Biomod/2014/UCR/Breaking RNA: Difference between revisions

Revision as of 16:12, 29 September 2014

 <head>
   <meta http-equiv="Content-Type" content="text/html; charset=UTF-8" />
   <meta name="Generator" content="iWeb 3.0.4" />
   <meta name="iWeb-Build" content="local-build-20140929" />
   <meta http-equiv="X-UA-Compatible" content="IE=EmulateIE7" />
   <meta name="viewport" content="width=700" />
   <title>Abstract</title>
   <link rel="stylesheet" type="text/css" media="screen,print" href="http://www.cs.ucr.edu/~makho001/kimia/Home.css" />
   <!--[if lt IE 8]><link rel='stylesheet' type='text/css' media='screen,print' href='http://www.cs.ucr.edu/~makho001/kimia/HomeIE.css'/><![endif]-->
   <!--[if gte IE 8]><link rel='stylesheet' type='text/css' media='screen,print' href='Media/IE8.css'/><![endif]-->
   <style type="text/css"> <!--

@import "Scripts/Widgets/YouTube/YouTube.css"; --></style>

   <script type="text/javascript" src="Scripts/iWebSite.js"></script>
   <script type="text/javascript" src="Scripts/Widgets/SharedResources/WidgetCommon.js"></script>
   <script type="text/javascript" src="Scripts/Widgets/Navbar/navbar.js"></script>
   <script type="text/javascript" src="Scripts/iWebImage.js"></script>
   <script type="text/javascript" src="Scripts/iWebMediaGrid.js"></script>
   <script type="text/javascript" src="Scripts/Widgets/YouTube/YouTube.js"></script>
   <script type="text/javascript" src="Scripts/Widgets/YouTube/localizedStrings.js"></script>
   <script type="text/javascript" src="http://www.cs.ucr.edu/~makho001/kimia/Home.js"></script>
   <style>
   .paragraph_style {
   color: rgb(80, 80, 77);
   font-family: 'HoeflerText-Regular', 'Hoefler Text', 'Times New Roman', serif;
   font-size: 12px;
   font-stretch: normal;
   font-style: normal;
   font-variant: normal;
   font-weight: 400;
   letter-spacing: 0;
   line-height: 17px;
   margin-bottom: 0px;
   margin-left: 0px;
   margin-right: 0px;
   margin-top: 0px;
   opacity: 1.00;
   padding-bottom: 0px;
   padding-top: 0px;
   text-align: justify;
   text-decoration: none;
   text-indent: 0px;
   text-transform: none;

} .paragraph_style_1 {

   color: rgb(80, 80, 77);
   font-family: 'HoeflerText-Regular', 'Hoefler Text', 'Times New Roman', serif;
   font-size: 14px;
   font-stretch: normal;
   font-style: normal;
   font-variant: normal;
   font-weight: 400;
   letter-spacing: 0;
   line-height: 20px;
   margin-bottom: 0px;
   margin-left: 0px;
   margin-right: 0px;
   margin-top: 0px;
   opacity: 1.00;
   padding-bottom: 0px;
   padding-top: 0px;
   text-align: left;
   text-decoration: none;
   text-indent: 0px;
   text-transform: none;

} .style_SkipStroke_1 {

   background: transparent;
   opacity: 1.00;

} .style_SkipStroke_2 {

   background: transparent;
   opacity: 1.00;

} .style_SkipStroke_3 {

   background: transparent;
   opacity: 1.00;

} .style_SkipStroke_4 {

   background: transparent;
   opacity: 1.00;

} .style_SkipStroke {

   background: transparent;
   opacity: 1.00;

} .Body {

   color: rgb(80, 80, 77);
   font-family: 'HoeflerText-Regular', 'Hoefler Text', 'Times New Roman', serif;
   font-size: 12px;
   font-stretch: normal;
   font-style: normal;
   font-variant: normal;
   font-weight: 400;
   letter-spacing: 0;
   line-height: 17px;
   margin-bottom: 0px;
   margin-left: 0px;
   margin-right: 0px;
   margin-top: 0px;
   opacity: 1.00;
   padding-bottom: 0px;
   padding-top: 0px;
   text-align: left;
   text-decoration: none;
   text-indent: 0px;
   text-transform: none;

