Biomod/2013/Aarhus/Supplementary/Supplementary Data: Difference between revisions

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[[image:origami 3.png|center|frame|Table S1. Details of the different modules of the plate.]]
[[image:origami 3.png|center|frame|Table S1. Details of the different modules of the plate.]]
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[[image:origami 7.png|center|frame|Table S2. Details of the dome structure.]]


[[image:origami 8.png|center|frame|Table S3.Details of the different modules.]]
[[Biomod/2013/Aarhus/Supplementary/Supplementary_Informations#Staple_strands_for_the_plate|Staple strand sequences for the plate]] see supplementary information.


===sisiRNA===


====Yields of RP-HPLC purifications of the modified strands====


[[image:table sisi 1.png|center|frame|Table S4: Yields of RP-HPLC purifications of the 12 modified strands.]]
[[image:origami 7.png|center|frame|Table S2. Details of the dome structure.]]
 
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====Estimated yields of the annealing reactions====
[[image:origami 8.png|center|frame|Table S3.Details of the different dome modules.]]
[[image:table sisi 2.png|center|frame|Table S5. Estimated yields of the annealing reactions.]]
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====Luciferase knockdown with all singly modified duplexes====
[[Biomod/2013/Aarhus/Supplementary/Supplementary_Informations#Staple_strands_for_the_dome|Figure and staple strand sequences for the dome]] see supplementary information.
[[image:sisi sup 3.png|950px|Fig. S1. Cell viability corrected luciferase activities for all singly modified duplexes, transfected with Lipofectamine. Click on the image and choose 'high resolution' for details.]]


[[image:sisi supp 4.png|center|frame|Table S6. Best fit IC50 values of all knockdown experiments using singly modified duplexes using Lipofectamine.The IC50 value for W179-PEG1K was calculated with a low R2 value and is not conclusive.]]


[[image:sisi supp 5.png|950px|Fig. S2. Luciferase and MTT measurements of all knockdown experiments with singly modified duplexes using Lipofectamine.]]


===System in action===
====Radioactive labeling of W376====


[[image:sys sisi 1.png|center|frame|Fig. S3. 1) 25 bp DNA ladder, 2) 6 µL labeled W376, 3) 1 pmol W376, 4) 1.5 pmol W376, 5) pmol W376, 6) 2.5 pmol W376,  7) pmol W376.]]
The band containing the labeled sample appears most similar to that in lane 4 which means that the 6 µL that were run on the gel contained  1.5 pmol W376, corresponding to a concentration of 0.25 µM in the purified sample.


===Cholesterol===
===Cholesterol===


'''<sup>1</sup>H NMR, <sup>13</sup>C NMR and IR of compound 4.'''  
'''<sup>1</sup>H NMR, <sup>13</sup>C NMR and IR of compound 4.'''  


<html><A name="NMR4H"/></html> [[Image:Biomod_Aarhus_Chem_NMR_4H.png|900x900px|Center|thumb|<sup>1</sup>H NMR for compound 4]]
<html><A name="NMR4H"/></html>  
<html><A name="NMR4C"/></html>[[Image:Biomod_Aarhus_Chem_NMR_4C1.png|900x900px|Center|thumb|<sup>13</sup>C NMR for compound 4]]
[[Image:Biomod_Aarhus_Chem_NMR_4H.png|900x900px|Center|thumb|<sup>1</sup>H NMR 0f compound 4]]
[[Image:Biomod_Aarhus_Chem_NMR_4C2.png|900x900px|Center|thumb|Zoom of <sup>13</sup>C NMR for compound 4]]
<html><br style="clear:both;"/></html>
<html><A name="IR4"/></html>[[Image:Biomod_Aarhus_Chem_IR4.png|900x900px|Center|thumb|IR for compound 4]]
<html><A name="NMR4C"/></html>  
 
