CH391L/S2013 Taylor Pursell April 3 2013

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Hereoplastic mitochondrial DNA mutations in normal and tumor cells by Yiping He et al.

Contents

Background

Mitochondria

Mitochondria is a membrane enclose organelle found in most eukaryotic cells. They were first visualized in the 1950s visualized in chick cells with electron microscopy [1]. Mitochondria generate most of the cell’s ATP; they are also involed in signaling, differentiation, cell death, control of cell cycle and cell growth [2]. All mitochondria share a few characteristics included double lipid membrane and inner membrane folds called cristae. Although the mitochondria first visualized were bean shaped, further research has revealed that mitochondrial morphology varies greatly between cell types and even within the same cell [1].

The number of mitochondria in a cells is .

Mitochondrial Genome

Each mitochondrion contains five to ten copies of the mitochondrial genome.s had

Introduction

Methods

Results

Significance

References

  1. Detmer, S. A. and Chan, D. C. Functions and dysfunctions of mitochondrial dynamics. Nature 8: 870-879 (2007)
  2. McBride, H. M., Neuspiel, M., Wasiak, S. Mitochondria: more than just a powerhouse. Current Biology 16: R551-R560 (2006)
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