Our lab is interested in transposons using an approach combining biochemistry, cell biology, bioinformatics and mathematical modelling.
The main focuses of the lab are on:
- Determination of the mariner transposition mechanism
- Molecular domestication of mariner transposons in the human genome
- Development of mariner transposons as gene vectors
Last paper: Claeys Bouuaert C, Chalmers R. Hsmar1 Transposition Is Sensitive to the Topology of the Transposon Donor and the Target. PLoS ONE. 2013 Jan 14;8(1): e53690.