[[Image:Biomod_Aarhus_Chem_NMR_4C1.png|900x900px|Center|thumb|<sup>13</sup>C NMR of compound 4]]
<html><br style="clear:both;"/></html>
[[Image:Biomod_Aarhus_Chem_NMR_4C2.png|900x900px|Center|thumb|Zoom of <sup>13</sup>C NMR of compound 4]]
<html><br style="clear:both;"/></html>
<html><A name="IR4"/></html>  
[[Image:Biomod_Aarhus_Chem_IR4.png|900x900px|Center|thumb|IR of compound 4]]
<html><br style="clear:both;"/></html>
'''<sup>1</sup>H NMR, <sup>13</sup>C NMR and IR of compound 5.'''
'''<sup>1</sup>H NMR, <sup>13</sup>C NMR and IR of compound 5.'''


<html><A name="NMR5H"/></html>[[Image:Biomod_Aarhus_Chem_NMR_5H.png|900x900px|Center|thumb|<sup>1</sup>H NMR for compound 5]]
<html><A name="NMR5H"/></html>  
<html><A name="NMR5C"/></html>[[Image:Biomod_Aarhus_Chem_NMR_5C1.png|900x900px|Center|thumb|<sup>13</sup>C NMR for compound 5]]
[[Image:Biomod_Aarhus_Chem_NMR_5H.png|900x900px|Center|thumb|<sup>1</sup>H NMR of compound 5]]
[[Image:Biomod_Aarhus_Chem_NMR_5C2.png|900x900px|Center|thumb|Zoom of <sup>13</sup>C NMR for compound 5]]
<html><br style="clear:both;"/></html>
<html><A name="IR5"/></html>[[Image:Biomod_Aarhus_Chem_IR5.png|900x900px|Center|thumb|IR for compound 5]]
<html><A name="NMR5C"/></html>  
 
[[Image:Biomod_Aarhus_Chem_NMR_5C1.png|900x900px|Center|thumb|<sup>13</sup>C NMR of compound 5]]
<html><br style="clear:both;"/></html>
[[Image:Biomod_Aarhus_Chem_NMR_5C2.png|900x900px|Center|thumb|Zoom of <sup>13</sup>C NMR of compound 5]]
<html><br style="clear:both;"/></html>
<html><A name="IR5"/></html>  
[[Image:Biomod_Aarhus_Chem_IR5.png|900x900px|Center|thumb|IR of compound 5]]
<html><br style="clear:both;"/></html>
'''<sup>1</sup>H NMR and <sup>13</sup>C NMR of compound 6.'''
'''<sup>1</sup>H NMR and <sup>13</sup>C NMR of compound 6.'''


<html><A name="NMR6H"/></html>[[Image:Biomod_Aarhus_Chem_NMR_6H.png|900x900px|Center|thumb|<sup>1</sup>H NMR for compound 6]]
<html><A name="NMR6H"/></html>  
<html><A name="NMR6C"/></html>[[Image:Biomod_Aarhus_Chem_NMR_6C.png|900x900px|Center|thumb|<sup>13</sup>C NMR for compound 6]]
[[Image:Biomod_Aarhus_Chem_NMR_6H.png|900x900px|Center|thumb|<sup>1</sup>H NMR of compound 6]]
[[Image:Biomod_Aarhus_Chem_NMR_6C2.png|900x900px|Center|thumb|Zoom of <sup>13</sup>C NMR for compound 6]]
<html><br style="clear:both;"/></html>
 
<html><A name="NMR6C"/></html>  
[[Image:Biomod_Aarhus_Chem_NMR_6C.png|900x900px|Center|thumb|<sup>13</sup>C NMR of compound 6]]
<html><br style="clear:both;"/></html>
[[Image:Biomod_Aarhus_Chem_NMR_6C2.png|900x900px|Center|thumb|Zoom of <sup>13</sup>C NMR of compound 6]]
<html><br style="clear:both;"/></html>
===Photosensitizer===
===Photosensitizer===
'''<sup>1</sup>H NMR and <sup>13</sup>C NMR of compound 7.'''
'''<sup>1</sup>H NMR and <sup>13</sup>C NMR of compound 7.'''


