Chandra:Research:Computational immunology

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(New page: A key step in rational vaccine development is to understand how antigens are recognized by their receptors. Several crystal structures of MHC/HLA molecules are now available. We have perfo...)
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{{ChandraLab}}
A key step in rational vaccine development is to understand how antigens are recognized by their receptors. Several crystal structures of MHC/HLA molecules are now available. We have performed a structural bioinformatics study of peptide- HLA complexes to derive features that generate recognition specificity, useful for guiding the design process.
A key step in rational vaccine development is to understand how antigens are recognized by their receptors. Several crystal structures of MHC/HLA molecules are now available. We have performed a structural bioinformatics study of peptide- HLA complexes to derive features that generate recognition specificity, useful for guiding the design process.
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[[Image:Chandra:StructSuperposition.jpg|thumbnail|200px|left|Structural superposition of MHC Class I alleles]]
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[[Image:Chandra-StructSuperposition.jpg|thumbnail|200px|left|Structural superposition of MHC Class I alleles]]

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A key step in rational vaccine development is to understand how antigens are recognized by their receptors. Several crystal structures of MHC/HLA molecules are now available. We have performed a structural bioinformatics study of peptide- HLA complexes to derive features that generate recognition specificity, useful for guiding the design process.

Structural superposition of MHC Class I alleles
Structural superposition of MHC Class I alleles
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