Chan

Simon Chan Lab

Arabidopsis thaliana

Welcome to the Chan Lab at UC Davis. We study chromosome inheritance and genome stability using the small flowering plant Arabidopsis thaliana.

Lab Members • Dr. Simon Chan • Joseph Ramahi • Pak Kwong • Christian Santa Maria • Ron Menorca Former Lab Members • Jodi Stewart

Research more to come soon

Resources • Protocols • Teaching • Links • Bioinformatics Sites

Contact Us Life Sciences Building LS1215 (lab) Life Sciences Building LS1220 (office) Lab Phone: (530) 754 9789 Office Phone: (530) 754 9652 e-mail: srchan [ at ] ucdavis.edu

Publications Please contact Simon if you would like the pdf file. Postdoc research on DNA methylation and gene silencing: Two-step recruitment of RNA-directed DNA methylation to tandem repeats. Chan, S.W.L., Zhang, X.Y., Bernatavichute, Y.V. and Jacobsen, S.E. PLoS Biology 4 No. 11 e363 (2006) Increased outcrossing in hothead mutants. Peng P., Chan, S.W.L., Shah, G.A. and Jacobsen, S.E. Nature 443, E8 (2006) Genome-wide High-Resolution Mapping and Functional Analysis of DNA Methylation in Arabidopsis. Zhang, X.*, Yazaki, J.*, Sundaresan, A.*, Cokus, S.*, Chan, S.W.L., Chen, H., Henderson, I.R., Shinn, P., Pellegrini, M., Jacobsen, S.E., and Ecker, J.R. Cell 126, 1189-1201 (2006) An ARGONAUTE4-containing nuclear processing center co-localized with Cajal bodies in Arabidopsis thaliana. Li, C.F., Pontes, O., El-Shami, M., Henderson, I.R., Bernatavichute, Y.V., Chan, S.W.L., Lagrange, T., Pikaard, C.S. and Jacobsen, S.E. Cell 126, 93-106 (2006) Chan, S.W.L., Henderson, I.R., Zhang, X.Y., Chien, J.S.C., Shah, G. and Jacobsen, S.E. RNAi, DRD1 and Histone Methylation Actively Target Developmentally Important Non-CG DNA Methylation in Arabidopsis. PLoS Genetics 2, No. 6 e83 (2006) Chan, S.W.L.*, Henderson, I.R.* and Jacobsen, S.E. Gardening the genome: DNA methylation in Arabidopsis thaliana. Nature Reviews Genetics 6, 351-360 (2005) [review article] Mockler, T.C., Chan, S., Sundaresan A., Chen, H., Jacobsen S.E. and Ecker, J.R. Applications of DNA tiling arrays for whole-genome analysis. Genomics 85, 1-15 (2005) [review article] Morris, K.V., Chan, S.W.L., Jacobsen, S.E. and Looney, D.J. siRNA-induced transcriptional gene silencing in human cells. Science 305, 1289-1292 (2004) Chan, S.W.L., Zilberman D., Xie, Z., Johansen, L.K., Carrington, J.C. and Jacobsen, S.E. RNA silencing genes control de novo DNA methylation. Science 303, 1336 (2004) PhD research on telomeres and telomerase: Chan, S.R.W.L. and Blackburn, E.H. Telomeres and telomerase. Phil. Trans. R. Soc. Lond. B 359, 109-121 (2004) Chan, S.W.L. and Blackburn, E.H. Telomerase and ATM/Tel1p protect telomeres from non-homologous end-joining. Molecular Cell 11, 1379-1387 (2003) Chan, S.W.L. and Blackburn, E.H. New ways not to make ends meet: telomerase, DNA damage proteins and heterochromatin. Oncogene 21, 553-563 (2002) [review article] Chan, S.W.L., Chang, J., Prescott, J. and Blackburn, E.H. Altering telomere structure allows telomerase to act in yeast lacking ATM kinases. Current Biology 11, 1240-1250 (2001) Blackburn, E.H., Chan, S., Chang, J., Fulton, T.B., Krauskopf, A., McEachern, M., Prescott, J., Roy, J., Smith, C. and Wang, H. Molecular manifestations and molecular determinants of telomere capping. Cold Spring Harbor Symposia on Quantitative Biology, 65, 253-263 (2000) * denotes equal contribution