[[Image:Biomod_Aarhus_Chem_NMR_7H.png|900x900px|Center|thumb|<sup>1</sup>H NMR for compound '''7''']]
<html><A name="NMR7H"/></html> [[Image:Biomod_Aarhus_Chem_NMR_7H.png|900x900px|Center|thumb|<sup>1</sup>H NMR of compound '''7''']]
[[Image:Biomod_Aarhus_Chem_NMR_7C.png|900x900px|Center|thumb|<sup>13</sup>C NMR for compound '''7''']]
<html><br style="clear:both;"/></html>
<html><A name="NMR7C"/></html> [[Image:Biomod_Aarhus_Chem_NMR_7C.png|900x900px|Center|thumb|<sup>13</sup>C NMR of compound '''7''']]
<html><br style="clear:both;"/></html>


'''<sup>1</sup>H NMR and <sup>13</sup>C NMR of compound 8.'''
'''<sup>1</sup>H NMR and <sup>13</sup>C NMR of compound 8.'''


[[Image:Biomod_Aarhus_Chem_NMR_8H.png|900x900px|Center|thumb|<sup>1</sup>H NMR for compound '''8''']]
<html><A name="NMR8H"/></html> [[Image:Biomod_Aarhus_Chem_NMR_8H.png|900x900px|Center|thumb|<sup>1</sup>H NMR of compound '''8''']]
[[Image:Biomod_Aarhus_Chem_NMR_8C.png|900x900px|Center|thumb|<sup>13</sup>C NMR for compound '''8''']]
<html><br style="clear:both;"/></html>
<html><A name="NMR8C"/></html> [[Image:Biomod_Aarhus_Chem_NMR_8C.png|900x900px|Center|thumb|<sup>13</sup>C NMR of compound '''8''']]
<html><br style="clear:both;"/></html>


'''<sup>1</sup>H NMR, <sup>13</sup>C NMR and UV of compound 9.'''
'''<sup>1</sup>H NMR, <sup>13</sup>C NMR and UV of compound 9.'''


[[Image:Biomod_Aarhus_Chem_NMR_9H.png|900x900px|Center|thumb|<sup>1</sup>H NMR for compound '''9''']]
<html><A name="NMR9H"/></html> [[Image:Biomod_Aarhus_Chem_NMR_9H.png|900x900px|Center|thumb|<sup>1</sup>H NMR of compound '''9''']]
[[Image:Biomod_Aarhus_Chem_NMR_9C.png|900x900px|Center|thumb|<sup>13</sup>C NMR for compound '''9''']]
<html><br style="clear:both;"/></html>
[[Image:Biomod_Aarhus_Chem_10UV.png|900x900px|Center|UV for compound '''9''']]
<html><A name="NMR9C"/></html> [[Image:Biomod_Aarhus_Chem_NMR_9C.png|900x900px|Center|thumb|<sup>13</sup>C NMR of compound '''9''']]
<html><br style="clear:both;"/></html>
<html><A name="9UV"/></html> [[Image:Biomod_Aarhus_Chem_10UV.png|900x900px|Center|UV of compound '''9''']]
<html><br style="clear:both;"/></html>




'''<sup>1</sup>H NMR, <sup>13</sup>C NMR and UV of compound 10.'''
'''<sup>1</sup>H NMR, <sup>13</sup>C NMR and UV of compound 10.'''


