Chan:Han Tan

Chan Lab

Department of Plant Biology at UC Davis

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Han is interested in chromosome shattering during genomic catastrophes and is currently investigating complex chromosomal rearrangements caused by chromosome segregation errors. He is also developing tools to engineer and rapidly shuffle artificial linear minichromosome platforms via haploid induction. 2005-2011 Washington University in St Louis, Ph.D. in Molecular Genetics & Genomics Graduate work was focused on the surprising role of variant non-catalytic subunits in the functional specification of RNA silencing RNA Polymerases IV and V beyond the catalytic subunits for small RNA directed DNA methylation pathway, as well as the role of DNA demethylation in multi-megabase epigenetic silencing in Craig Pikaard's lab. 2001-2005 Duke University, B.S., Biology & Visual Arts Double Major, Chemistry Minor Undergraduate research contribution involves a forward genetics screen for genes regulating Innate Immunity in Xinnian Dong's lab. List of publications: Tan, E.H., Ream, T.S., Blevins, T. and Pikaard, C.S. (2012) Functional consequences of subunit diversity in RNA Polymerase II and V. Cell Reports. In press. Mosher, A. R., Tan, E.H., Shin, J., Fischer, R.L., Pikaard, C.S., Baulcombe, D.C. (2011) An atypical epigenetic mechanism affects uniparental expression of Pol IV-dependent siRNAs. PloS ONE 6(10): e25756. Song, J., Durrant, W.E., Wang, S., Yan, S., Tan, E.H., Dong, X. (2011) DNA repair proteins are directly involved in regulation of gene expression during plant Immune Response. Cell Host & Microbe, 9(2): 115-124.