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<h2>Future</h2> Lipo-Hanabi is able to release a lot of molecules anytime and anywhere. Such versatility is essential in potential applications as follows.<br>

<h3>Example 1 Sensing and curing inflammations in blood vessels</h3> Inflammation in blood vessels is a typical symptom difficult to diagnose. Therefore, they could get worse while you don’t even notice it.<br> The only way to detect blood vessel inflammation is to do a constant physical checkup. Lipo-Hanabi enables us to detect inflammations easily and gives us enough time to cure them. <br> Specific design will be as follows. C-reactive protein (CRP) is released in the inflammation. So we can use Liposomes conjugated with phosphorylcholine (one of phosphatides react with CRP) as the 1st stage detector for Lipo-Hanabi system. Then the 2nd stage liposomes release medicine at inflammation area effectively.<br>

Applications of Lipo-Hanabi are not limited to inflammations. As it can sense even very faint trigger signal and release large amount of drugs, it would help us to detect cancer cells in early stage while they are curable with small amount of anti-cancer agents.<br><br>

<br> <div align="center"> <img src="http://openwetware.org/images/b/b9/%E3%83%97%E3%83%AD%E3%82%B8%E3%82%A7%E3%82%AF%E3%83%88%EF%BC%92lkjg.png" width="65%" height="65%"><br> Fig.1 Sensing and curing inflammations in blood vessels </div>

<h3>Example 2 molecular fuel supply</h3>

Focusing on the chain-reaction, Lipo-Hanabi can be applied to long-lasting batteries for molecular engines. If fuel for the molecular engines (such as ATP) is packed inside the liposome, they can constantly supply fuels to the molecular motor by a specific external signal. This kind of fuel supply system will be very useful to realize self-sustained molecular robots in the future.<br>

<div align="center"> <img src="http://openwetware.org/images/6/6a/Molecular-engineklug.png" width="95%" ><br> Fig. 2 Molecular fuel supply system</div>

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@@ Line 49: / Line 49: @@
 <h2>Future</h2>
-The advantage of our system is that large quantity of substances can be released in any limited place at any timing. <br>
+Lipo-Hanabi is able to release a lot of molecules anytime and anywhere.
-<!--私たちのプロジェクトを応用すれば以下のようなことが実現できる可能性がある<br>-->
+Such versatility is essential in potential applications as follows.<br>
-<br>Our project will realize the following application.
-<img src=""><br><br>
-<h3>Example 1 <!--血管の炎症の感知と治療<br> -->Sensing and curing inflammations in blood vessels</h3>
+<br><br>
-<!--
+<h3>Example 1 Sensing and curing inflammations in blood vessels</h3>
-自分の血管で起こっている炎症の中には痛みを感じず、自分の知らない間に悪化してしまう。<br>
+Inflammation in blood vessels is a typical symptom difficult to diagnose. Therefore, they could get worse while you don’t even notice it.<br>
-これらのシグナルを早期に発見するためには検査回数を増やすという方法しかなかった。
+The only way to detect blood vessel inflammation is to do a constant physical checkup. Lipo-Hanabi enables us to detect inflammations easily and gives us enough time to cure them. <br>
-私たちのプロジェクトを応用すれば無自覚に進行している炎症を早期に発見して治療することができそうだ。<br>
+Specific design will be as follows. C-reactive protein (CRP) is released in the inflammation. So we can use Liposomes conjugated with phosphorylcholine (one of phosphatides react with CRP) as the 1st stage detector for Lipo-Hanabi system. Then the 2nd stage liposomes release medicine at inflammation area effectively.<br>
-血管の炎症からはＣ－反応性タンパク質（ＣＲＰ）というシグナルが出ている。<br>
-ファーストステージでは表面にホスホリルコリン（ＣＲＰと反応するリン脂質の一種）を含むリポソームが炎症部位を感知して割れる。内部の鍵DNAが放出される。<br>
+Applications of Lipo-Hanabi are not limited to inflammations. As it can sense even very faint trigger signal and release large amount of drugs, it would help us to detect cancer cells in early stage while they are curable with small amount of anti-cancer agents.<br><br>
-セカンドステージでは鍵DNAがハイブリすることで割れる。内部に薬を入れておくことで狭い炎症部位に効果的に薬分子を放出できる。<br><br>
--->
-As it is hard to recognize inflammations in blood vessels, they could get worse while you don’t know. <br>
-The only way to detect these inflammations has been undergoing physical checkups constantly. However, our project would enables us to detect these inflammations and gives us to enough time to cure them.
-In the case of inflammations in blood vessels, C-reactive protein (CRP) is released.
-Liposomes conjugated with phosphorylcholine (one of phosphatides; it reacts CRP) sense the inflammation area, breaks and release the key DNAs there. <br>
-Then, the released key DNAs hybridize and break other liposomes. By confining medicines in the liposomes, you can release them at narrow inflammation area effectively. <br><br>
-<!--血管の炎症だけでなく無自覚に進行してしまうガンなどの治療やにも使えるだろう。-->
-The application is not limited to inflammations. Our project would also offer effective treatment for cancer. As it can sense even unrecognizable trigger signal and releases large amount of drugs in a limited space, it would help us to detect cancer cells early and prevent side effects by anti-cancer agents.
-<br>
 <br>
 <div align="center">
-<img src="http://openwetware.org/images/5/50/%E3%83%97%E3%83%AD%E3%82%B8%E3%82%A7%E3%82%AF%E3%83%88%EF%BC%92tyui.png" width="75%" height="75%"><br>
+<img src="http://openwetware.org/images/b/b9/%E3%83%97%E3%83%AD%E3%82%B8%E3%82%A7%E3%82%AF%E3%83%88%EF%BC%92lkjg.png" width="65%" height="65%"><br>
-Fig1.Sensing and curing inflammations in blood vessels
+Fig.1 Sensing and curing inflammations in blood vessels
 </div>
-<h3>Example 2 molecular engine</h3>
-Moreover, focusing on the chain reaction, our system can be applied to long-lasting batteries for molecular engines.
-If some fuel for molecular engines (such as ATP) is packed inside the liposome, and the liposome is combined with some molecular motors (such as motor proteins), the fuel can be constantly supplied to the molecular motor by only one time initiation of the reaction. <br>
-The molecular motor would lead to molecular engines, and in the end, sophisticated molecular robots. Our system would make it possible to achieve molecular robots moving without continuous fuel supply from the outside.<br><br>
+<h3>Example 2 molecular fuel supply</h3>
+Focusing on the chain-reaction, Lipo-Hanabi can be applied to long-lasting batteries for molecular engines. If fuel for the molecular engines (such as ATP) is packed inside the liposome, they can constantly supply fuels to the molecular motor by a specific external signal. This kind of fuel supply system will be very useful to realize self-sustained molecular robots in the future.<br>
 <div align="center">
-<img src="http://openwetware.org/images/3/31/Future2.png" width="70%">
+<img src="http://openwetware.org/images/6/6a/Molecular-engineklug.png" width="95%" ><br>
-Fig2.Molecular engine</div>
+Fig. 2 Molecular fuel supply system</div>
          </article>

Biomod/2013/Sendai/future: Difference between revisions

Latest revision as of 22:59, 26 October 2013

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