[[Image:Biomod_Aarhus_Chem_NMR_10H.png|900x900px|Center|thumb|<sup>1</sup>H NMR for compound '''10''']]
<html><A name="NMR10H"/></html> [[Image:Biomod_Aarhus_Chem_NMR_10H.png|900x900px|Center|thumb|<sup>1</sup>H NMR of compound '''10''']]
[[Image:Biomod_Aarhus_Chem_NMR_10C.png|900x900px|Center|thumb|<sup>13</sup>C NMR for compound '''10''']]
<html><br style="clear:both;"/></html>
[[Image:Biomod_Aarhus_Chem_11UV.png|900x900px|Center|UV for compound '''10''']]
<html><A name="NMR10C"/></html> [[Image:Biomod_Aarhus_Chem_NMR_10C.png|900x900px|Center|thumb|<sup>13</sup>C NMR of compound '''10''']]
 
<html><br style="clear:both;"/></html>
<html><A name="10UV"/></html> [[Image:Biomod_Aarhus_Chem_11UV.png|900x900px|Center|UV of compound '''10''']]
<html><br style="clear:both;"/></html>


'''<sup>1</sup>H NMR and <sup>13</sup>C NMR of compound 11.'''
'''<sup>1</sup>H NMR and <sup>13</sup>C NMR of compound 11.'''


[[Image:Biomod_Aarhus_Chem_NMR_11H.png|900x900px|Center|thumb|<sup>1</sup>H NMR for compound '''11''']]
<html><A name="NMR11H"/></html> [[Image:Biomod_Aarhus_Chem_NMR_11H.png|900x900px|Center|thumb|<sup>1</sup>H NMR of compound '''11''']]
[[Image:Biomod_Aarhus_Chem_NMR_11C.png|900x900px|Center|thumb|<sup>13</sup>C NMR for compound '''11''']]
<html><br style="clear:both;"/></html>
 
<html><A name="NMR11C"/></html> [[Image:Biomod_Aarhus_Chem_NMR_11C.png|900x900px|Center|thumb|<sup>13</sup>C NMR of compound '''11''']]
<html><br style="clear:both;"/></html>


'''<sup>1</sup>H NMR and <sup>13</sup>C NMR of compound 12.'''
'''<sup>1</sup>H NMR and <sup>13</sup>C NMR of compound 12.'''


[[Image:Biomod_Aarhus_Chem_NMR_12H.png|900x900px|Center|thumb|<sup>1</sup>H NMR for compound '''12''']]
<html><A name="NMR12H"/></html> [[Image:Biomod_Aarhus_Chem_NMR_12H.png|900x900px|Center|thumb|<sup>1</sup>H NMR of compound '''12''']]
[[Image:Biomod_Aarhus_Chem_NMR_12C.png|900x900px|Center|thumb|<sup>13</sup>C NMR for compound '''12''']]
<html><br style="clear:both;"/></html>
<html><A name="NMR12C"/></html> [[Image:Biomod_Aarhus_Chem_NMR_12C.png|900x900px|Center|thumb|<sup>13</sup>C NMR of compound '''12''']]
<html><br style="clear:both;"/></html>


===5-propargylamino-ddUTP===
===5-propargylamino-ddUTP===
'''<sup>1</sup>H NMR, <sup>13</sup>C NMR and IR for compound 15.'''


[[Image:Biomod_Aarhus_Chem_NMR_15H.png|900x900px|Center|thumb|<sup>1</sup>H NMR for compound 15]]
'''<sup>1</sup>H NMR, <sup>13</sup>C NMR and IR of compound 15.'''
[[Image:Biomod_Aarhus_Chem_NMR_15H2.png|900x900px|Center|thumb|zoom of <sup>1</sup>H NMR for compound 15]]
[[Image:Biomod_Aarhus_Chem_NMR_15C.png|900x900px|Center|thumb|<sup>13</sup>C NMR for compound 15]]
[[Image:Biomod_Aarhus_Chem_IR15.png|900x900px|Center|thumb|IR for compound 15]]


