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| <font face="Helvetica" size=6 color=#00cc00> | | <font face="Helvetica" size=6 color=#339900> |
| | | '''Chan Lab'''<br> |
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| '''Simon Chan Lab'''<br> | |
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| [http://www-plb.ucdavis.edu/index.html Section of Plant Biology] at [http://www.ucdavis.edu/ UC Davis]
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| | <br> |
| | '''''"finest haploids since 2009"'''''<br> |
| | [http://www-plb.ucdavis.edu/ Department of Plant Biology], [http://www.ucdavis.edu/ UC Davis] and [http://www.hhmi.org HHMI] |
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| [[Image:arabidopsis.jpg|left|thumb||200 px|<i>Arabidopsis thaliana</i>]]
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| <font face="Helvetica"><b>Welcome to the Chan Lab at UC Davis.</b>
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| We study chromosome inheritance and centromere function using the small flowering plant <i>[http://www.arabidopsis.org/portals/education/aboutarabidopsis.jsp Arabidopsis thaliana]</i>.
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| <div style="padding: .4em .9em .9em"> | | <div style="padding: .4em .9em .9em"> |
| | [[Chan|Home]] |
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| | [[Chan:Research|Research]] |
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| | [[Chan:Publications|Publications]] |
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| | [[Chan:People|People]] |
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| | [[Chan:Links|Links]] |
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| | [[Chan:Bioinformatics Sites|Bioinformatics]] |
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| | [[Chan:Contact|Contact]] |
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| <h3>Lab Members</h3>
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| • [[Chan:Simon Chan|Dr. Simon Chan]]<BR>
| | '''Welcome to Simon Chan's Lab''' |
| • [[Chan:Joseph Ramahi|Joseph Ramahi]]<BR>
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| • [[Chan:Pak Kwong|Pak Kwong]]<BR>
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| • [[Chan:Christian Santa Maria|Christian Santa Maria]]<BR>
| | '''With deep regret we inform you that Simon Chan (1974-2012) has passed away on Aug 22nd at an age of 38 '''<br> |
| • [[Chan:Ron Menorca|Ron Menorca]]<BR>
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| • Jessica Wald, rotation student<br>
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| <br> | | <br> |
| [[Chan:Information about joining our lab|Information about joining our lab]]
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| <h3>Former Lab Members</h3>
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| • [[Chan:Jodi Stewart|Jodi Stewart]]<BR>
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| <h3>Research</h3>
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| more to come soon
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| <h3>Resources</h3>
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| • [[Chan:Protocols|Protocols]]<br>
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| • [[Chan:Teaching|Teaching]]<br>
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| • [[Chan:Links|Links]]<br>
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| • [[Chan:Resources|UC Davis Facilities and Resources]]<br>
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| • [[Chan:Bioinformatics Sites|Bioinformatics Sites]]<br>
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| • [http://comailab.genomecenter.ucdavis.edu/index.php/Lab_Meeting Lab Meeting Schedule]<br></div>
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| <h3>Contact Us</h3>
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| Life Sciences Building LS1215 (lab)<br>
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| Life Sciences Building LS1220 (office)<br>
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| <b>Lab Phone:</b> (530) 754 9789<br>
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| <b>Office Phone:</b> (530) 754 9652<br>
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| <b>e-mail:</b> srchan [ at ] ucdavis.edu<br>
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| <h3><b>Publications</b></h3>
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| Please contact Simon if you would like the pdf file.<br>
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| <br> | | <br> |
| <b>Postdoc research on DNA methylation and gene silencing:</b>
| | Additional information can be found on the [http://bmcdb.wordpress.com BMCDB blog] and the [http://www.plb.ucdavis.edu/labs/srchan/ Department of Plant Biology website].<br> |
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| Two-step recruitment of RNA-directed DNA methylation to tandem repeats.<br>
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| Chan, S.W.L., Zhang, X.Y., Bernatavichute, Y.V. and Jacobsen, S.E.<br>
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| PLoS Biology 4 No. 11 e363 (2006)
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| Increased outcrossing in ''hothead'' mutants.<br>
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| Peng P., Chan, S.W.L., Shah, G.A. and Jacobsen, S.E.<br>
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| Nature 443, E8 (2006)
