Cellular and molecular bioengineering laboratory

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Welcome to the cellular & molecular bioengineering lab wiki in [[Main_Page | OPENWETWARE]].
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[[Image:CellCover4.jpg|thumb|300px|right|Bardet-Biedl Syndrome (BBS): a disease of the cilium.<br> BBS patients suffer from retinal degeneration (upper left), kidney malformations (lower right), obesity and polydactyly (upper right). Recently, we discovered that a core complex of BBS proteins (the BBSome) coordinates vesicular transport to the primary cilium (lower left).]]
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The Nachury Lab is part of the department of [http://mcp.stanford.edu/ Molecular and Cellular Physiology] at [http://med.stanford.edu/ Stanford University School of Medicine].<br>Our lab is interested in using a combination of interdisciplinary approaches encompassing protein biochemistry, cell biology, in vitro assays, digital microscopy and mammalian cell engineering to study the molecular etiology of complex hereditary human diseases.<br>
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A major focus of the lab is the study of the primary cilium, a once-obscure cellular organelle that has recently been "re-discovered" for its role in a number of signaling pathways (Hedgehog, Planar Cell Polarity, PDGF,..). Most fascinatingly, molecular defects in cilium biogenesis lead to a variety of hereditary disorders (so-called "ciliopathies") characterized by retinal degeneration, kidney cysts, brain malformations, obesity, polydactyly, randomization of left-right asymmetry, etc. Our major goal is to characterize these ciliopathies at the molecular and cellular levels to gain insight into the basic mechanisms of primary cilium biogenesis and to discover novel ciliary signaling pathways.
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== Research Information ==
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== Resources ==
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==Educational Programs==
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== Lab Information ==
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Images on this page provided by Chris Brown and Caroline Ajo-Franklin. 
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Wiki Editing [[Silver: Wiki Instructions|Instructions]]
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Lab members, also visit the [https://silver.med.harvard.edu/passwd/wiki/index.php?title=Main_Page secure wiki].
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Revision as of 01:40, 17 July 2008

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Bardet-Biedl Syndrome (BBS): a disease of the cilium. BBS patients suffer from retinal degeneration (upper left), kidney malformations (lower right), obesity and polydactyly (upper right). Recently, we discovered that a core complex of BBS proteins (the BBSome) coordinates vesicular transport to the primary cilium (lower left).
Bardet-Biedl Syndrome (BBS): a disease of the cilium.
BBS patients suffer from retinal degeneration (upper left), kidney malformations (lower right), obesity and polydactyly (upper right). Recently, we discovered that a core complex of BBS proteins (the BBSome) coordinates vesicular transport to the primary cilium (lower left).

The Nachury Lab is part of the department of Molecular and Cellular Physiology at Stanford University School of Medicine.
Our lab is interested in using a combination of interdisciplinary approaches encompassing protein biochemistry, cell biology, in vitro assays, digital microscopy and mammalian cell engineering to study the molecular etiology of complex hereditary human diseases.
A major focus of the lab is the study of the primary cilium, a once-obscure cellular organelle that has recently been "re-discovered" for its role in a number of signaling pathways (Hedgehog, Planar Cell Polarity, PDGF,..). Most fascinatingly, molecular defects in cilium biogenesis lead to a variety of hereditary disorders (so-called "ciliopathies") characterized by retinal degeneration, kidney cysts, brain malformations, obesity, polydactyly, randomization of left-right asymmetry, etc. Our major goal is to characterize these ciliopathies at the molecular and cellular levels to gain insight into the basic mechanisms of primary cilium biogenesis and to discover novel ciliary signaling pathways.


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