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('''Yoonhee Kim, MPH, Ph.D''')
(Yoonhee Kim, M.P.H, Ph.D.)
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== '''Yoonhee Kim, MPH, Ph.D''' ==
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== '''Yoonhee Kim, M.P.H, Ph.D.''' ==
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[[image:YK1.jpg|200px]]
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== RESEARCH INTEREST ==
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Postdoctoral fellow
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Statistical Genetics, Genetic Epidemiology
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Genometrics section (Dr. Alexander F. Wilson)
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Next Generation Sequencing data analysis, GenexGene Interaction analysis using Machine Learning Methods (Random Forests)
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Inherited Disease Research Branch
 
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National Human Genome Research Institute
 
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National Institute of Health
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== EDUCATION ==
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Email : '''wondernina@hotmail.com'''
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2008 Ph.D. Seoul National University, School of Public Health
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Tel: (410) 550-7125
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2003 M.P.H Seoul National University, School of Public Health
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Fax: (410) 550-7513
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2001 B.S.  Ewha Womans Univerisity
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== '''Education''' ==
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== PUBLICATION ==
 +
(* co-first author)
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* 1997 - 2001 BS in Statistics, and BS in Biology, Ewha Women's University, Seoul, Korea
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K. C. Desch, A. B. Ozel, D. Siemieniak, Y. Kalish, C. Thornburg,  A. Sharathkumar, C. McHugh, C. Laurie, A. Crenshaw, D. Mirel, '''Y. Kim''', C. D. Cropp, A. M. Molloy,
-
 
+
P. N. Kirke, J. E. Bailey-Wilson, A. F. Wilson, J. L. Mills,  J. M. Scott, L. C. Brody, J. Z. Li and D. Ginsburg, “ Linkage Analysis Identifies a Novel Locus for Plasma von Willebrand
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* 2001 - 2003 MPH in Biostatistics and Epidemiology, School of Public Health, Seoul National University, Seoul, Korea
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Factor Undetected by Genome Wide Association”, doi:10.1073/pnas.1219885110, '''''PNAS''''', 2012.
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* 2003 – 2008         Ph.D. in Biostatistics and Epidemiology, School of Public Health, Seoul National University, Seoul, Korea
 
 +
C. M. Justice*, G. Yagnik*, '''Y. Kim''', I. Peter, E. W. Jabs, X. Ye, L. Shi, M.L. Cunningham, V. Kimonis, T. Roscioli, S. A. Wall, A. O.M. Wilkie, J. Stoler, J. T. Richtsmeier, Y. Heuze, P. A. Sanchez-Lara, M. F. Buckley, C. M. Druschel, J. L. Mills, M.Caggana, P. A. Romitti, D. M. Kay, C. Senders, P.J. Taub, O. D. Klein, J. Boggan, M. Zwienenberg-Lee, C. Naydenov, J. Kim,  A.F. Wilson, S. A. Boyadijiev, “A genome-wide association study identifies susceptibility loci for nonsyndromic sagittal craniosynostosis near BMP2 and within BBS9”, doi:10.1038/ng.2463 '''''Nature Genetics''''', 44, 1360-1364, 2012.
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== '''Predoctoral Training and Fellowship Appointments''' ==
 
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* 2005 – 2007 :  Predoctoral trainee in Statistical Genetics ([http://www.genome.gov/10000339 Dr. Joan E. Bailey-Wilson]), IDRB/NHGRI/NIH, Maryland, USA
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Y. Kirino, G. Bertsias, Y. Ishigatsubo, N. Mizuki, I. Tugal-Tutkun, E. Seyahi, Y. Ozyazgan, F. S.Sacli, B. Erer, Z. Emrence, A. Cakar, D. Ustek, C. Satorius, A. Ueda, M. Takeno, '''Y. Kim''', M. J. Ombrello, A. Meguro, A. Gul, E.F. Remmers, D.L.Kastner, “A genome-wide association study identifies new susceptibility loci for Behcet’s disease and epistasis between HLA-B*51 and ERAP1”, doi:10.1038/ng.2520'''''Nature Genetics''''', 2012.
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* 2005 – 2006  :  Predoctoral trainee awards by Korea Research Foundation (KRF-2005-213-C00007)
 
