CHE.496/2008/Responses/a5

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(Natural biological parts)
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**Codon bias and heterologous protein expression
**Codon bias and heterologous protein expression
***Gustaffson's paper deals with codon bias in organisms. In brief, different organisms have a bias towards codons for protein expression. For example, while two different codons may code for one amino acid, they may each work better in different organisms. While Gustaffson points out some areas in which care should be taken (i.e. repetitive sequences), companies such as DNA2.0 offer free software to easily complete codon optimization.
***Gustaffson's paper deals with codon bias in organisms. In brief, different organisms have a bias towards codons for protein expression. For example, while two different codons may code for one amino acid, they may each work better in different organisms. While Gustaffson points out some areas in which care should be taken (i.e. repetitive sequences), companies such as DNA2.0 offer free software to easily complete codon optimization.
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Revision as of 22:25, 29 January 2008

CHE.496: Biological Systems Design Seminar

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Natural biological parts


  • Kevin Hershey
    • Another side of genomics: Synthetic biology as a means for the exploitation of whole-genome sequence information
      • Stahler's main focus in this paper is on the development of in situ microarray analysis. Such examples of these array-derived oligos include the Maskless Array Synthesizer and the use of a microfluidic synthesiser platform. He discusses how this new advancement will allow for cheaper and quicker synthetic biology. However, Stahler's definition of synthetic biology is different from the previous papers discussed in this class. He defines synthetic biology simply as "... the making and use of biosystems founded on the synthesis of the coding DNA (and potentially RNA) based upon chemically synthesised nucleic acids oligonucleotides of programmable sequences." However, even though his definition is different than ours, it is still a useful tool to be used in the practice of synthetic biology for the iGEM competition.
    • Codon bias and heterologous protein expression
      • Gustaffson's paper deals with codon bias in organisms. In brief, different organisms have a bias towards codons for protein expression. For example, while two different codons may code for one amino acid, they may each work better in different organisms. While Gustaffson points out some areas in which care should be taken (i.e. repetitive sequences), companies such as DNA2.0 offer free software to easily complete codon optimization.
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