Bistability: Difference between revisions
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Bistability is a particular case of multistability, the property of a system to reside in different stable steady-states without being able to rest in intermediate states [1]. | Bistability is a particular case of multistability, the property of a system to reside in different stable steady-states without being able to rest in intermediate states [1]. | ||
= | ==Properties of bistable systems== | ||
*Feedback | *Feedback | ||
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*Hysteresis | *Hysteresis | ||
One of the key. History dependent behavior, kind of memory. An example of thermal hysteresis is the melting of agarose as stated in [3]. | One of the key. History dependent behavior, kind of memory (http://en.wikipedia.org/wiki/Hysteresis#Cell_biologysee also here). An example of thermal hysteresis is the melting of agarose as stated in [3]. | ||
In biology, key example include the lactose operon, or the activation of cdc2-cyclinB1. In both case the system requires less stimulus to maintain the state than for switching to this state. | In biology, key example include the lactose operon, or the activation of cdc2-cyclinB1. In both case the system requires less stimulus to maintain the state than for switching to this state. The refractory period in neuron stimulation is also a good example (http://en.wikipedia.org/wiki/Refractory_period_(physiology) here). | ||
Revision as of 21:27, 17 December 2008
Bistability is a particular case of multistability, the property of a system to reside in different stable steady-states without being able to rest in intermediate states [1].
Properties of bistable systems
- Feedback
Often, bistable states are maintained by the help of positive feedback, negative feedback on the other sate players, self-catalysis.First decribed by Monod and Jacob in 1961 [2]. Often found in combination.
- Ultrasensitivity
Characteristic of the system to respond to stimulus in a non linear fashion, contribute to a "all or none" behavior. Ultrasensitivity can arise by multiple ways, including cooperativity. It account for the emergence of threshold levels of activation of a given transition.
- Hysteresis
One of the key. History dependent behavior, kind of memory (http://en.wikipedia.org/wiki/Hysteresis#Cell_biologysee also here). An example of thermal hysteresis is the melting of agarose as stated in [3]. In biology, key example include the lactose operon, or the activation of cdc2-cyclinB1. In both case the system requires less stimulus to maintain the state than for switching to this state. The refractory period in neuron stimulation is also a good example (http://en.wikipedia.org/wiki/Refractory_period_(physiology) here).
