CHE.496/2009/Responses/a12
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Systems biology and synthetic biology
- Discussion leader: Brandon
Thaddeus Webb's Response
Systems biology as a foundation for genome-scale synthetic biology
- Offers ideas about how synthetic and systems biology will come together.
- The goal of reconstruction would be the composition of a mathematical model describing all of the parts of a biological system accurately.
- Currently use stoichiometric matrix for reconstruction.
- Will benefit from high input data experiments
- Will need to define parameters to turn reconstructions into models
- Software and computing will drive synthetic biology.
- Until models are extremely accurate systems will require the use of directed evolution to be tuned.
- Tying optimization to growth is an effective way to direct evolution.
Network Benchmarking: A Happy Marriage between Systems and Synthetic Biology
- Outlines the mutualism between synthetic and systems biology.
- Systems biology modeling will enable synthetic design.
- A five gene system was created
- Had well defined parts
- robust against cellular inputs
- interesting abilities
- easy external control
- Designers used this network to estimate parameters.
Thaddeus Webb 23:05, 1 April 2009 (EDT)
Patrick Gildea's Response
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- Network Benchmarking: A Happy Marriage between Systems and Synthetic Biology
- Patrick Gildea 12:01, 2 April 2009 (EDT):
