Biomod/2012/UTokyo/UT-Hongo

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     <a href="http://www.u-tokyo.ac.jp/en/" target="_blank"><img src="http://www.u-tokyo.ac.jp/en/images/banner/UT-logo.gif" width="234" height="60" border="0" alt="The University of Tokyo"></img></a>
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<li class="toppage"><a href="/wiki/Biomod/2012/UTokyo/UT-Hongo">Top</a></li> <li class="motives"><a href="/wiki/Biomod/2012/UTokyo/UT-Hongo/Intro">Motives</a></li> <!-- <li class="design"><a href="/wiki/Biomod/2012/UTokyo/UT-Hongo/Function">Design</a></li> --> <li class="result"><a href="/wiki/Biomod/2012/UTokyo/UT-Hongo/Assembly">Design & Results</a> <ul class="submenu"> <li><a href="/wiki/Biomod/2012/UTokyo/UT-Hongo/Assembly#Assembly_of_the_DNA_Shell">Assembly of the DNA Shell</a></li> <li><a href="/wiki/Biomod/2012/UTokyo/UT-Hongo/Assembly#Capturing_ability">Capturing Ability</a></li> <li><a href="/wiki/Biomod/2012/UTokyo/UT-Hongo/Assembly#Immobilizing_on_microfluidic_device">Immobilizing on microfluidic device</a></li> <li><a href="/wiki/Biomod/2012/UTokyo/UT-Hongo/Assembly#Supporting_Enzyme">Supporting Enzyme</a></li> </ul> </li> <li class="method"><a href="/wiki/Biomod/2012/UTokyo/UT-Hongo/Method">Method</a></li> <li class="futurework"><a href="/wiki/Biomod/2012/UTokyo/UT-Hongo/FutureWork">Progress & Beyond</a></li> <li class="team"><a href="/wiki/Biomod/2012/UTokyo/UT-Hongo/Team">Team</a></li> <li class="acknowledgement"><a href="/wiki/Biomod/2012/UTokyo/UT-Hongo/Acknowledgement">Acknowledgement</a></li> 

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Abstract

Methodologies to apply DNA for building precisely controlled nanostructures have greatly developed over the recent years. Our focus for BIOMOD is to utilize DNA to make a shell like structure which can capture molecules inside the shell-like body, as if a shellfish were eating its prey. Entrapment of the substrate was detected by the numerous florescent molecules that are attached to the body. This research may become a foundation for using DNA to mimmick catalytic activity of enzymes.

Wiki ToDo

THIS SECTION IS TEMPORALLY AND WILL BE REMOVED LATER --Yuichi Nishiwaki 02:01, 22 August 2012 (EDT)

  • Page1.Title


内容はアブストラクトの使いまわし。ほかのページへのリンクがすべてまとまっているといい。
  • Page 2. Introduction

Methodologies to apply DNA for building precisely controlled nanostructures have greatly developed over the recent years. Our focus for BIOMOD is to utilize DNA to make a shell like structure which can capture molecules inside the shell-like body, as if a shellfish is eating its prey. Entrapment of the substrate was detected by the numerous florescent molecules that are attached to the body. This research may become a foundation for using DNA to mimic catalytic activity of enzymes.Medical functions such as detection of diseases with small amount of blood are possible by using microfluidics. For example, detecting and sensing the concentration of Thrombin which causes blood coagulation is possible by using Shell and microfluidics developed by our team. In the future, we will develop medical DNA Shell system for monitoring components of blood, detecting diseases, inputting medicine by DNA Shell, computing system integrated in microfluidics.

画像を挿入 Fig. 1 Schematic of Medical DNA Shell system

Microfluidic device Microfluidic technologies provide numbers of advantageous features especially for biological applications. Researchers have been working on PDMS (polydimethylsiloxane)-based microfluidic devices for microscale biochemical operations. It pours liquid to microscopic channels and operates the biochemical reaction, separation. In micro space, the ratio of the surface area to the volume of fluid is remarkably large compared with the usual scale. Therefore, walls and fluid interface exert a large influence on reaction and migration phenomenon. So we can analyze target molecule by micro amount of samples using microfluidic. Also it can form laminar flow. Then we use the device (Fig. 2) in order that only a part of fixed shell reacts to quenching matter. The reason of fixing Shell is that a shift of fluorescence intensity becomes intelligible by observing the time variation of a specific portion.


Y字の画像(Fig.2)


どういう工程で作業を進めたのかを示す。
  • Page2. Blueprint
和家くんのCADNANOの写真
  • Page３．Assembly
オリガミの組み立て、電気泳動の写真、AFM
  • Page4.　機能化
  • Page5.　今後の研究
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