Brett Boghigian

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[[Pfeifer Lab|Pfeifer Lab OWW Homepage]]
 
[[Image:2009Sumposium2.jpg|thumb|500px|right|Giving a talk at Tufts in the spring of 2009]]
[[Image:2009Sumposium2.jpg|thumb|500px|right|Giving a talk at Tufts in the spring of 2009]]
== Contact Information ==
== Contact Information ==
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Department of Chemical & Biological Engineering<br>Tufts University<br>Science & Technology Center<br>4 Colby Street<br>Medford, MA 02155<br>Lab/Desk: (SciTech 286) 617.627.2685<br>Fax: 617.627.3991<br>E-mail: brett [dot] boghigian [at] tufts [dot] edu
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In April 2011, Brett joined the founding team as the third scientific hire of [http://www.pronutria.com/ Pronutria] (formerly known as Essentient, Inc.). Pronutria is a [http://www.flagshipventures.com/venturelabs Flagship VentureLabs™] company, founded to transform global food security and nutrition, fueling human potential.
== Education ==
== Education ==
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* 2007-present Ph.D. Chemical Engineering, Tufts University
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* 2010 - Ph.D. Chemical Engineering, Tufts University
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* 2003-2007 B.S. Chemical Engineering (philosophy minor), Tufts University
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**Thesis: "Multi-scale engineering and modeling of heterologous natural product biosynthesis in ''Escherichia coli''" (384pp)
 +
**Adviser: [http://www.cbe.buffalo.edu/people/full_time/b_pfeifer.php Professor Blaine A. Pfeifer]
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* 2007 - B.S. Chemical Engineering (Minor in Philosophy), Tufts University
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==Research Interests==
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==Scientific Expertise==
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My research and academic interests are in: metabolic engineering, natural products, molecular biology, computational systems biology, analytical proteomics and metabolomics, bioreactor engineering, and protein purification. Although they are not topics of my research, I am interested in the philosophy of molecular biology and evolution, as well as alternative fuel technology.
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Metabolic engineering and strain development, upstream and downstream bioprocess development, photosynthetic organisms, computational systems biology, analytical chemistry, natural products, synthetic biology
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==Publications==
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==Peer-Reviewed Publications==
(* indicates co-first author. <sup>†</sup> indicates undergraduate author)
(* indicates co-first author. <sup>†</sup> indicates undergraduate author)
-
*'''Boghigian BA''', Zhang H, Pfeifer BA. Multi-scale engineering of heterologous polyketide production in ''Escherichia coli'' reveals complex pathway interactions. 2010. In preparation.
+
*'''Boghigian BA''', Armando J<sup>†</sup>, Salas DF<sup>†</sup>, Pfeifer BA. Computational identification of gene over-expression targets for metabolic engineering. ''Appl Microbiol Biotechnol''. 2012 Mar;93(5):2063-73. ([http://www.springerlink.com/content/139515226x50p4l8/ Link])
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*Meng H*, '''Boghigian BA'''*, Wang Y, Pfeifer BA, Zhang S, Wang X. ''In silico'' analysis and comparison of the two terpenoid precursor supply pathways. 2010. In preparation.
+
*'''Boghigian BA''', Salas DF<sup>†</sup>, Ajikumar PK, Stephanopoulos G, Pfeifer BA. Analysis of heterologous taxadiene production in K- and B-derived ''Escherichia coli''. ''Appl Microbiol Biotechnol''. 2012 Feb;93(4):1651-61. ([http://www.springerlink.com/content/et466722130hk103/ Link])
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*'''Boghigian BA'''*, Wang Y*, Salas DF<sup>†</sup>, Ajikumar PK, Stephanopoulos G, Pfeifer BA. Genetic and process strategies for improved heterologous taxadiene production in K- and B-derived ''Escherichia coli''. 2010. In preparation.
+
*Armando J<sup>†</sup>, '''Boghigian BA''', Pfeifer BA. LC-MS/MS quantification of short-chain acyl-CoA's in ''Escherichia coli'' demonstrates versatile propionyl-CoA synthetase substrate specificity. ''Lett Appl Microbiol''. 2012 Feb;54(2):140-8. ([http://onlinelibrary.wiley.com/doi/10.1111/j.1472-765X.2011.03184.x/abstract Link])
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*Wu J, '''Boghigian BA''', Myint M<sup>†</sup>, Zhang H, Zhang S, Pfeifer BA. Construction and performance of heterologous polyketide producing K-12- and B-derived ''Escherichia coli''. ''Lett Appl Microbiol''. 2010. In press. ([http://www.ncbi.nlm.nih.gov/pubmed/20565574 PubMed])
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*'''Boghigian BA'''*, Myint M*<sup>†</sup>, Wu J, Pfeifer BA. Simultaneous production and partitioning of heterologous polyketide and isoprenoid natural products in an ''Escherichia coli'' two-phase bioprocess. ''J Ind Microbiol Biotechnol''. 2011 Nov;38(11):1809-20. ([http://www.springerlink.com/content/3u171954p2h43786/ Link])