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* 2007 – 2008  :  Predoctoral trainee in Genometrics ([http://www.genome.gov/10000710 Dr. Alexander F. Wilson]), IDRB/NHGRI/NIH, Maryland, USA
 
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* 2008 – present :  Postdoctoral fellow in Genometrics ([http://www.genome.gov/10000710 Dr. Alexander F. Wilson]), IDRB/NHGRI/NIH, Maryland, USA
 
 +
N. H. Miller, C. M. Justice, B. Marosy, K. Swindle,''' Y. Kim''', MH. Roy-Gagnon, H. Sung, D. Behneman, K. F. Doheny, E. Pugh, A .F. Wilson “Fine-mapping and family-based association tests of idiopathic scoliosis on 9q31.3-134.3 and 16p12.3-q22.2,” '''''Human Heredity''''', Vol 74, No. 1, 36-44, 2012.
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== '''Ongoing Projects''' ==
 
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* Analyzed data using SAS, R, SIBPAIR, S.A.G.E, SOLAR and Perl script, ''Genotypic Determinants of Aspirin Response in High Risk Families'' with Dr. Lewis C. Becker, School of Medicine, Johns Hopkins University, Baltimore, MD, U.S.A [http://www.jhufamilyheart.com JHU Sibling and Family Heart Study ]
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N. N. Hansel, I. Ruczinski, N. Rafaels, D. D. Sin, D. Daley, A. Malinina, L. Huang, A. Sandford, M. Elliott, T. Murray, '''Y. Kim''', C. Vergara, S. R. Heckbert, B. M. Psaty, G. Li, F. Aminuddin, J. Dupuis, G. O’Connor, M. Boezen, D.S.Postma, J.Smolonska, R. Crystal, T. Toshiko, L. Ferruci, E. Silverman, E. Wan, J. Vestbo, D. Lomas, J. Connett, R. A. Wise, E.R. Neptune, R. Mathias, P.D. Pare, T. H. Beaty, K. C. Barnes “Genome-wide study identifies two loci associated with lung function decline in mild to moderate COPD,” '''''Human Genetics''''', DOI: 10.1007/s00439-012-1219-6, 2012. PMID: 22986903
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* Analyzed data using R, SIBPAIR, S.A.G.E, SOLAR and Perl script, ''Family based association studies vs Population based association studies'', NIH
 
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* Managed and analyzed data using Sib pair, Merlin, and Genehunter, ''Nonparametric Linkage Analysis of Hypocholesterolemic Autism Patients and their families'' with Dr. Elaine Tierney, Kennedy Krieger Institute, Baltimore, MD, U.S.A [http://www.kennedykrieger.org Kennedy Krieger Institute]
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M. J. Emond, T. Louie, J. Emerson, W. Zhao, R. A. Mathias, M. R. Knowles, F. A. Wright, M. J. Rieder, H.K. Tabor, D.A. Nickerson, K.C. Barnes, NHLBI GO Exome Sequencing Project, Lung GO ('''Y. Kim'''), R.L. Gibson & M.J. Bamshad “Exome sequencing of extreme phenotypes identifies DCTN4 as a modifier of chronic Pseudomonas aeruginosa infection in cystic fibrosis,” '''''Nature Genetics''''', Vol 44: 886–889, 2012.  
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== '''Publications''' ==
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S. P. David, A. Hamidovic, G. K. Chen, A.W. Bergen, J. Wessel, J.L. Kasberger, W. M. Brown, S. Petruzella, E. L. Thacker, '''Y. Kim''', M.A. Nalls, G. J. Tranah, Y.J. Sung, AABC, AAPC, CHS, CARe, GeneSTAR, HANDLS, HealthABC, HyperGEN, WHI(SHARe), C.A. Haiman, H.Furberg, “Genome-wide meta-analyses of smoking behaviors in African Americans”, '''''Translational Psychiatry''''', 2:e119; doi:10.1038/tp.2012.41, 2012.
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1. '''Yoonhee Kim''', Woongyang Park and Ho Kim, “An iterative normalization algorithm from cDNA microarray medical data analysis”, Genomics & Informatics, 2004, Vol.2 (2) 94-100.
 
