Chan:Research: Difference between revisions
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'''Centromeres: Controllers of Inheritance'''<br> | '''Centromeres: Controllers of Inheritance'''<br> | ||
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(You can also read about our research at the [http://www.hhmi.org/research/hhmi-gbmf/chans.html HHMI website])<br> | |||
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We study the fundamental biology of genetic inheritance, and aim to manipulate it for practical benefit. Centromeres control chromosome segregation during cell division, because they are the loci at which chromosomes attach to spindle microtubules via the kinetochore protein complex. Centromere DNA in most plants and animals consists of megabases of simple tandem repeats. These sequences can be dispensable for centromere function. Instead, the centromere is epigenetically specified by CENH3, a centromere-specific histone H3 variant that replaces conventional H3 in centromeric nucleosomes, and is essential for recruiting other kinetochore proteins.<br> | We study the fundamental biology of genetic inheritance, and aim to manipulate it for practical benefit. Centromeres control chromosome segregation during cell division, because they are the loci at which chromosomes attach to spindle microtubules via the kinetochore protein complex. Centromere DNA in most plants and animals consists of megabases of simple tandem repeats. These sequences can be dispensable for centromere function. Instead, the centromere is epigenetically specified by CENH3, a centromere-specific histone H3 variant that replaces conventional H3 in centromeric nucleosomes, and is essential for recruiting other kinetochore proteins.<br> |
Latest revision as of 15:40, 25 November 2011
Chan Lab
Department of Plant Biology, UC Davis and HHMI
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Centromeres: Controllers of Inheritance |