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*'''Boghigian BA''', Shi H, Lee K, Pfeifer BA. Utilizing elementary mode analysis, pathway thermodynamics, and a genetic algorithm for metabolic flux determination and optimal metabolic network design. ''BMC Syst Biol''. 2010 Apr 23;4(1):49. ([http://www.ncbi.nlm.nih.gov/pubmed/20416071 PubMed])
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*'''Boghigian BA''', Zhang H, Pfeifer BA. Multi-factorial engineering of heterologous polyketide production in ''Escherichia coli'' reveals complex pathway interactions. ''Biotechnol Bioeng''. 2011 Jun;108(6):1360-71. ([http://onlinelibrary.wiley.com/doi/10.1002/bit.23069/abstract;jsessionid=41BBB7049A007C86746D07C6D4DE59E5.d02t03 Link])
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*'''Boghigian BA''', Seth G, Kiss R, Pfeifer BA. Metabolic flux analysis and pharmaceutical production. ''Metab Eng''. 2010 Mar;12(2):81-95. ([http://www.ncbi.nlm.nih.gov/pubmed/19861167 PubMed])
+
*Zhang H, '''Boghigian BA''', Armando J<sup>†</sup>, Pfeifer BA. Methods and options for the heterologous production of complex natural products. ''Nat Prod Rep''. 2011 Jan 17;28(1):125-51. ([http://pubs.rsc.org/en/Content/ArticleLanding/2011/NP/c0np00037j Link])
 +
*Wu J, '''Boghigian BA''', Myint M<sup>†</sup>, Zhang H, Zhang S, Pfeifer BA. Construction and performance of heterologous polyketide producing K-12- and B-derived ''Escherichia coli''. ''Lett Appl Microbiol''. 2010 Aug;51(2):196-204. ([http://www.ncbi.nlm.nih.gov/pubmed/20565574 PubMed])
 +
*'''Boghigian BA''', Shi H, Lee K, Pfeifer BA. Utilizing elementary mode analysis, pathway thermodynamics, and a genetic algorithm for metabolic flux determination and optimal metabolic network design. ''BMC Syst Biol''. 2010 Apr 23;4(1):49. ([http://www.ncbi.nlm.nih.gov/pubmed/20416071 PubMed]) '''"Highly Accessed" status'''
 +
*'''Boghigian BA''', Seth G, Kiss R, Pfeifer BA. Metabolic flux analysis and pharmaceutical production. ''Metab Eng''. 2010 Mar;12(2):81-95. ([http://www.ncbi.nlm.nih.gov/pubmed/19861167 PubMed]) '''"Most Downloaded" status'''
*Zhang H, '''Boghigian BA''', Pfeifer BA. Investigating the role of native propionyl-CoA and methylmalonyl-CoA metabolism on heterologous polyketide production in ''Escherichia coli''. ''Biotechnol Bioeng''. 2010 Feb 15;105(3):567-73. ([http://www.ncbi.nlm.nih.gov/pubmed/19806677 PubMed])
*Zhang H, '''Boghigian BA''', Pfeifer BA. Investigating the role of native propionyl-CoA and methylmalonyl-CoA metabolism on heterologous polyketide production in ''Escherichia coli''. ''Biotechnol Bioeng''. 2010 Feb 15;105(3):567-73. ([http://www.ncbi.nlm.nih.gov/pubmed/19806677 PubMed])
*'''Boghigian BA''', Lee K, Pfeifer BA. Computational analysis of phenotypic space in heterologous polyketide biosynthesis – applications to ''Escherichia coli'', ''Bacillus subtilis'', and ''Saccharomyces cerevisiae''. ''J Theor Biol''. 2010 Jan 21;262(2):197-207. ([http://www.ncbi.nlm.nih.gov/pubmed/19833139 PubMed])
*'''Boghigian BA''', Lee K, Pfeifer BA. Computational analysis of phenotypic space in heterologous polyketide biosynthesis – applications to ''Escherichia coli'', ''Bacillus subtilis'', and ''Saccharomyces cerevisiae''. ''J Theor Biol''. 2010 Jan 21;262(2):197-207. ([http://www.ncbi.nlm.nih.gov/pubmed/19833139 PubMed])
Line 25: Line 29:
*Wang Y*, '''Boghigian BA'''*<sup>†</sup>, Pfeifer BA. Improving heterologous polyketide production in ''Escherichia coli'' by overexpression of an ''S''-adenosylmethionine synthetase gene. ''Appl Microbiol Biotechnol''. 2007 Nov;77(2):367-73. ([http://www.ncbi.nlm.nih.gov/pubmed/18488149 PubMed])
*Wang Y*, '''Boghigian BA'''*<sup>†</sup>, Pfeifer BA. Improving heterologous polyketide production in ''Escherichia coli'' by overexpression of an ''S''-adenosylmethionine synthetase gene. ''Appl Microbiol Biotechnol''. 2007 Nov;77(2):367-73. ([http://www.ncbi.nlm.nih.gov/pubmed/18488149 PubMed])
*Scrivener E, '''Boghigian BA'''<sup>†</sup>, Golenko E, Bogdanova A, Jackson P, Mikulskis A, Denoyer E, Courtney P, Lopez MF, Patton WF. Performance validation of an improved Xenon-arc lamp-based CCD camera system for multispectral imaging in proteomics. ''Proteomics''. 2005 Nov;5(17):4354-66. ([http://www.ncbi.nlm.nih.gov/pubmed/16206330 PubMed])
*Scrivener E, '''Boghigian BA'''<sup>†</sup>, Golenko E, Bogdanova A, Jackson P, Mikulskis A, Denoyer E, Courtney P, Lopez MF, Patton WF. Performance validation of an improved Xenon-arc lamp-based CCD camera system for multispectral imaging in proteomics. ''Proteomics''. 2005 Nov;5(17):4354-66. ([http://www.ncbi.nlm.nih.gov/pubmed/16206330 PubMed])
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*Stehmann C, '''Boghigian BA'''<sup>†</sup>, Golenko E, Scrivener E, Patton WF, Lopez MF. A Xenon-arc lamp-based charge-coupled device (CCD) camera system for multispectral imaging in proteomics. ''Mol Cell Proteomics''. 2004 Oct;3(10):S301.
 
