CHE.496/2009/Schedule/Oral presentations of part design/Group 4

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====ppGpp responsive promoter====
'''Purpose'''
'''Purpose'''
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<p>text</p>
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<p>This promoter would be able to turn on genes in response to the stringent response mechanism in bacteria, including amino-acid and carbon starvation.</p>
'''Description'''
'''Description'''
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<p>[http://en.wikipedia.org/wiki/PpGpp ppGpp(p)] is an alarmone which gets produced in response to low levels of amino acids in the cell. Having a promoter responsive to this cellular signal would allow an engineered response certain types of stress on the cell. An example would be to put your synthetic metabolic network under control of a promoter that either gets directly inhibited by this signal or alternately, have such a promoter cause the production of an inhibitor for your synthetic genes.</p>
'''Source & References'''
'''Source & References'''
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# [http://dx.doi.org/10.1016/j.tim.2005.03.008 Magnusson et al. (2005) Trends in Microbiology 13, 236]
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====Part 6====
====Part 6====
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Revision as of 12:05, 12 April 2009

CHE.496: Biological Systems Design Seminar

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Group 4

  • Members: Dan Tarjan & George Washington

Parts

  • Part 1
    • Description
    • Source & References
  • Part 2
  • Part 3
  • Part 4


ppGpp responsive promoter

Purpose

This promoter would be able to turn on genes in response to the stringent response mechanism in bacteria, including amino-acid and carbon starvation.

Description

ppGpp(p) is an alarmone which gets produced in response to low levels of amino acids in the cell. Having a promoter responsive to this cellular signal would allow an engineered response certain types of stress on the cell. An example would be to put your synthetic metabolic network under control of a promoter that either gets directly inhibited by this signal or alternately, have such a promoter cause the production of an inhibitor for your synthetic genes.

Source & References

  1. Magnusson et al. (2005) Trends in Microbiology 13, 236

Part 6

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