Biomod/2014/fit Results and Discussion.html: Difference between revisions
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Revision as of 11:20, 25 October 2014
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Preliminary Experiment: verification of FRET with the ssDNAs not modified to the silica
Fig. 9a and 9b shows the photograph and the SEM image of the amino-functionalized mesoporous silica (MPS-NH2) particle. Spherical particles with the diameter of about 300 nm to 1000 nm are observed. However, because the size of the mesopores is too small, assumed as 2 nm, we could not observed the pores. After the modification with -COOH group (Fig. 9c) and with DNA (Fig. 9d), there were no significant changes in SEM. Therefore, it is understood that the shape of former particle is maintained.
We create “nano Pop-up Pirate “using by the complementary DNA base-pairing. Pop-up Pirate is a famous Japanese toy. A doll is sitting on the Barrel. Players stab the sword to when player stabs to the specific point, the doll will fly away from a barrel.
Fluorescence labeled DNA was bound to the porous silica particle, of the barrel. And different fluorescence labeled mismatched DNA who is a doll in bound to the Barrel DNA. When mismatched DNA that is a sward in added, mismatched DNA would be released.
Two fluorescence reagents are constructed the FRET system, and used in the detection of the states of DNAs. This system is applicable for the Drug Delivery systems .A porous silica is a container .DNA system is a drug release regulation. Free system is a drug release detection.
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<img alt="" src="/images/0/0b/Fitfisilica.png" width="350" height="350" border="0" /> figure1 |
<img alt="" src="/images/4/4c/Fitkspec.png" width="350" height="350" border="0" /> figure2 |
<img alt="" src="/images/1/16/FitsilicaT.png" width="250" height="250" border="0" /> figure3-1 |
<img alt="" src="/images/4/48/FitsilicaF.png" width="250" height="250" border="0" /> figure3-2 |
<img alt="" src="/images/0/09/FitsilicaTF.png" width="250" height="250" border="0" /> figure3-3 |
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