Carbohydrate vaccines

Overview

Vaccines using carbohydrates!

Background

Advantages:

• Pathogenic cell surfaces usually have distinct and characteristic carbohydrate proteins which can be targeted (Hecht)
• The fast mutation rates in pathogens does not directly affect the carbohydrates on the cell surface (Hecht)

Disadvantages (for now):

• Often difficult to isolate carbohydrates (Hecht)

Papers on the topic

Carbohydrate moieties as vaccine candidates, Lucas AH et al: http://www.ncbi.nlm.nih.gov/pubmed/16080094

Carbohydrate-based vaccines: challenges and opportunities, Huang YL et al: http://www.ncbi.nlm.nih.gov/pubmed/21087106

Carbohydrate Moieties as Vaccine Candidates: meeting summary, Lucas AH, et al,

Carbohydrate based vaccines, Bijvoet Center et al. : http://www.ncbi.nlm.nih.gov/pubmed/16630616

Vliegenthart, Johannes F. G. Carbohydrate based vaccines. (2006). FEBS Letters 580, 2945-2950.

Hecht, Marie-Lyn., Stallforth, Pierre., Silva, Daniel Varon., Adibekian, Alexander.,& Seeberger, Peter H. Recent advances in carbohydrate-based vaccines.(2009). Current Opinion In Chemical Biology 13, 354-359.

http://www.ncbi.nlm.nih.gov/pubmed/19560394

Bioinformatics and molecular modeling in glycobiology (about carbohydrates in general, might need it as reference), Frank M et al : http://www.ncbi.nlm.nih.gov/pubmed/20364395