'''<sup>1</sup>H NMR, <sup>13</sup>C NMR and IR for compound 16.'''
<html><A name="NMR15H"/></html>[[Image:Biomod_Aarhus_Chem_NMR_15H.png|900x900px|Center|thumb|<sup>1</sup>H NMR of compound 15]]
<html><br style="clear:both;"/></html>
[[Image:Biomod_Aarhus_Chem_NMR_15H2.png|900x900px|Center|thumb|zoom of <sup>1</sup>H NMR of compound 15]]
<html><br style="clear:both;"/></html>
<html><A name="NMR15C"/></html>[[Image:Biomod_Aarhus_Chem_NMR_15C.png|900x900px|Center|thumb|<sup>13</sup>C NMR of compound 15]]
<html><br style="clear:both;"/></html>
<html><A name="IR15"/></html>[[Image:Biomod_Aarhus_Chem_IR15.png|900x900px|Center|thumb|IR of compound 15]]
<html><br style="clear:both;"/></html>


[[Image:Biomod_Aarhus_Chem_NMR_16H.png|900x900px|Center|thumb|<sup>1</sup>H NMR for compound 16]]
'''<sup>1</sup>H NMR, <sup>13</sup>C NMR and IR of compound 16.'''
[[Image:Biomod_Aarhus_Chem_NMR_16H2.png|900x900px|Center|thumb|zoom of <sup>1</sup>H NMR for compound 16]]
[[Image:Biomod_Aarhus_Chem_NMR_16C.png|900x900px|Center|thumb|<sup>13</sup>C NMR for compound 16]]
[[Image:Biomod_Aarhus_Chem_IR16.png|900x900px|Center|thumb|IR for compound 16]]


'''<sup>1</sup>H NMR, <sup>13</sup>C NMR and IR for compound 17.'''
<html><A name="NMR16H"/></html>[[Image:Biomod_Aarhus_Chem_NMR_16H.png|900x900px|Center|thumb|<sup>1</sup>H NMR of compound 16]]
<html><br style="clear:both;"/></html>
[[Image:Biomod_Aarhus_Chem_NMR_16H2.png|900x900px|Center|thumb|zoom of <sup>1</sup>H NMR of compound 16]]
<html><br style="clear:both;"/></html>
<html><A name="NMR16C"/></html>[[Image:Biomod_Aarhus_Chem_NMR_16C.png|900x900px|Center|thumb|<sup>13</sup>C NMR of compound 16]]
<html><br style="clear:both;"/></html>
<html><A name="IR16"/></html>[[Image:Biomod_Aarhus_Chem_IR16.png|900x900px|Center|thumb|IR of compound 16]]
<html><br style="clear:both;"/></html>


[[Image:Biomod_Aarhus_Chem_NMR_17H.png|900x900px|Center|thumb|<sup>1</sup>H NMR for compound 17]]
'''<sup>1</sup>H NMR, <sup>13</sup>C NMR and IR of compound 17.'''
[[Image:Biomod_Aarhus_Chem_NMR_17H2.png|900x900px|Center|thumb|zoom of <sup>1</sup>H NMR for compound 17]]
[[Image:Biomod_Aarhus_Chem_NMR_17C.png|900x900px|Center|thumb|<sup>13</sup>C NMR for compound 17]]
[[Image:Biomod_Aarhus_Chem_IR17.png|900x900px|Center|thumb|IR for compound 17]]


'''<sup>1</sup>H NMR, <sup>13</sup>C NMR and IR for compound 18.'''
<html><A name="NMR17H"/></html>[[Image:Biomod_Aarhus_Chem_NMR_17H.png|900x900px|Center|thumb|<sup>1</sup>H NMR of compound 17]]
<html><br style="clear:both;"/></html>
[[Image:Biomod_Aarhus_Chem_NMR_17H2.png|900x900px|Center|thumb|zoom of <sup>1</sup>H NMR of compound 17]]
<html><br style="clear:both;"/></html>
<html><A name="NMR17C"/></html>[[Image:Biomod_Aarhus_Chem_NMR_17C.png|900x900px|Center|thumb|<sup>13</sup>C NMR of compound 17]]
<html><br style="clear:both;"/></html>
<html><A name="IR17"/></html>[[Image:Biomod_Aarhus_Chem_IR17.png|900x900px|Center|thumb|IR of compound 17]]
<html><br style="clear:both;"/></html>


