certain molecules and capture it, just like enzymes makes specific bondings to make ES complex.</p>

Revision as of 01:42, 28 October 2012

The University of Tokyo


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Fig1. Schematic animation of DNA Shell

Our focus for BIOMOD is to utilize DNA to make a shell like structure which can capture molecules inside the body, as if a shellfish is capturing its prey. The device, named DNA Shell, can exhibit functionalities such as highly sensitive detection, enzyme protection, and attachment to solid surfaces. All these new functionalities are the result of this new capturing mechanism that we call the "Shell Mechanism" and the feasibility of modifications on the DNA structure. The functionalities of the DNA shell, along with the enzyme that is captured, may allow us to open up fields of applications in chemical and medical applications, such as in bioreactors and in biomolecule detection.


Fig2. Schematic animation of the DNA Shell system

The DNA shell is made of three domains of DNA origamis. The two domains would be used to capture enzymes, and the last domain would be used to attach to a solid surface as is shown in Fig.2. Our experiments were done using a certain protein called Streptavidin. To widen the types of enzymes that could be captured in the DNA Shell, there needs to be more work to be done to find different aptamers that bind specifically to certain enzymes. However, with such developments, we hope and strongly believe that this nano-device would give innovative boost to the enzyme application.


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