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==Recognition==
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==Conference Presentations==
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*2009 – ''Outstanding Graduate Contributor to Engineering Education Award'', Tufts University School of Engineering
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*'''Boghigian BA''', Pfeifer BA. Multi-scale engineering of heterologous polyketide and isoprenoid natural products in ''Escherichia coli''. SIM Annual Meeting (San Francisco, CA). 2010.
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*2008 – ''Best Teaching Assistant Award'', Tufts University Department of Chemical & Biological Engineering
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*'''Boghigian BA''', Wang Y, Salas D, Stephanopoulos G, Pfeifer BA. Multi-scale engineering of a Taxol<sup>®</sup> precursor in ''Escherichia coli''. AIChE Annual Meeting (Nashville, TN). 2009.
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*2007 – ''Best Presentation Award'', Tufts University Undergraduate Research Symposium
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*'''Boghigian BA''', Wang Y, Pistorino M, Pfeifer BA. Multiple approaches to improving heterologous polyketide production from ''E. coli''. Metabolic Engineering VII (Puerto Vallarta, Mexico). 2008.
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*2006 – ''Outstanding Chemical Engineering Student at Tufts University'', Boston Section of the American Institute of Chemical Engineers
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*'''Boghigian BA''', Wang Y, Lee K, Pfeifer BA. Improving heterologous polyketide production in ''Escherichia coli'' through signal pathway engineering and metabolic modeling. Boston Bacteriology Meeting (Cambridge, MA). 2008.
 +
*'''Boghigian BA'''<sup>†</sup>, Wang Y, Pfeifer BA. A closer look at ''E. coli''-derived 6-deoxyerythronolide B biosynthesis. AIChE Annual Meeting (San Francisco, CA). 2006.
 +
*Wang Y, '''Boghigian BA'''<sup>†</sup>, Shi G, Zhang H, Lavoie JR, Pfeifer BA. Enhancing polyketide production in ''E. coli'' by the accumulating of intracellular ''S''-adenosylmethionine. Boston Bacterial Meeting (Cambridge, MA). 2006.
 +
*Stehmann C, '''Boghigian BA'''<sup>†</sup>, Golenko E, Scrivener E, Patton WF, Lopez MF. A xenon-arc lamp-based charge-coupled device (CCD) camera system for multispectral imaging in proteomics. ''Mol Cell Proteomics''. 2004 Oct;3(10):S301. HUPO 3rd Annual World Congress (Beijing, China). 2004.
== Work Experience ==
== Work Experience ==
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* May05–present – [http://ase.tufts.edu/chemical/facPfeifer.htm Pfeifer Lab], Chemical & Biological Engineering, Tufts University (Medford, MA)
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* 2011.04-current – [http://www.pronutria.com/ Pronutria] (Cambridge, MA)
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* May07–Aug07 – [http://www.wyeth.com/ Wyeth BioPharma], Purification Process Development (Andover, MA)
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* 2007.09-2011.04 – Pfeifer Lab, Chemical & Biological Engineering, Tufts University (Medford, MA)
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* Sep04–May05 – [http://ase.tufts.edu/biomedical/faculty-staff/kaplan.asp Kaplan Lab], Biomedical Engineering, Tufts University (Medford, MA)
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* 2007.05-2007.09 – [http://www.wyeth.com/ Wyeth BioPharma (currently Pfizer)], Purification Process Development (Andover, MA)
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* Jun04–Sep04 – [http://www.perkinelmer.com/ PerkinElmer Life & Analytical Sciences], Biochemistry (Boston, MA)
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* 2005.05-2007.05 – Pfeifer Lab, Chemical & Biological Engineering, Tufts University (Medford, MA)
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* May04–Aug04 – [http://www.noelleindustries.com/ Noelle Industries], Process Manufacturing (Billerica, MA)
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* 2004.09-2005.05 – [http://ase.tufts.edu/biomedical/faculty-staff/kaplan.asp Kaplan Lab], Biomedical Engineering, Tufts University (Medford, MA)
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* A lot more you don't care about
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* 2004.04-2004.09 – [http://www.perkinelmer.com/ PerkinElmer Life & Analytical Sciences], Biochemistry (Boston, MA)
== Teaching Experience ==
== Teaching Experience ==
(all at Tufts University)
(all at Tufts University)
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*Spring 2009 – ''CHBE24B – Senior Projects Laboratory'', Teaching Assistant for [http://engineering.tufts.edu/chbe/people/vinson/index.asp Prof. David R. Vinson]
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*Spring 2009 – ''CHBE24B – Senior Projects Laboratory'', Teaching Assistant for Prof. David R. Vinson
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*Fall 2008 – ''CHBE24A – Senior Projects Laboratory'', Teaching Assistant for [http://engineering.tufts.edu/chbe/people/vinson/index.asp Prof. David R. Vinson]
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*Fall 2008 – ''CHBE24A – Senior Projects Laboratory'', Teaching Assistant for Prof. David R. Vinson
*Spring 2008 – ''CHBE168 – Biotechnology Process Projects Laboratory'', Teaching Assistant for [http://engineering.tufts.edu/chbe/people/yi/index.asp Prof. Hyunmin Yi]
*Spring 2008 – ''CHBE168 – Biotechnology Process Projects Laboratory'', Teaching Assistant for [http://engineering.tufts.edu/chbe/people/yi/index.asp Prof. Hyunmin Yi]
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*Spring 2008 – ''CHBE24B – Senior Projects Laboratory'', Teaching Assistant for [http://engineering.tufts.edu/chbe/people/pfeifer/index.asp Prof. Blaine A. Pfeifer]
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*Spring 2008 – ''CHBE24B – Senior Projects Laboratory'', Teaching Assistant for [http://www.cbe.buffalo.edu/people/full_time/b_pfeifer.php Prof. Blaine A. Pfeifer]
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*Fall 2007 – ''CHBE10 – Thermodynamics & Process Calculations I'', Guest Lecturer for [http://engineering.tufts.edu/chbe/people/pfeifer/index.asp Prof. Blaine A. Pfeifer]
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*Fall 2007 – ''CHBE10 – Thermodynamics & Process Calculations I'', Guest Lecturer for [http://www.cbe.buffalo.edu/people/full_time/b_pfeifer.php Prof. Blaine A. Pfeifer]
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*Fall 2007 – ''CHBE24A − Senior Projects Laboratory'', Teaching Assistant for [http://engineering.tufts.edu/chbe/people/pfeifer/index.asp Prof. Blaine A. Pfeifer]
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*Fall 2007 – ''CHBE24A − Senior Projects Laboratory'', Teaching Assistant for [http://www.cbe.buffalo.edu/people/full_time/b_pfeifer.php Prof. Blaine A. Pfeifer]
*Fall 2006 – ''EN3 – Introduction to Biotechnology Engineering'', Guest Lecturer for [http://engineering.tufts.edu/chbe/people/kaplan/index.asp Prof. David L. Kaplan]
*Fall 2006 – ''EN3 – Introduction to Biotechnology Engineering'', Guest Lecturer for [http://engineering.tufts.edu/chbe/people/kaplan/index.asp Prof. David L. Kaplan]
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== Personal ==
 