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2. S.H. Lee, H.J. Bae, S.J. Kwon, H. Kim, '''Y.H. Kim''', B.W. Yoon, and J.K. Roh, “Cerebral microbleeds are regionally associated with intra cerebral hemorrhage”, NEUROLOGY, 2004, 62:72-76
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'''Y. Kim'''*, Q. Li*, C.D. Cropp, H. Sung, J. Cai, C.L. Simpson, B.Perry, A.Dasgupta, J.D. Malley, A.F. Wilson, J.E. Bailey-Wilson “Performance of Random Forests and Logic Regression Methods Using Mini-Exome Sequence data,” '''''BMC proceedings''''', Vol 5 (supp 9):S104, 2011. PMID: 22373484 PMCID: PMC3287827
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3. S.H. Lee, J.M. Park, S.J. Kwon, H. Kim, '''Y.H. Kim''', J.K. Roh, and B.W. Yoon, “Left ventricular hypertrophy is associated with cerebral microbleeds in hypertensive patients”, NEUROLOGY,  2004. 63: 16-21.
 
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4. Sung J, Cho SI, Song YM, Lee K, Choi EY, Ha M, Kim J, Kim H, Kim Y, Shin EK, '''Kim YH''', Yoo KY, Park C, Kimm K, “Do we need more twin studies? The Healthy Twin Study, Korea”, Int J Epidemiol. 2006; 35(2):488-90.
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J.E. Bailey-Wilson, J.S. Brennan, R. Culverhouse, '''Y. Kim''', Y. Jiang, J. Jung, Q. Li, C. Scholosberg, L. Wang, Y.E. Yilmaz, H. Zhang, Z. Zhan, “Regression and Data Mining Methods for Analyses of Multiple Rare Variants in GAW17 “ Mini-Exome” data,”  '''''Genetic Epidemiology''''', Vol 35(supp 1):S92-S100, 2011. PMID: 22128066 PMCID: PMC3360949
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5. '''Y. Kim''', B. Doan, P. Duggal, J. E. Bailey-Wilson, “Normalization of microarray expression data using within-pedigree pool and its effect on linkage analysis”, BMC Genetics Proceedings, 2007 I (Suppl 1) S152.
 
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6. '''Y. Kim''', P. Duggal, E.M. Gillanders, H. Kim, J.E. Bailey-Wilson, “Examining the effect of linkage disequilibrium between markers on the Type I error rate and power of nonparametric multipoint linkage analysis of two-generation and multigenerational pedigrees in the presence of missing genotype data”, Genetic Epidemiology, 2008; 32:41-51.
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H. Sung, '''Y. Kim''', J. Cai, C.D. Cropp, C.L. Simpson, Q. Li, B. C Perry,  A.J.M. Sorant, J.E. Bailey-Wilson, A.F. Wilson “A comparison of results from tests of association in unrelated individuals with uncollapsed and collapsed sequence variants using tiled regression,” '''''BMC proceedings''''', Vol 5(supp 9):S15, 2011. PMID: 22373501 PMCID: PMC3287849
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 +
 
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T.L. Assimes, H. Holm, ADVANCE, CATHGEN, GeneSTAR ('''Y. Kim'''), INTERHEART study groups, decode genetics, and T. Quertermous “Lack of association between the Trp719Arg polymorphism in kinesin-like protein 6 and coronary artery disease in 19 case-control studies,” '''''Journal of the American College of Cardiology''''', Vol 56, No 19, 2010. PMID: 20933357 PMCID: PMC3084526
 +
 
 +
 
 +
R.A. Mathias*, '''Y. Kim'''*, H. Sung, R.Y. Yanek, J.E. Hererra-Galeano, I. Ruczinski, A.F. Wilson, N. Faraday, L.C. Becker, D.M. Becker “A Combined genome-wide linkage and association approach to find susceptibility loci for platelet function phenotypes in Caucasian and African American families with coronary artery disease,” '''''BMC Medical Genomics''''', 3:22, 2010. PMID: 20529293 PMCID: PMC2890666
 +
 
