Birbach:Research

From OpenWetWare

(Difference between revisions)
Jump to: navigation, search
Line 14: Line 14:
=Projects=
=Projects=
 +
 +
==Inflammation in prostate tumorigenesis==
 +
 +
This project is funded by the Austrian Science fund [http://www.fwf.ac.at FWF], project [http://www.fwf.ac.at/en/abstracts/abstract.asp?L=E&PROJ=P21919 P21919-B13].
 +
Inflammation is thouht to have a causative role in about 20% of human cancers. In prostate cancer, epidemioloical data sugest a link between chronic inflammation and early events in tumorigenesis, although a proof of this concept in a genetic model is lacking. In this project, we have established a mouse model combining monoallelic loss of the tumor suppressor PTEN together with expression of a constitutively active version of the IkappaB kinase 2 (IKK2) in prostate epithelial cells. We find that these double transgenic mice exhibit proliferative neoplasia (PIN) with large tumors, in contrast to non-enalrged

Revision as of 04:41, 16 August 2011

Home        Contact        Internal        Lab Members        Publications        Research        Talks       


}

Projects

Inflammation in prostate tumorigenesis

This project is funded by the Austrian Science fund FWF, project P21919-B13. Inflammation is thouht to have a causative role in about 20% of human cancers. In prostate cancer, epidemioloical data sugest a link between chronic inflammation and early events in tumorigenesis, although a proof of this concept in a genetic model is lacking. In this project, we have established a mouse model combining monoallelic loss of the tumor suppressor PTEN together with expression of a constitutively active version of the IkappaB kinase 2 (IKK2) in prostate epithelial cells. We find that these double transgenic mice exhibit proliferative neoplasia (PIN) with large tumors, in contrast to non-enalrged

Personal tools