[[Image:Biomod_Aarhus_Chem_NMR_18H.png|900x900px|Center|thumb|<sup>1</sup>H NMR for compound 18]]
'''<sup>1</sup>H NMR, <sup>13</sup>C NMR and IR of compound 18.'''
[[Image:Biomod_Aarhus_Chem_NMR_18H2.png|900x900px|Center|thumb|zoom of <sup>1</sup>H NMR for compound 18]]
[[Image:Biomod_Aarhus_Chem_NMR_18C.png|900x900px|Center|thumb|<sup>13</sup>C NMR for compound 18]]
[[Image:Biomod_Aarhus_Chem_IR18.png|900x900px|Center|thumb|IR for compound 18]]


'''<sup>1</sup>H NMR and <sup>19</sup>F NMR for compound 19.'''
<html><A name="NMR18H"/></html>[[Image:Biomod_Aarhus_Chem_NMR_18H.png|900x900px|Center|thumb|<sup>1</sup>H NMR of compound 18]]
<html><br style="clear:both;"/></html>
[[Image:Biomod_Aarhus_Chem_NMR_18H2.png|900x900px|Center|thumb|zoom of <sup>1</sup>H NMR of compound 18]]
<html><br style="clear:both;"/></html>
<html><A name="NMR18C"/></html>[[Image:Biomod_Aarhus_Chem_NMR_18C.png|900x900px|Center|thumb|<sup>13</sup>C NMR of compound 18]]
<html><br style="clear:both;"/></html>
<html><A name="IR18"/></html>[[Image:Biomod_Aarhus_Chem_IR18.png|900x900px|Center|thumb|IR of compound 18]]
<html><br style="clear:both;"/></html>


[[Image:Biomod_Aarhus_Chem_NMR_19H.png|900x900px|Center|thumb|<sup>1</sup>H NMR for compound 19]]
'''<sup>1</sup>H NMR and <sup>19</sup>F NMR of compound 19.'''
[[Image:Biomod_Aarhus_Chem_NMR_19F.png|900x900px|Center|thumb|<sup>19</sup>F NMR for compound 19]]


'''<sup>1</sup>H NMR and <sup>19</sup>F NMR for compound 21.'''
<html><A name="NMR19H"/></html>[[Image:Biomod_Aarhus_Chem_NMR_19H.png|900x900px|Center|thumb|<sup>1</sup>H NMR of compound 19]]
<html><br style="clear:both;"/></html>
<html><A name="NMR19F"/></html>[[Image:Biomod_Aarhus_Chem_NMR_19F.png|900x900px|Center|thumb|<sup>19</sup>F NMR of compound 19]]
<html><br style="clear:both;"/></html>


[[Image:Biomod_Aarhus_Chem_NMR_21H.png|900x900px|Center|thumb|<sup>1</sup>H NMR for compound 21]]
'''<sup>1</sup>H NMR and <sup>19</sup>F NMR of compound 21.'''
[[Image:Biomod_Aarhus_Chem_NMR_21F.png|900x900px|Center|thumb|<sup>19</sup>F NMR for compound 21]]
 
<html><A name="NMR21H"/></html>[[Image:Biomod_Aarhus_Chem_NMR_21H.png|900x900px|Center|thumb|<sup>1</sup>H NMR of compound 21]]
<html><br style="clear:both;"/></html>
<html><A name="NMR21F"/></html>[[Image:Biomod_Aarhus_Chem_NMR_21F.png|900x900px|Center|thumb|<sup>19</sup>F NMR of compound 21]]
<html><br style="clear:both;"/></html>