 +
 
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'''Y. Kim''', R. Wojciechowski, H. Sung, R.A. Mathias, L. Wang, A.P. Klein, R.K. Lenroot, J. Malley, J.E. Bailey-Wilson, “Evaluation of random forests performance for genome wide association studies in the presence of interaction effects,” '''''BMC Proceedings''''', Vol3 (supp 7) s64, 2009. PMID: 20018058 PMCID: PMC2795965
 +
 
 +
 
 +
'''Y. Kim''', P. Duggal, E.M. Gillanders, H. Kim, J.E. Bailey-Wilson, “Examining the effect of linkage disequilibrium between markers on the Type I error rate and power of nonparametric multipoint linkage analysis of two-generation and multigenerational pedigrees in the presence of missing genotype data,” '''''Genetic Epidemiology'''''; 32:41-51, 2008. PMID: 17685456 PMCID: PMC2216429
 +
 
 +
 
 +
'''Y. Kim''', H. Kim. “Application of Random Forests to Association Studies Using Mitochondrial Single Nucleotide Polymorphisms,” '''''Genomics & Informatics''''' Vol. 5 (4) 168-173, 2007.
 +
 
 +
 
 +
'''Y. Kim''', B. Doan, P. Duggal, J. E. Bailey-Wilson, “Normalization of microarray expression data using within-pedigree pool and its effect on linkage analysis,” '''''BMC Genetics Proceedings''''', I (Supp 1) S152, 2007.
 +
 
 +
 
 +
Sung J, Cho SI, Song YM, Lee K, Choi EY, Ha M, Kim J, Kim H, Kim Y, Shin EK, Kim YH, Yoo KY, Park C, Kimm K, “Do we need more twin studies? The Healthy Twin Study, Korea,” '''''Int J Epidemiology''''', 35(2):488-90, 2006.
 +
 
 +
 
 +
S.H. Lee, J.M. Park, S.J. Kwon, H. Kim, '''Y.H. Kim''', J.K. Roh, and B.W. Yoon, “Left ventricular hypertrophy is associated with cerebral microbleeds in hypertensive patients,” '''''Neurology''''', 63: 16-21, 2004.
 +
 
 +
 
 +
S.H. Lee, H.J. Bae, S.J. Kwon, H. Kim, '''Y.H. Kim''', B.W. Yoon, and J.K. Roh, “Cerebral microbleeds are regionally associated with intra cerebral hemorrhage,”  '''''Neurology''''', 62:72-76, 2004.
 +
 
 +
 
 +
'''Y. Kim''', W. Park, H. Kim, “An iterative normalization algorithm from cDNA microarray medical data analysis,” '''''Genomics & Informatics''''', Vol.2 (2) 94-100, 2004.

Revision as of 23:12, 4 February 2013

Contents

Yoonhee Kim, M.P.H, Ph.D.

RESEARCH INTEREST

Statistical Genetics, Genetic Epidemiology

Next Generation Sequencing data analysis, GenexGene Interaction analysis using Machine Learning Methods (Random Forests)


EDUCATION

2008 Ph.D. Seoul National University, School of Public Health

2003 M.P.H Seoul National University, School of Public Health

2001 B.S. Ewha Womans Univerisity

PUBLICATION

(* co-first author)


K. C. Desch, A. B. Ozel, D. Siemieniak, Y. Kalish, C. Thornburg, A. Sharathkumar, C. McHugh, C. Laurie, A. Crenshaw, D. Mirel, Y. Kim, C. D. Cropp, A. M. Molloy, P. N. Kirke, J. E. Bailey-Wilson, A. F. Wilson, J. L. Mills, J. M. Scott, L. C. Brody, J. Z. Li and D. Ginsburg, “ Linkage Analysis Identifies a Novel Locus for Plasma von Willebrand Factor Undetected by Genome Wide Association”, doi:10.1073/pnas.1219885110, PNAS, 2012.


