Carragee

Department of Physics, Willamette University

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I'm a senior biochemistry major from the Palo Alto, Ca. My thesis is a collaboration between the chemistry department, physics department and the Spudich lab at Stanford. I'm looking at a mutation in myosin VI, a motor protein in human cardiac muscle, that has been genetically linked to hypertrophic cardiomyopathy. Myosin, like many cellular motors, works by hydrolyzing ATP for energy. I'll be using three bead assays in the optical trap to study the chemomechanical cycle the myosin motor undergoes by comparing the mutated at H246R to the wild type motor.