} .Free_Form {

   color: rgb(80, 80, 77);
   font-family: 'HoeflerText-Regular', 'Hoefler Text', 'Times New Roman', serif;
   font-size: 12px;
   font-stretch: normal;
   font-style: normal;
   font-variant: normal;
   font-weight: 400;
   letter-spacing: 0;
   line-height: 17px;
   margin-bottom: 0px;
   margin-left: 0px;
   margin-right: 0px;
   margin-top: 0px;
   opacity: 1.00;
   padding-bottom: 0px;
   padding-top: 0px;
   text-align: left;
   text-decoration: none;
   text-indent: 0px;
   text-transform: none;

} .Normal {

   padding: 0px;

} .Normal_External_166_28 {

   position: relative;

} .Normal_External_603_184 {

   position: relative;

} .Normal_External_191_40 {

   position: relative;

} .Normal_External_74_25 {

   position: relative;

} .Title {

   color: rgb(80, 80, 77);
   font-family: 'HoeflerText-Regular', 'Hoefler Text', 'Times New Roman', serif;
   font-size: 18px;
   font-stretch: normal;
   font-style: normal;
   font-variant: normal;
   font-weight: 400;
   letter-spacing: 0;
   line-height: 26px;
   margin-bottom: 0px;
   margin-left: 0px;
   margin-right: 0px;
   margin-top: 0px;
   opacity: 1.00;
   padding-bottom: 0px;
   padding-top: 0px;
   text-align: left;
   text-decoration: none;
   text-indent: 0px;
   text-transform: none;

} .graphic_generic_body_textbox_style_default_SkipStroke {

   background: transparent;
   opacity: 1.00;

} .graphic_generic_title_textbox_style_default_SkipStroke {

   background: transparent;
   opacity: 1.00;

} .graphic_image_style_default_SkipStroke {

   background: transparent;
   opacity: 1.00;

} .graphic_textbox_layout_style_default {

   padding: 4px;

} .graphic_textbox_layout_style_default_External_210_24 {

   position: relative;

} .graphic_textbox_layout_style_default_External_100_100 {

   position: relative;

} .graphic_textbox_style_default_SkipStroke {

   background: transparent;
   opacity: 1.00;

}

widget1 a {

   color: rgb(147, 141, 122);
   text-decoration: underline;

}

widget0 a:hover {

   color: rgb(80, 80, 77);
   text-decoration: underline;

}

widget1 a:hover {

   color: rgb(80, 80, 77);
   text-decoration: underline;

}

widget0 a:visited {

   color: rgb(147, 141, 122);
   text-decoration: underline;

}

widget0 a {

   color: rgb(147, 141, 122);
   text-decoration: underline;

}

widget1 a:visited {

   color: rgb(147, 141, 122);
   text-decoration: underline;

} .spacer {

   font-size: 1px;
   line-height: 1px;

} .tinyText {

   font-size: 1px;
   line-height: 1px;

} .bumper {

   font-size: 1px;
   line-height: 1px;

} body {

   -webkit-text-size-adjust: none;

} div {

   overflow: visible;

} img {

   border: none;

} .InlineBlock {

   display: inline;

} .InlineBlock {

   display: inline-block;

} .inline-block {

   display: inline-block;
   vertical-align: baseline;
   margin-bottom:0.3em;

} .inline-block.shape-with-text {

   vertical-align: bottom;

} .vertical-align-middle-middlebox {

   display: table;

} .vertical-align-middle-innerbox {

   display: table-cell;
   vertical-align: middle;

} div.paragraph {

   position: relative;

} li.full-width {

   width: 100;

} </style>

 </head>
 <body style="background: rgb(255, 255, 255) url(http://www.cs.ucr.edu/~makho001/kimia/Creme_browserbg.jpg) repeat scroll top left; margin: 0pt; " onload="onPageLoad();" onunload="onPageUnload();">
   <div style="text-align: center; ">
     <div style="margin-bottom: 20px; margin-left: auto; margin-right: auto; margin-top: 20px; overflow: hidden; position: relative; word-wrap: break-word;  text-align: left; width: 700px; " id="body_content">
       <div style="background: transparent url(http://www.cs.ucr.edu/~makho001/kimia/LayeredPaper_03-1.jpg) repeat scroll top left; width: 700px; ">
         <div style="height: 50px; margin-left: 0px; position: relative; width: 700px; z-index: 5; " id="header_layer">
           <div style="height: 0px; line-height: 0px; " class="bumper"> </div>
           <div style="height: 248px; width: 700px;  height: 248px; left: 0px; position: absolute; top: 0px; width: 700px; z-index: 1; " class="tinyText style_SkipStroke">
             <img src="http://www.cs.ucr.edu/~makho001/kimia/LayeredPaper_01.jpg" alt="" style="border: none; height: 248px; width: 700px; " />
           </div>
         </div>
         <div style="margin-left: 0px; position: relative; width: 700px; z-index: 10; " id="nav_layer">
           <div style="height: 0px; line-height: 0px; " class="bumper"> </div>
           <div style="height: 106px; width: 201px;  height: 106px; left: 157px; position: absolute; top: -31px; width: 201px; z-index: 1; " class="tinyText style_SkipStroke_1">
             <img src="http://openwetware.org/images/8/87/Banner.png" alt="" style="border: none; height: 106px; width: 201px; " />
           </div>

