CH391L/S13/Introduction: Difference between revisions
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Types of studies referred to as synthetic biology (and other fields that might also claim them). | Types of studies referred to as synthetic biology (and other fields that might also claim them). | ||
* "The goal of synthetic biology is to extend or modify the behavior of organisms and engineer them to perform new tasks."<cite>Andrianantoandro2006</cite> | |||
* "Synthetic biologists come in two broad classes. One uses unnatural molecules to reproduce emergent behaviours from natural biology, with the goal of creating artificial life. The other seeks interchangeable parts from natural biology to assemble into systems that function unnaturally." <cite>Benner2005</cite> | |||
* Bottom-up assembly of genes, organelles and organisms. | |||
** In contrast to traditional "top-down" genetic approaches that look for mutated versions of existing organisms. | |||
** Ex:Re-factoring and re-writing genomes from scratch. | |||
** Create chemical systems with biological behaviors (e.g., self-replication) | |||
* Application of engineering principles to biology. | |||
** Standardized parts that give predictable outcomes when put together in different combinations. | |||
** Instantiating algorithms and problems from physics and math into biology. | |||
** Ex: circuits, DNA computing, metabolic engineering | |||
== Synthetic Biology Conferences/Sessions == | == Synthetic Biology Conferences/Sessions == | ||
Revision as of 07:06, 14 January 2013
Introduction to Synthetic Biology
Very cool links giving the flavor of synthetic biology:
Timeline of Synthetic Biology
| Year | Event |
|---|---|
| 1972 | First publication on recombinant DNA [1] |
| 2003 | First use of the term "BioBrick" [2] |
| 2004 | First iGEM Jamboree |
What is synthetic biology?
Types of studies referred to as synthetic biology (and other fields that might also claim them).
- "The goal of synthetic biology is to extend or modify the behavior of organisms and engineer them to perform new tasks."[3]
- "Synthetic biologists come in two broad classes. One uses unnatural molecules to reproduce emergent behaviours from natural biology, with the goal of creating artificial life. The other seeks interchangeable parts from natural biology to assemble into systems that function unnaturally." [4]
- Bottom-up assembly of genes, organelles and organisms.
- In contrast to traditional "top-down" genetic approaches that look for mutated versions of existing organisms.
- Ex:Re-factoring and re-writing genomes from scratch.
- Create chemical systems with biological behaviors (e.g., self-replication)
- Application of engineering principles to biology.
- Standardized parts that give predictable outcomes when put together in different combinations.
- Instantiating algorithms and problems from physics and math into biology.
- Ex: circuits, DNA computing, metabolic engineering
Synthetic Biology Conferences/Sessions
References
- Jackson DA, Symons RH, and Berg P. Biochemical method for inserting new genetic information into DNA of Simian Virus 40: circular SV40 DNA molecules containing lambda phage genes and the galactose operon of Escherichia coli. Proc Natl Acad Sci U S A. 1972 Oct;69(10):2904-9. DOI:10.1073/pnas.69.10.2904 |
Biochemical method for inserting new genetic information into DNA of Simian Virus 40: circular SV40 DNA molecules containing lambda phage genes and the galactose operon of Escherichia coli.
-
Idempotent Vector Design for Standard Assembly of Biobricks