===Peptide lock===
===Peptide lock===
Line 138: Line 175:
<sup>1</sup>H NMR
<sup>1</sup>H NMR
[[Image:Exp4HNMRfinishedforrealz.png|center|thumb|900x900px|<sup>1</sup>H NMR of (S)-2-((tert-butoxycarbonyl)amino)-5-methoxy-5-oxopentanoic acid]]
[[Image:Exp4HNMRfinishedforrealz.png|center|thumb|900x900px|<sup>1</sup>H NMR of (S)-2-((tert-butoxycarbonyl)amino)-5-methoxy-5-oxopentanoic acid]]
<html><br style="clear:both;"/></html>


<sup>13</sup>C NMR
<sup>13</sup>C NMR
[[Image:Exp4CNMRfinishedforrealz.png|center|thumb|900x900px|<sup>13</sup>C NMR of (S)-2-((tert-butoxycarbonyl)amino)-5-methoxy-5-oxopentanoic acid]]
[[Image:Exp4CNMRfinishedforrealz.png|center|thumb|900x900px|<sup>13</sup>C NMR of (S)-2-((tert-butoxycarbonyl)amino)-5-methoxy-5-oxopentanoic acid]]
<html><br style="clear:both;"/></html>








 
For questions regarding raw data, please contact us by [[Biomod/2013/Aarhus/Supplementary/Team_And_Acknowledgments|email]].




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Latest revision as of 04:36, 2 November 2015

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Supplementary data

Origami design

Table S1. Details of the different modules of the plate.

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Staple strand sequences for the plate see supplementary information.


Table S2. Details of the dome structure.

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Table S3.Details of the different dome modules.

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Figure and staple strand sequences for the dome see supplementary information.



Cholesterol

1H NMR, 13C NMR and IR of compound 4.

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1H NMR 0f compound 4

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13C NMR of compound 4

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IR of compound 4

<html><br style="clear:both;"/></html> 1H NMR, 13C NMR and IR of compound 5.

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1H NMR of compound 5

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13C NMR of compound 5

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IR of compound 5

<html><br style="clear:both;"/></html> 1H NMR and 13C NMR of compound 6.

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1H NMR of compound 6

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13C NMR of compound 6

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Zoom of 13C NMR of compound 6

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Photosensitizer

1H NMR and 13C NMR of compound 7.

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1H NMR of compound 7

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13C NMR of compound 7

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1H NMR and 13C NMR of compound 8.

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1H NMR of compound 8

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13C NMR of compound 8

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1H NMR, 13C NMR and UV of compound 9.

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1H NMR of compound 9

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13C NMR of compound 9

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1H NMR, 13C NMR and UV of compound 10.

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1H NMR of compound 10

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13C NMR of compound 10

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1H NMR and 13C NMR of compound 11.

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1H NMR of compound 11

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13C NMR of compound 11

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1H NMR and 13C NMR of compound 12.

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1H NMR of compound 12

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13C NMR of compound 12

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5-propargylamino-ddUTP

1H NMR, 13C NMR and IR of compound 15.

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1H NMR of compound 15

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zoom of 1H NMR of compound 15

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13C NMR of compound 15

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IR of compound 15

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1H NMR, 13C NMR and IR of compound 16.

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1H NMR of compound 16

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zoom of 1H NMR of compound 16

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13C NMR of compound 16

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IR of compound 16

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1H NMR, 13C NMR and IR of compound 17.

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1H NMR of compound 17

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zoom of 1H NMR of compound 17

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13C NMR of compound 17

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IR of compound 17

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1H NMR, 13C NMR and IR of compound 18.

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1H NMR of compound 18

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zoom of 1H NMR of compound 18

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13C NMR of compound 18

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IR of compound 18

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1H NMR and 19F NMR of compound 19.

