Biomod/2013/BITS

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[[Image:[[Image:BITSMOD LOGO.png]]]]
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<head>
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<meta charset="UTF-8">
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<title>BITSMOD</title>
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margin-top: -1px;
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background: transparent url(style/images/footer-line.png) repeat-x top center;
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margin-top: 40px;
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margin-top: 15px;
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background: none;
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line-height: 1.1;
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margin-bottom: 5px;
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.footer-box ul.popular-posts li h5 a, .secondary .sidebox ul.popular-posts li h5 a {
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color: #4a4a4a;
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-
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.footer-box ul.popular-posts li h5 a:hover, .secondary .sidebox ul.popular-posts li h5 a:hover {
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-
color: #ab4d63;
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.footer-box ul.popular-posts li span a, .secondary .sidebox ul.popular-posts li span a {
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color: #585858;
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.footer-box ul.popular-posts li span a:hover, .secondary .sidebox ul.popular-posts li span a:hover {
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color: #ab4d63;
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-
 
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-
 
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-
 
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+
-
/*-----------------------------------------------------------------------------------*/
+
-
/* MENU
+
-
/*-----------------------------------------------------------------------------------*/
+
-
 
+
-
#menu {
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-
float: left;
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-
text-align: left;
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-
font-family: 'Amaranth', sans-
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-
 
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-
serif;
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-
font-size: 20px;
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-
margin-top: 40px;
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-
margin-bottom: 50px;
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position: relative;
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z-index: 100;
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padding: 0 0 0 24px;
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text-shadow: 0px 1px
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0px rgba(0, 0, 0, 0.5);
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padding: 0;
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list-style-type: none;
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-
width: 200px;
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background:#d1994a no-repeat center bottom;
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li{
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padding-right: 5px;
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-
background:#ddb379  no-repeat center top;
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text-decoration: none;
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padding: 12px 0 10px 20px;
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padding-right: 17px;
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color:#f9f1e6 ;
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text-decoration: none;
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border: none;
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text-decoration: none;
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background: transparent url(style/images/menu-hover.png)
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repeat-y left top;
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color: #fff;
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position: absolute;
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width: 130px;
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<div id="logo"><a href="http://openwetware.org/wiki/Biomod/2013/BITS"><img src="[[Image:sidelogo.png]]" alt="aayush" /></a></div>
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<ul>
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            <li><a href="http://openwetware.org/wiki/Biomod/2013/BITS" >Home</a></li></u1>
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            <li><a href="http://openwetware.org/wiki/Biomod/2013/BITS/background" >Background</a></li>
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  <li><a href="http://openwetware.org/wiki/Biomod/2013/BITS/project1">Project</a></li>
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<li><a href="http://openwetware.org/wiki/Biomod/2013/BITS/design">Design</a></li>
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        <li><a href="http://openwetware.org/wiki/Biomod/2013/BITS/protocol">Protocols</a></li>
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                <li><a href="http://openwetware.org/wiki/Biomod/2013/BITS/simulation">Simulation</a></li>
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<li><a href="http://openwetware.org/wiki/Biomod/2013/BITS/results">Results</a></li>             
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  <h1 class="title">Biomimetics at nanoscale: DNA origami to deliver IRES aptamers using HCV as a template</h1>
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<h2>Abstract</h2>
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<div class="intro">With its worldwide distribution, Hepatitis C Virus (HCV) infects about 3-4 million people every year of which the chronically infected ones are at a
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risk of developing liver cirrhosis, hepatic failure or hepatocellular carcinoma. The limited availability and poor tolerance towards antiviral therapy and interferon
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with ribavirin (nucleoside inhibitor) demands a different approach towards targeting the HCV infection. Research indicates that the HCV genome translation is under the
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control of the Internal Ribosomal Entry Site (IRES) which mediates cap-independent internal initiation of HCV polyprotein translation thereby making it a
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quintessential target to halt and thereby curb the infection. Nucleic acid ligands generated using SELEX (Systematic Evolution of Ligands by EXponential enrichment)
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called aptamers, are the recent class of molecules showing immense potential to be crafted for binding to multiple different targets. First proposed by Seeman and
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started by Rothemund, DNA origami is based on the principle that a long ssDNA scaffold can be molded into any desired shape using staples. With this method of
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tailoring DNA nanostructures, the self assembling property of nucleic acids would be exploited for the delivery of IRES specific aptamers to the HCV infected cells. We
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designed a cylindrical nanostructure mimicking HCV by attaching E1-E2 conjugate peptide sequences, facilitating the entry via endosomal pathway; and by using pH
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sensitive detachable lids to release the IRES aptamers packed inside the nanostructure to the infected cells. The aptamer based silencing of viral translation will in
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turn prevent the assembly of new viroids and serve as a mechanism to control the HCV infection.</div>
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Revision as of 17:26, 13 October 2013

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