Caltech Synthetic Biology Journal Club

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SynBio @ Caltech We are a journal club at Caltech, getting graduate students together to discuss synthetic biology and metabolic engineering. Meetings First meeting 1/21/2011, 4pm, location TBA. Weekly Topics We'll start with a broad introduction to popular topics in synthetic biology, then figure out the logistics for future weeks - this will most likely involve rotating responsibility for presenting material each week. Week 1: Introduction to Synthetic Biology (Emzo and Joe) Synthetic biology: new engineering rules for an emerging discipline. Andrianantoandro E, Basu S, Karig DK and Weiss R. Mol Sys Bio. 2:2006.0028 [1] Synthetic biology: applications come of age. Khalil AS and Collins JJ. Nature Reviews Genetics 11: 367-379 (2010) [2] Week 2: Nucleotide Level Control (Emzo) Construction of a genetic toggle switch in Escherichia coli. Gardner TS, Cantor CR and Collins JJ. Nature 403: 339-342 (2000). [3] Synthetic gene networks that count. Friedland AE, Lu TK, Wang X, Shi D, Church G, Collins JJ. Science 324:1199-1202 (2009). [4] Week 3: Oscillators & Dynamics (Emzo) A Synthetic Oscillatory Network of Transcriptional Regulators. Elowitz MB, Leibler S. Nature. 403:335-8. (2000) [5] A fast, robust and tunable synthetic gene oscillator. Stricker J, Cookson S, Bennett MR, Mather WH, Tsimring LS, Hasty J. Nature. 456:516-19 (2008) [6] Week 4: RNA Based Regulation (Joe) Week 5: Multiple Genes - Gene Network Engineering (Joe) Week 6: Multiple Cells - Quorum Sensing and Cell-Cell Communication (Joe) Other Join the listserv