           <div id="id1" style="height: 24px; left: 465px; position: absolute; top: 60px; width: 210px; z-index: 1; " class="style_SkipStroke_2 shape-with-text">
             <div class="text-content graphic_textbox_layout_style_default_External_210_24" style="padding: 0px; ">
               <div class="graphic_textbox_layout_style_default">
                 <p style="padding-bottom: 0pt; padding-top: 0pt; " class="Free_Form">University of California, Riverside</p>
               </div>
             </div>
           </div>

           <div style="height: 2px; width: 622px;  height: 1px; left: 21px; position: absolute; top: 89px; width: 622px; z-index: 1; " class="tinyText">
             <div style="position: relative; width: 622px; ">
               <img src="http://www.cs.ucr.edu/~makho001/kimia/shapeimage_1.jpg" alt="" style="height: 2px; left: 0px; margin-top: -1px; position: absolute; top: 0px; width: 622px; " />
             </div>
           </div>
           <div style="height: 1px; line-height: 1px; " class="tinyText"> </div>
           <div class="com-apple-iweb-widget-navbar flowDefining" id="widget0" style="margin-left: 145px; margin-top: 94px; opacity: 1.00; position: relative; width: 375px; z-index: 1; ">
   
             <div id="widget0-navbar" class="navbar">

               <div id="widget0-bg" class="navbar-bg">

                 <ul id="widget0-navbar-list" class="navbar-list">
<li></li>

</ul>

</div>

           </div>
           <script type="text/javascript"><!--//--><![CDATA[//><!--

new NavBar('widget0', 'Scripts/Widgets/Navbar', 'Scripts/Widgets/SharedResources', '.', {"path-to-root": "", "navbar-css": ".navbar {\n\tfont-family: 'Hoefler Text', 'Times New Roman', serif;\n\tfont-size: .9em;\n\tcolor: #817B67;\n\tmargin: 0px;\n\tline-height: 25px;\n}\n\n.navbar-bg {\n\ttext-align: left;\n}\n\n.navbar-bg ul {\n\tlist-style: none;\n\tmargin: 0px;\n\tpadding: 0px;\n}\n\n\nli {\n\tlist-style-type: none;\n\tdisplay: inline;\n\tpadding: 0 25px 0 0px;\n}\n\n\nli a {\n\ttext-decoration: none;\n\tpadding: 0px;\n\tcolor: #817B67;\n}\n\nli a:visited {\n\ttext-decoration: none;\n\tpadding: 0px;\n\tcolor: #817B67;\n}\n\nli a:hover\r{\r\n \tcolor: #3F3F3C;\n\ttext-decoration: none;\r}\n\n\nli.current-page a\r{\r\t color: #3F3F3C;\n\ttext-decoration: none;\r}", "current-page-GUID": "67962F4E-DB92-4A18-84A6-3A86890A69FC", "isCollectionPage": "NO"}); //--><!]]></script>