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1H NMR of compound 19

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19F NMR of compound 19

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1H NMR and 19F NMR of compound 21.

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1H NMR of compound 21

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19F NMR of compound 21

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Peptide lock

Spectra

(S)-2-((tert-butoxycarbonyl)amino)-5-methoxy-5-oxopentanoic acid

1H NMR

1H NMR of (S)-2-((tert-butoxycarbonyl)amino)-5-methoxy-5-oxopentanoic acid

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13C NMR

13C NMR of (S)-2-((tert-butoxycarbonyl)amino)-5-methoxy-5-oxopentanoic acid

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For questions regarding raw data, please contact us by email.


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</style> </head> <body> <div id="indexing"> <div id="sitemap"> <p id="sitemapTitle">SITEMAP | BIOMOD 2013 NANO CREATORS | Aarhus University</p> <div id="footer-contents"> <div class="footer-section"> <p class="footer-section-title">INTRODUCTION</p> <ul> <li><a href="/wiki/Biomod/2013/Aarhus">Home, abstract, animation and video</a></li> <li><a href="/wiki/Biomod/2013/Aarhus/Introduction">Introduction</a></li </ul> </div> <div class="footer-section"> <p class="footer-section-title">RESULTS AND DISCUSSION</p> <ul> <li><a href="/wiki/Biomod/2013/Aarhus/Results_And_Discussion/Origami">Origami</a></li> <li><a href="/wiki/Biomod/2013/Aarhus/Results_And_Discussion/Peptide_lock">Peptide lock</a></li> <li><a href="/wiki/Biomod/2013/Aarhus/Results_And_Discussion/Chemical_Modification">Chemical modification</a></li> <li><a href="/wiki/Biomod/2013/Aarhus/Results_And_Discussion/sisiRNA">sisiRNA</a></li> <li><a href="/wiki/Biomod/2013/Aarhus/Results_And_Discussion/System_In_Action">System in action</a></li> </ul> </div> <div class="footer-section"> <p class="footer-section-title">MATERIALS AND METHODS</p> <ul> <li><a href="/wiki/Biomod/2013/Aarhus/Materials_And_Methods/Origami">Origami</a></li> <li><a href="/wiki/Biomod/2013/Aarhus/Materials_And_Methods/Peptide_lock">Peptide lock</a></li> <li><a href="/wiki/Biomod/2013/Aarhus/Materials_And_Methods/Chemical_Modification">Chemical modification</a></li> <li><a href="/wiki/Biomod/2013/Aarhus/Materials_And_Methods/sisiRNA">sisiRNA</a></li> <li><a href="/wiki/Biomod/2013/Aarhus/Materials_And_Methods/System_In_Action">System in action</a></li> <li><a href="/wiki/Biomod/2013/Aarhus/Materials_And_Methods/Methods">Methods</a></li> </ul> </div> <div class="footer-section"> <p class="footer-section-title">SUPPLEMENTARY</p> <ul> <li><a href="/wiki/Biomod/2013/Aarhus/Supplementary/Team_And_Acknowledgments">Team and acknowledgments</a></li> <li><a href="/wiki/Biomod/2013/Aarhus/Supplementary/Optimizations">Optimizations</a></li> <li><a href="/wiki/Biomod/2013/Aarhus/Supplementary/Supplementary_Data">Supplementary data</a></li> 

                                               <li><a

href="/wiki/Biomod/2013/Aarhus/Supplementary/Supplementary_Informations">Supplementary informations</a> <li><a href="/wiki/Biomod/2013/Aarhus/Supplementary/References">References</a></li> </ul> </div> </div> <div> <p id="copyright">Copyright (C) 2013 | BIOMOD Team Nano Creators @ Aarhus University | Programming by: <a href="mailto:pvskaarup@gmail.com?Subject=BIOMOD 2013:">Peter Vium Skaarup</a>.</p> </div> </div>

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