CH391L/S2013/SuggestedTopics

Topics

Us this page to brainstorm or suggest possible topics and ideas

Double Strand Break (DSB) Repair

• DSB repair mechanisms in prokaryotes
  • Homologous Recombination
  • SOS Response

• DSB repair in eukaryotes
  • Homologous Recombination
  • Non-Homologous End Joining
  • Alternative End-Joining

• DSB Repair: Pathway Choice

• DSB-related diseases:
  • Seckel & Jawad Syndromes
  • Nijmegen Breakage Syndrome
  • Ataxia - telangiectasia
  • Werner & Bloom Syndromes

DNA Replication and Genomic Instability

• Replicating Aberrant Structures
  • DNA Hairpins
  • Z-DNA
  • G-Quadruplex DNA
  • Chromosome Fragile Sites

• Replication-Transcription Conflicts
• Replication-Collapse at Interstrand Cross Links

Mechanisms of DNA Mismatch Repair

• Mismatch Repair in Prokaryotes
• Very short patch repair
• Mismatch Repair in Eukaryotes
  • How is a Mismatch Recognized?
  • How is a Mismatch Removed?

• Mismatch repair and adaptation
  • Mutagenesis in Bacteria
  • Mutagenesis in Eukaryotes

• Meiotic-specific Roles of Mismatch Repair Proteins

• Diseases
  • Lynch Syndrome

Mitochondrial DNA Damage

• Structure of Mitochondrial DNA
• Mechanisms of DNA Repair
• Mitochondrial DNA repair and aging
• Diseases Associated with Mitochondrial DNA Damage

Damage Tolerance and Mutagenesis

• Prokaryotes
  • Error-prone translesion synthesis
  • Living with chronic damage
• Eukaryotes
  • Error-prone translesion synthesis
  • Living with chronic damage

Systems approaches to cancer research

• Global analysis of transcription changes
• Global analysis of siRNA changes in cancer cells