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I was born in Cambridge, MA and grew up in a suburb of Boston: Bedford, MA and attended Bedford High School. I graduated with a B.S. in chemical engineering and a minor in philosophy from Tufts University in May of 2007. After a summer working in purification process development at Wyeth BioPharma (now [http://www.pfizer.com/home/ Pfizer]), I started the M.S. program in chemical engineering in our department in the fall of 2007. After a short stint in that program, I entered the Ph.D. program in chemical engineering. In my free time, I enjoy hanging out with my friends, watching movies (from [http://en.wikipedia.org/wiki/Kubrick Kubrick] and [http://en.wikipedia.org/wiki/Francis_Ford_Coppola Coppola] to [http://en.wikipedia.org/wiki/Ingmar_Bergman Bergman] and [http://en.wikipedia.org/wiki/Fellini Fellini]), watching Boston sports ([http://www.patriots.com/ Pats], [http://boston.redsox.mlb.com/NASApp/mlb/index.jsp?c_id=bos Sox], [http://www.nba.com/celtics/ C's], but not really the [http://bruins.nhl.com/index.html B's]), listening to music (from [http://en.wikipedia.org/wiki/Lil_wayne Lil' Wayne] to [http://en.wikipedia.org/wiki/Led_Zeppelin Led Zeppelin] to [http://en.wikipedia.org/wiki/Johnny_cash Johnny Cash]), and playing sports (golf, tennis, basketball, and baseball).
 
