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<h3>Research</h3> | <h3>Research</h3> | ||
All organisms must pass an intact genome onto their progeny, so we are interested how chromosomes are faithfully inherited when cells divide. The centromere is the position on a chromosome where it attaches to the mitotic spindle, facilitating correct segregation. We study chromosome properties that specify centromere location and function | All organisms must pass an intact genome onto their progeny, so we are interested how chromosomes are faithfully inherited when cells divide. The centromere is the position on a chromosome where it attaches to the mitotic spindle, facilitating correct segregation. We study chromosome properties that specify centromere location and function. | ||
[[Chan:Research|Learn more]] | [[Chan:Research|Learn more]] |
Revision as of 01:00, 28 November 2007
Simon Chan Lab
Welcome to the Chan Lab, in the Section of Plant Biology at UC Davis.
We study chromosome inheritance during cell division using the small flowering plant Arabidopsis thaliana.
Lab MembersCurrent |
ResearchAll organisms must pass an intact genome onto their progeny, so we are interested how chromosomes are faithfully inherited when cells divide. The centromere is the position on a chromosome where it attaches to the mitotic spindle, facilitating correct segregation. We study chromosome properties that specify centromere location and function. Publications |
Resources• Protocols Contact UsLife Sciences Building LS1215 (lab) |
Publications
Two-step recruitment of RNA-directed DNA methylation to tandem repeats. Increased outcrossing in hothead mutants. Genome-wide High-Resolution Mapping and Functional Analysis of DNA Methylation in Arabidopsis. An ARGONAUTE4-containing nuclear processing center co-localized with Cajal bodies in Arabidopsis thaliana. RNAi, DRD1 and Histone Methylation Actively Target Developmentally Important Non-CG DNA Methylation in Arabidopsis. Gardening the genome: DNA methylation in Arabidopsis thaliana. Applications of DNA tiling arrays for whole-genome analysis. siRNA-induced transcriptional gene silencing in human cells. RNA silencing genes control de novo DNA methylation.
Telomeres and telomerase. Telomerase and ATM/Tel1p protect telomeres from non-homologous end-joining. New ways not to make ends meet: telomerase, DNA damage proteins and heterochromatin. Altering telomere structure allows telomerase to act in yeast lacking ATM kinases. Molecular manifestations and molecular determinants of telomere capping. |