C. M. Justice*, G. Yagnik*, Y. Kim, I. Peter, E. W. Jabs, X. Ye, L. Shi, M.L. Cunningham, V. Kimonis, T. Roscioli, S. A. Wall, A. O.M. Wilkie, J. Stoler, J. T. Richtsmeier, Y. Heuze, P. A. Sanchez-Lara, M. F. Buckley, C. M. Druschel, J. L. Mills, M.Caggana, P. A. Romitti, D. M. Kay, C. Senders, P.J. Taub, O. D. Klein, J. Boggan, M. Zwienenberg-Lee, C. Naydenov, J. Kim, A.F. Wilson, S. A. Boyadijiev, “A genome-wide association study identifies susceptibility loci for nonsyndromic sagittal craniosynostosis near BMP2 and within BBS9”, doi:10.1038/ng.2463 Nature Genetics, 44, 1360-1364, 2012.


Y. Kirino, G. Bertsias, Y. Ishigatsubo, N. Mizuki, I. Tugal-Tutkun, E. Seyahi, Y. Ozyazgan, F. S.Sacli, B. Erer, Z. Emrence, A. Cakar, D. Ustek, C. Satorius, A. Ueda, M. Takeno, Y. Kim, M. J. Ombrello, A. Meguro, A. Gul, E.F. Remmers, D.L.Kastner, “A genome-wide association study identifies new susceptibility loci for Behcet’s disease and epistasis between HLA-B*51 and ERAP1”, doi:10.1038/ng.2520Nature Genetics, 2012.


N. H. Miller, C. M. Justice, B. Marosy, K. Swindle, Y. Kim, MH. Roy-Gagnon, H. Sung, D. Behneman, K. F. Doheny, E. Pugh, A .F. Wilson “Fine-mapping and family-based association tests of idiopathic scoliosis on 9q31.3-134.3 and 16p12.3-q22.2,” Human Heredity, Vol 74, No. 1, 36-44, 2012.


N. N. Hansel, I. Ruczinski, N. Rafaels, D. D. Sin, D. Daley, A. Malinina, L. Huang, A. Sandford, M. Elliott, T. Murray, Y. Kim, C. Vergara, S. R. Heckbert, B. M. Psaty, G. Li, F. Aminuddin, J. Dupuis, G. O’Connor, M. Boezen, D.S.Postma, J.Smolonska, R. Crystal, T. Toshiko, L. Ferruci, E. Silverman, E. Wan, J. Vestbo, D. Lomas, J. Connett, R. A. Wise, E.R. Neptune, R. Mathias, P.D. Pare, T. H. Beaty, K. C. Barnes “Genome-wide study identifies two loci associated with lung function decline in mild to moderate COPD,” Human Genetics, DOI: 10.1007/s00439-012-1219-6, 2012. PMID: 22986903


M. J. Emond, T. Louie, J. Emerson, W. Zhao, R. A. Mathias, M. R. Knowles, F. A. Wright, M. J. Rieder, H.K. Tabor, D.A. Nickerson, K.C. Barnes, NHLBI GO Exome Sequencing Project, Lung GO (Y. Kim), R.L. Gibson & M.J. Bamshad “Exome sequencing of extreme phenotypes identifies DCTN4 as a modifier of chronic Pseudomonas aeruginosa infection in cystic fibrosis,” Nature Genetics, Vol 44: 886–889, 2012.


S. P. David, A. Hamidovic, G. K. Chen, A.W. Bergen, J. Wessel, J.L. Kasberger, W. M. Brown, S. Petruzella, E. L. Thacker, Y. Kim, M.A. Nalls, G. J. Tranah, Y.J. Sung, AABC, AAPC, CHS, CARe, GeneSTAR, HANDLS, HealthABC, HyperGEN, WHI(SHARe), C.A. Haiman, H.Furberg, “Genome-wide meta-analyses of smoking behaviors in African Americans”, Translational Psychiatry, 2:e119; doi:10.1038/tp.2012.41, 2012.