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== Links ==
 
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===Press===
 
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* [http://www.tuftsdaily.com/media/storage/paper856/news/2006/03/13/News/Showcasing.Research.From.squishies.To.Snails-1684694.shtml?norewrite200604221924&sourcedomain=www.tuftsdaily.com Article/Picture in the Tufts Daily (3/13/06) - 2006 Undergraduate Research Symposium]
 
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* [http://engineering.tufts.edu/chbe/people/pfeifer/personnelBoghigian.asp On the CHBE Department website]
 
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===Labs of Interest===
 
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* [http://stephanopoulos.openwetware.org/ Gregory Stephanopoulos] (MIT)
 
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* [http://keaslinglab.lbl.gov/wiki/index.php/Main_Page Jay Kesling] (UC Berkeley)
 
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* [http://gcrg.ucsd.edu/Researchers/Palsson Bernhard Palsson] (UC San Diego)
 
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* [http://www.seas.ucla.edu/~liaoj/ James Liao] (UC Los Angeles)
 
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* [http://www.seas.ucla.edu/~yitang/index.htm Yi Tang] (UC Los Angeles)
 
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* [http://www.stanford.edu/group/khosla/ Chaitan Khosla] (Stanford)
 
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* [http://arep.med.harvard.edu/ George Church] (Harvard)
 
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* [http://walsh.med.harvard.edu/ Christopher Walsh] (Harvard)
 
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* [http://maranas.che.psu.edu/ Costas Maranas] (Penn State)
 
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[[Pfeifer Lab|Pfeifer Lab OWW Homepage]]
 

Current revision

Giving a talk at Tufts in the spring of 2009
Giving a talk at Tufts in the spring of 2009

Contents

Contact Information

In April 2011, Brett joined the founding team as the third scientific hire of Pronutria (formerly known as Essentient, Inc.). Pronutria is a Flagship VentureLabs™ company, founded to transform global food security and nutrition, fueling human potential.

