Daniël joined the lab in Spring of 2009, and his research project is focused on the evolution of the centromere tandem repeat sequences in over 300 eurkaryotes using bioinformatics.
Daniël received his BSc and MSc from Leiden University in the Netherlands. For his MSc he worked in Dr. Lipsky's lab at the NIH, studying the B lymphocyte immunoglobulin heavy chain repertoire. For his MSc thesis, Daniël worked in Prof. Dr. de Kloet's lab at the LACDR / Leiden University identifying SNPs in the mineralocorticoid receptor promoter of different inbred mouse strains. Following his MSc he moved to San Francisco where Daniël joined Dr. Pearce's lab at UCSF, working on understanding the signaling cascade regulation sodium reabsorption in kidney epithelium cells upon aldosterone treatment. His work has led to three publications:
- Soundararajan R, Wang J, Melters DP, Pearce D. Glucocorticoid-induced leucine zipper 1 stimulates the epithelial sodium channel by regulating serum- and glucocorticoid-induced kinase 1 stability and subcellular localization. J. Biol. Chem.2010link
- Soundararajan R, Melters DP, Shih IC, Wang J, Pearce D. Epithelial sodium channel regulated by differential composition of a signaling complex. Proc. Natl. Acad. Sci. U.S.A.2009 106(19):7804-7809. link
- Soundararajan R, Wang J, Melters DP, Pearce D. Differential activities of glucocorticoid-induced leucine zipper protein isoforms. J. Biol. Chem.2007 Dec 14;282(50):36303-13. link