CH391L/S13/In vitro Selection of FNAs
Functional nucleic acids (FNAs) are RNA, DNA, or XNA(nucleic acid analogues) that perform an activity such as binding or catalyzing a reaction. FNAs are grouped into three main categories Aptamers, Ribozymes, and Deoxyribozymes that are subdivided into either natural or artificial depending on their origin; the exception being Deoxyribozymes as they have yet to be discovered in a living organism. It was only in the 1980s that the 1st ribozyme was discovered that we started to study FNAs and have allowed for the discovery of new methods, such as the SELEX or "In vitro" selection process that we are expanding their potential both as tools for exploring biology and real world problem solving.
Functional Nucleic Acids
Aptamers and Riboswitches
In vitro Selection of Functional Nucleic Acids