Education

  • 2010 - Ph.D. Chemical Engineering, Tufts University
    • Thesis: "Multi-scale engineering and modeling of heterologous natural product biosynthesis in Escherichia coli" (384pp)
    • Adviser: Professor Blaine A. Pfeifer
  • 2007 - B.S. Chemical Engineering (Minor in Philosophy), Tufts University

Scientific Expertise

Metabolic engineering and strain development, upstream and downstream bioprocess development, photosynthetic organisms, computational systems biology, analytical chemistry, natural products, synthetic biology

Peer-Reviewed Publications

(* indicates co-first author. indicates undergraduate author)

  • Boghigian BA, Armando J, Salas DF, Pfeifer BA. Computational identification of gene over-expression targets for metabolic engineering. Appl Microbiol Biotechnol. 2012 Mar;93(5):2063-73. (Link)
  • Boghigian BA, Salas DF, Ajikumar PK, Stephanopoulos G, Pfeifer BA. Analysis of heterologous taxadiene production in K- and B-derived Escherichia coli. Appl Microbiol Biotechnol. 2012 Feb;93(4):1651-61. (Link)
  • Armando J, Boghigian BA, Pfeifer BA. LC-MS/MS quantification of short-chain acyl-CoA's in Escherichia coli demonstrates versatile propionyl-CoA synthetase substrate specificity. Lett Appl Microbiol. 2012 Feb;54(2):140-8. (Link)
  • Boghigian BA*, Myint M*, Wu J, Pfeifer BA. Simultaneous production and partitioning of heterologous polyketide and isoprenoid natural products in an Escherichia coli two-phase bioprocess. J Ind Microbiol Biotechnol. 2011 Nov;38(11):1809-20. (Link)
  • Boghigian BA, Zhang H, Pfeifer BA. Multi-factorial engineering of heterologous polyketide production in Escherichia coli reveals complex pathway interactions. Biotechnol Bioeng. 2011 Jun;108(6):1360-71. (Link)
  • Zhang H, Boghigian BA, Armando J, Pfeifer BA. Methods and options for the heterologous production of complex natural products. Nat Prod Rep. 2011 Jan 17;28(1):125-51. (Link)
  • Wu J, Boghigian BA, Myint M, Zhang H, Zhang S, Pfeifer BA. Construction and performance of heterologous polyketide producing K-12- and B-derived Escherichia coli. Lett Appl Microbiol. 2010 Aug;51(2):196-204. (PubMed)
  • Boghigian BA, Shi H, Lee K, Pfeifer BA. Utilizing elementary mode analysis, pathway thermodynamics, and a genetic algorithm for metabolic flux determination and optimal metabolic network design. BMC Syst Biol. 2010 Apr 23;4(1):49. (PubMed) "Highly Accessed" status
  • Boghigian BA, Seth G, Kiss R, Pfeifer BA. Metabolic flux analysis and pharmaceutical production. Metab Eng. 2010 Mar;12(2):81-95. (PubMed) "Most Downloaded" status
  • Zhang H, Boghigian BA, Pfeifer BA. Investigating the role of native propionyl-CoA and methylmalonyl-CoA metabolism on heterologous polyketide production in Escherichia coli. Biotechnol Bioeng. 2010 Feb 15;105(3):567-73. (PubMed)
  • Boghigian BA, Lee K, Pfeifer BA. Computational analysis of phenotypic space in heterologous polyketide biosynthesis – applications to Escherichia coli, Bacillus subtilis, and Saccharomyces cerevisiae. J Theor Biol. 2010 Jan 21;262(2):197-207. (PubMed)
  • Zhang H, Wang Y, Boghigian BA, Pfeifer BA. Probing the heterologous metabolism supporting 6-deoxyerythronolide B biosynthesis in E. coli. Microbial Biotechnol. 2009 May;2(3):390-4. (Link)
  • Boghigian BA, Pfeifer BA. Current status, strategies, and potential for the metabolic engineering of heterologous polyketides in Escherichia coli. Biotechnol Lett. 2008 Aug;30(8):1323-30. Review. (PubMed)
  • Wang Y*, Boghigian BA*, Pfeifer BA. Improving heterologous polyketide production in Escherichia coli by overexpression of an S-adenosylmethionine synthetase gene. Appl Microbiol Biotechnol. 2007 Nov;77(2):367-73. (PubMed)
  • Scrivener E, Boghigian BA, Golenko E, Bogdanova A, Jackson P, Mikulskis A, Denoyer E, Courtney P, Lopez MF, Patton WF. Performance validation of an improved Xenon-arc lamp-based CCD camera system for multispectral imaging in proteomics. Proteomics. 2005 Nov;5(17):4354-66. (PubMed)

