CH391L/S2013/SuggestedTopics

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== Topics ==
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= Topics =
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Us this page to brainstorm or suggest possible topics and ideas
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[[:Category:CH391L_S2013 | Index of All CH391/S2013 Pages]]
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Topic choices should be discussed with the instructor at least '''one week''' prior to the scheduled presentation. A list of topics can be found below, but there is significant leeway to tailor the papers and topics toward your specific interests.
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[[Special:RecentChangesLinked/Category:CH391L_S2013 | View Recent Changes to CH391/S2013 Pages]]
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Us this page to brainstorm or suggest possible topics and ideas
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== Double Strand Break (DSB) Repair ==
== Double Strand Break (DSB) Repair ==
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** Werner & Bloom Syndromes
** Werner & Bloom Syndromes
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== DNA Replication as a Source of Genomic Instability ==
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== DNA Replication and Genomic Instability ==
* Replicating Aberrant Structures
* Replicating Aberrant Structures
** DNA Hairpins
** DNA Hairpins
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== p53 -- The Guardian of the Genome ==
== p53 -- The Guardian of the Genome ==
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== Student-selected topic ==
 

Current revision

Contents

Topics

Us this page to brainstorm or suggest possible topics and ideas

Topic choices should be discussed with the instructor at least one week prior to the scheduled presentation. A list of topics can be found below, but there is significant leeway to tailor the papers and topics toward your specific interests.

Double Strand Break (DSB) Repair

  • DSB repair mechanisms in prokaryotes
    • Homologous Recombination
    • SOS Response
  • DSB repair in eukaryotes
    • Homologous Recombination
    • Non-Homologous End Joining
    • Alternative End-Joining
  • DSB Repair: Pathway Choice
  • DSB-related diseases:
    • Seckel & Jawad Syndromes
    • Nijmegen Breakage Syndrome
    • Ataxia - telangiectasia
    • Werner & Bloom Syndromes

DNA Replication and Genomic Instability

  • Replicating Aberrant Structures
    • DNA Hairpins
    • Z-DNA
    • G-Quadruplex DNA
    • Chromosome Fragile Sites
  • Replication-Transcription Conflicts
  • Replication-Collapse at Interstrand Cross Links

Mechanisms of DNA Mismatch Repair

  • Mismatch Repair in Prokaryotes
  • Very short patch repair
  • Mismatch Repair in Eukaryotes
    • How is a Mismatch Recognized?
    • How is a Mismatch Removed?
  • Mismatch repair and adaptation
    • Mutagenesis in Bacteria
    • Mutagenesis in Eukaryotes
  • Meiotic-specific Roles of Mismatch Repair Proteins
  • Diseases
    • Lynch Syndrome

Mitochondrial DNA Damage

  • Structure of Mitochondrial DNA
  • Mechanisms of DNA Repair
  • Mitochondrial DNA repair and aging
  • Diseases Associated with Mitochondrial DNA Damage

Nucleotide Excision Repair

Base Excision Repair

Damage Tolerance and Mutagenesis

  • Prokaryotes
    • Error-prone translesion synthesis
    • Living with chronic damage
  • Eukaryotes
    • Error-prone translesion synthesis
    • Living with chronic damage

Cell-cycle response to DNA damage

Systems approaches to cancer research

  • Global analysis of transcription changes
  • Global analysis of siRNA changes in cancer cells

p53 -- The Guardian of the Genome

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