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| Genome-wide High-Resolution Mapping and Functional Analysis of DNA Methylation in ''Arabidopsis''.<br>
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| Zhang, X.*, Yazaki, J.*, Sundaresan, A.*, Cokus, S.*, Chan, S.W.L., Chen, H., Henderson, I.R., Shinn, P., Pellegrini, M., Jacobsen, S.E., and Ecker, J.R.<br>
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| Cell 126, 1189-1201 (2006)
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| An ARGONAUTE4-containing nuclear processing center co-localized with Cajal bodies in ''Arabidopsis thaliana''.<br>
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| Li, C.F., Pontes, O., El-Shami, M., Henderson, I.R., Bernatavichute, Y.V., Chan, S.W.L., Lagrange, T., Pikaard, C.S. and Jacobsen, S.E.<br>
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| Cell 126, 93-106 (2006)
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| RNAi, DRD1 and Histone Methylation Actively Target Developmentally Important Non-CG DNA Methylation in ''Arabidopsis''.<br>
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| Chan, S.W.L., Henderson, I.R., Zhang, X.Y., Chien, J.S.C., Shah, G. and Jacobsen, S.E.<br>
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| PLoS Genetics 2, No. 6 e83 (2006)
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| Gardening the genome: DNA methylation in ''Arabidopsis thaliana''.<br>
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| Chan, S.W.L.*, Henderson, I.R.* and Jacobsen, S.E.<br>
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| Nature Reviews Genetics 6, 351-360 (2005) [review article]
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| Applications of DNA tiling arrays for whole-genome analysis.<br>
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| Mockler, T.C., Chan, S., Sundaresan A., Chen, H., Jacobsen S.E. and Ecker, J.R.<br>
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| Genomics 85, 1-15 (2005) [review article]
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| siRNA-induced transcriptional gene silencing in human cells.<br>
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| Morris, K.V., Chan, S.W.L., Jacobsen, S.E. and Looney, D.J.<br>
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| Science 305, 1289-1292 (2004)
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| RNA silencing genes control de novo DNA methylation.<br>
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| Chan, S.W.L., Zilberman D., Xie, Z., Johansen, L.K., Carrington, J.C. and Jacobsen, S.E.<br>
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| Science 303, 1336 (2004)
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| <b>PhD research on telomeres and telomerase:</b>
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| Telomeres and telomerase.<br>
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| Chan, S.R.W.L. and Blackburn, E.H.<br>
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| Phil. Trans. R. Soc. Lond. B 359, 109-121 (2004)
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| Telomerase and ATM/Tel1p protect telomeres from non-homologous end-joining.<br>
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| Chan, S.W.L. and Blackburn, E.H.<br>
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| Molecular Cell 11, 1379-1387 (2003)
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| New ways not to make ends meet: telomerase, DNA damage proteins and heterochromatin.<br>
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| Chan, S.W.L. and Blackburn, E.H.<br>
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| Oncogene 21, 553-563 (2002) [review article]
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| Altering telomere structure allows telomerase to act in yeast lacking ATM kinases.<br>
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| Chan, S.W.L., Chang, J., Prescott, J. and Blackburn, E.H.<br>
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| Current Biology 11, 1240-1250 (2001)
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| Molecular manifestations and molecular determinants of telomere capping.<br>
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| Blackburn, E.H., Chan, S., Chang, J., Fulton, T.B., Krauskopf, A., McEachern, M., Prescott, J., Roy, J., Smith, C. and Wang, H.<br>
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| Cold Spring Harbor Symposia on Quantitative Biology, 65, 253-263 (2000)<br>
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| <br> | | <br> |
| note: * denotes equal contribution<br>
| | <br>'''For any comments, notes, or requests, please contact Ravi at ravigenome@gmail.com Mohan at mpamarimuthu@ucdavis.edu or Han at suprduprhan@gmail.com'''<br> |
| | </font><br><br> |
| | <font face="Helvetica" size=2> |
| | We study chromosome inheritance using the small plant <i>[http://www.arabidopsis.org/portals/education/aboutarabidopsis.jsp Arabidopsis thaliana]</i>. |
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| | |width=500px class="MainPageBG" style="border: 0px solid #cc3300; background-color: #ffffff"| |
| | [[Image:haploids.jpg|thumb|none|365 px|Haploid plants (represented by pink pots) have only one copy of each chromosome, and are very useful in plant breeding. We have produced haploids by manipulating centromeres. Image by [http://www.onemicron.com/ Janet Iwasa].]] |
| | <br>''''''<br> |
| | </font> |
| | |} |