Conference Presentations

  • Boghigian BA, Pfeifer BA. Multi-scale engineering of heterologous polyketide and isoprenoid natural products in Escherichia coli. SIM Annual Meeting (San Francisco, CA). 2010.
  • Boghigian BA, Wang Y, Salas D, Stephanopoulos G, Pfeifer BA. Multi-scale engineering of a Taxol® precursor in Escherichia coli. AIChE Annual Meeting (Nashville, TN). 2009.
  • Boghigian BA, Wang Y, Pistorino M, Pfeifer BA. Multiple approaches to improving heterologous polyketide production from E. coli. Metabolic Engineering VII (Puerto Vallarta, Mexico). 2008.
  • Boghigian BA, Wang Y, Lee K, Pfeifer BA. Improving heterologous polyketide production in Escherichia coli through signal pathway engineering and metabolic modeling. Boston Bacteriology Meeting (Cambridge, MA). 2008.
  • Boghigian BA, Wang Y, Pfeifer BA. A closer look at E. coli-derived 6-deoxyerythronolide B biosynthesis. AIChE Annual Meeting (San Francisco, CA). 2006.
  • Wang Y, Boghigian BA, Shi G, Zhang H, Lavoie JR, Pfeifer BA. Enhancing polyketide production in E. coli by the accumulating of intracellular S-adenosylmethionine. Boston Bacterial Meeting (Cambridge, MA). 2006.
  • Stehmann C, Boghigian BA, Golenko E, Scrivener E, Patton WF, Lopez MF. A xenon-arc lamp-based charge-coupled device (CCD) camera system for multispectral imaging in proteomics. Mol Cell Proteomics. 2004 Oct;3(10):S301. HUPO 3rd Annual World Congress (Beijing, China). 2004.

Work Experience

  • 2011.04-current – Pronutria (Cambridge, MA)
  • 2007.09-2011.04 – Pfeifer Lab, Chemical & Biological Engineering, Tufts University (Medford, MA)
  • 2007.05-2007.09 – Wyeth BioPharma (currently Pfizer), Purification Process Development (Andover, MA)
  • 2005.05-2007.05 – Pfeifer Lab, Chemical & Biological Engineering, Tufts University (Medford, MA)
  • 2004.09-2005.05 – Kaplan Lab, Biomedical Engineering, Tufts University (Medford, MA)
  • 2004.04-2004.09 – PerkinElmer Life & Analytical Sciences, Biochemistry (Boston, MA)

Teaching Experience

(all at Tufts University)

  • Spring 2009 – CHBE24B – Senior Projects Laboratory, Teaching Assistant for Prof. David R. Vinson
  • Fall 2008 – CHBE24A – Senior Projects Laboratory, Teaching Assistant for Prof. David R. Vinson
  • Spring 2008 – CHBE168 – Biotechnology Process Projects Laboratory, Teaching Assistant for Prof. Hyunmin Yi
  • Spring 2008 – CHBE24B – Senior Projects Laboratory, Teaching Assistant for Prof. Blaine A. Pfeifer
  • Fall 2007 – CHBE10 – Thermodynamics & Process Calculations I, Guest Lecturer for Prof. Blaine A. Pfeifer
  • Fall 2007 – CHBE24A − Senior Projects Laboratory, Teaching Assistant for Prof. Blaine A. Pfeifer
  • Fall 2006 – EN3 – Introduction to Biotechnology Engineering, Guest Lecturer for Prof. David L. Kaplan
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