Chandra:Research:Computational immunology

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(New page: A key step in rational vaccine development is to understand how antigens are recognized by their receptors. Several crystal structures of MHC/HLA molecules are now available. We have perfo...)
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Revision as of 12:53, 24 August 2007

A key step in rational vaccine development is to understand how antigens are recognized by their receptors. Several crystal structures of MHC/HLA molecules are now available. We have performed a structural bioinformatics study of peptide- HLA complexes to derive features that generate recognition specificity, useful for guiding the design process.

Image:Chandra:StructSuperposition.jpg
Structural superposition of MHC Class I alleles
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