           <div style="clear: both; height: 0px; line-height: 0px; " class="spacer"> </div>
         </div>
         <div style="margin-left: 0px; position: relative; width: 700px; z-index: 15; " id="body_layer">
           <div style="height: 0px; line-height: 0px; " class="bumper"> </div>
           <div style="height: 1px; line-height: 1px; " class="tinyText"> </div>
           <div style="margin-left: 31px; margin-top: 43px; position: relative; width: 603px; z-index: 1; " class="style_SkipStroke_3 shape-with-text flowDefining">
             <div class="text-content Normal_External_603_184" style="padding: 0px; ">
               <div class="Normal">
                 <p style="padding-top: 0pt; " class="paragraph_style">Oscillators, nature’s biological clocks, have important applications ranging from maintaining a circadian rhythm to regulating hormonal levels. We are constructing a synthetic in vitro oscillatory network. In vitro oscillators have been constructed in the past; however, our system is the first to utilize RNA aptamers that allow for a simpler, yet robust oscillator. Our theoretical model for this oscillatory scheme shows that it is capable of having robust oscillations. On the experimental front, we have shown that our RNA polymerase enzymes can be inhibited and reactivated by the binding and removal of the aptamers respectively. This would be an important step towards our goal of experimentally validating the oscillatory scheme. We hope that the simplicity of our system allows it to be easily built upon, thus, paving the way for a new set of biological circuits and this would introduce RNA aptamers as a powerful tool for programmable, synthetic circuits.<br /></p>
                 <p class="paragraph_style"> <br /></p>
               </div>
               <div style="height: 15px; line-height: 15px; " class="tinyText"> </div>
             </div>
           </div>

           <div id="id2" style="height: 25px; left: 313px; position: absolute; top: 19px; width: 74px; z-index: 1; " class="style_SkipStroke_4 shape-with-text">
             <div class="text-content Normal_External_74_25" style="padding: 0px; ">
               <div class="Normal">
                 <p style="padding-bottom: 0pt; padding-top: 0pt; " class="paragraph_style_1">Abstract</p>
               </div>
             </div>
           </div>

           <div id="id3" style="height: 100px; left: 308px; position: absolute; top: 316px; width: 100px; z-index: 1; " class="style_SkipStroke_2 shape-with-text">
             <div class="text-content graphic_textbox_layout_style_default_External_100_100" style="padding: 0px; ">
               <div class="graphic_textbox_layout_style_default"></div>
             </div>
           </div>

           <div style="height: 2px; width: 622px;  height: 1px; left: 21px; position: absolute; top: 0px; width: 622px; z-index: 1; " class="tinyText">
             <div style="position: relative; width: 622px; ">
               <img src="http://www.cs.ucr.edu/~makho001/kimia/shapeimage_2.jpg" alt="" style="height: 2px; left: 0px; margin-top: -1px; position: absolute; top: 0px; width: 622px; " />
             </div>
           </div>

           <div id="id4" style="height: 28px; left: 275px; position: absolute; top: 568px; width: 166px; z-index: 1; " class="style_SkipStroke_4 shape-with-text">
             <div class="text-content Normal_External_166_28" style="padding: 0px; ">
               <div class="Normal">
                 <p style="padding-bottom: 0pt; padding-top: 0pt; " class="paragraph_style_1">RNA Clocks and Switches</p>
               </div>
             </div>
           </div>

           <div id="id5" style="height: 40px; left: 254px; position: absolute; top: 203px; width: 191px; z-index: 1; " class="style_SkipStroke_4 shape-with-text">
             <div class="text-content Normal_External_191_40" style="padding: 0px; ">
               <div class="Normal">
                 <p style="padding-bottom: 0pt; padding-top: 0pt; " class="paragraph_style_1">A Synthetic Oscillatory System</p>
               </div>
             </div>
           </div>
           <div class="com-apple-iweb-widget-YouTube aboveStrokesAndFrames" id="widget1" style="height: 346px; left: 143px; opacity: 1.00; position: absolute; top: 601px; width: 414px; z-index: 1; ">
             <div id="widget1-youTube" class="youtube_widget"></div>
           </div>
           <script type="text/javascript"><!--//--><![CDATA[//><!--

new YouTubeWidget('widget1', 'Scripts/Widgets/YouTube', 'Scripts/Widgets/SharedResources', '.', {"showRelatedVideos": true, "address": ""}); //--><!]]></script>

           <div style="height: 719px; line-height: 719px; " class="spacer"> </div>
         </div>
         <div style="height: 120px; margin-left: 0px; position: relative; width: 700px; z-index: 0; " id="footer_layer">
           <div style="height: 0px; line-height: 0px; " class="bumper"> </div>
           <div style="height: 236px; width: 700px;  height: 236px; left: 0px; position: absolute; top: -116px; width: 700px; z-index: 1; " class="tinyText style_SkipStroke">
             <img src="http://www.cs.ucr.edu/~makho001/kimia/LayeredPaper_04.jpg" alt="" style="border: none; height: 236px; width: 700px; " />
           </div>
         </div>
       </div>
     </div>
   </div>
 </body>

</html>

Biomod/2014/UCR/Breaking RNA: Difference between revisions

Revision as of 16:12, 29 September 2014

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

research

Tools