Biomod/2013/IIT-Madras/Project: Difference between revisions
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== Background == | |||
DNA walkers are nanomachines which exhibit linear motion along a DNA strand. It was initially constructed with the aim of mimicking the intracellular motion of molecular motors such as kinesin so that these can in turn serve as mechanical parts for future Nano-bots. It mainly consists of two strands - a moving strand and a stationary strand along which the moving strand "walks". The major components of the DNA walker system are: | |||
# Walker (the moving strand) | |||
# Track (the stationary strand) | |||
# Attachment strands/Set strands : These hybridize to single stranded segments thereby linking them. | |||
# Detachment strands/Unset strands : Displace the set strands as these greater affinity. | |||
There have been several modifications to this construct over the past decade like the use of Nicking enzyme to power the unidirectional motion of DNA fragment, autonomously. | |||
In this project, we demonstrate the displacement of DNA in response to stimuli such as pH change. | |||
Revision as of 10:37, 22 October 2013
Background
DNA walkers are nanomachines which exhibit linear motion along a DNA strand. It was initially constructed with the aim of mimicking the intracellular motion of molecular motors such as kinesin so that these can in turn serve as mechanical parts for future Nano-bots. It mainly consists of two strands - a moving strand and a stationary strand along which the moving strand "walks". The major components of the DNA walker system are:
- Walker (the moving strand)
- Track (the stationary strand)
- Attachment strands/Set strands : These hybridize to single stranded segments thereby linking them.
- Detachment strands/Unset strands : Displace the set strands as these greater affinity.
There have been several modifications to this construct over the past decade like the use of Nicking enzyme to power the unidirectional motion of DNA fragment, autonomously.
In this project, we demonstrate the displacement of DNA in response to stimuli such as pH change.