Y. Kim*, Q. Li*, C.D. Cropp, H. Sung, J. Cai, C.L. Simpson, B.Perry, A.Dasgupta, J.D. Malley, A.F. Wilson, J.E. Bailey-Wilson “Performance of Random Forests and Logic Regression Methods Using Mini-Exome Sequence data,” BMC proceedings, Vol 5 (supp 9):S104, 2011. PMID: 22373484 PMCID: PMC3287827


J.E. Bailey-Wilson, J.S. Brennan, R. Culverhouse, Y. Kim, Y. Jiang, J. Jung, Q. Li, C. Scholosberg, L. Wang, Y.E. Yilmaz, H. Zhang, Z. Zhan, “Regression and Data Mining Methods for Analyses of Multiple Rare Variants in GAW17 “ Mini-Exome” data,” Genetic Epidemiology, Vol 35(supp 1):S92-S100, 2011. PMID: 22128066 PMCID: PMC3360949


H. Sung, Y. Kim, J. Cai, C.D. Cropp, C.L. Simpson, Q. Li, B. C Perry, A.J.M. Sorant, J.E. Bailey-Wilson, A.F. Wilson “A comparison of results from tests of association in unrelated individuals with uncollapsed and collapsed sequence variants using tiled regression,” BMC proceedings, Vol 5(supp 9):S15, 2011. PMID: 22373501 PMCID: PMC3287849


T.L. Assimes, H. Holm, ADVANCE, CATHGEN, GeneSTAR (Y. Kim), INTERHEART study groups, decode genetics, and T. Quertermous “Lack of association between the Trp719Arg polymorphism in kinesin-like protein 6 and coronary artery disease in 19 case-control studies,” Journal of the American College of Cardiology, Vol 56, No 19, 2010. PMID: 20933357 PMCID: PMC3084526


R.A. Mathias*, Y. Kim*, H. Sung, R.Y. Yanek, J.E. Hererra-Galeano, I. Ruczinski, A.F. Wilson, N. Faraday, L.C. Becker, D.M. Becker “A Combined genome-wide linkage and association approach to find susceptibility loci for platelet function phenotypes in Caucasian and African American families with coronary artery disease,” BMC Medical Genomics, 3:22, 2010. PMID: 20529293 PMCID: PMC2890666


Y. Kim, R. Wojciechowski, H. Sung, R.A. Mathias, L. Wang, A.P. Klein, R.K. Lenroot, J. Malley, J.E. Bailey-Wilson, “Evaluation of random forests performance for genome wide association studies in the presence of interaction effects,” BMC Proceedings, Vol3 (supp 7) s64, 2009. PMID: 20018058 PMCID: PMC2795965


Y. Kim, P. Duggal, E.M. Gillanders, H. Kim, J.E. Bailey-Wilson, “Examining the effect of linkage disequilibrium between markers on the Type I error rate and power of nonparametric multipoint linkage analysis of two-generation and multigenerational pedigrees in the presence of missing genotype data,” Genetic Epidemiology; 32:41-51, 2008. PMID: 17685456 PMCID: PMC2216429


Y. Kim, H. Kim. “Application of Random Forests to Association Studies Using Mitochondrial Single Nucleotide Polymorphisms,” Genomics & Informatics Vol. 5 (4) 168-173, 2007.


Y. Kim, B. Doan, P. Duggal, J. E. Bailey-Wilson, “Normalization of microarray expression data using within-pedigree pool and its effect on linkage analysis,” BMC Genetics Proceedings, I (Supp 1) S152, 2007.


Sung J, Cho SI, Song YM, Lee K, Choi EY, Ha M, Kim J, Kim H, Kim Y, Shin EK, Kim YH, Yoo KY, Park C, Kimm K, “Do we need more twin studies? The Healthy Twin Study, Korea,” Int J Epidemiology, 35(2):488-90, 2006.


S.H. Lee, J.M. Park, S.J. Kwon, H. Kim, Y.H. Kim, J.K. Roh, and B.W. Yoon, “Left ventricular hypertrophy is associated with cerebral microbleeds in hypertensive patients,” Neurology, 63: 16-21, 2004.


S.H. Lee, H.J. Bae, S.J. Kwon, H. Kim, Y.H. Kim, B.W. Yoon, and J.K. Roh, “Cerebral microbleeds are regionally associated with intra cerebral hemorrhage,” Neurology, 62:72-76, 2004.


Y. Kim, W. Park, H. Kim, “An iterative normalization algorithm from cDNA microarray medical data analysis,” Genomics & Informatics, Vol.2 (2) 94-100, 2004.

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