Chandra:SE 302

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(Syllabus)
(Reading)
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===Reading===
===Reading===
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*Mount DW, Bioinformatics - Sequence and Genome Analysis, Cold Spring Harbor Laboratory Press, 2001.
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*Mount DW, Bioinformatics - Sequence and Genome Analysis, 2nd Edition, Cold Spring Harbor Laboratory Press, 2004. [http://www.amazon.com/gp/product/0879697121/ '''ISBN: 0879697121''']
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*Mannhold R, Kubinyi H, Timmerman H (Editors), Bioinformatics - From Genomes to Drugs Vol.I & II, Wiley - VCH, 2002
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*Mannhold R, Kubinyi H, Timmerman H (Editors), Bioinformatics - From Genomes to Drugs Vol.I & II, Wiley - VCH, 2002 [http://www.amazon.com/gp/product/3527299882/ '''ISBN: 3527299882''']
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*Flower, D R (Editor), Drug Design - cutting edges approaches, Royal Society of Chemistry, 2002.
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*Flower, D R (Editor), Drug Design - cutting edges approaches, Royal Society of Chemistry, 2002. [http://www.amazon.com/gp/product/0854048162/ '''ISBN: 0854048162''']

Revision as of 05:29, 14 December 2005

SE 302: Computational Approaches to Drug Discovery

Syllabus

  • Introduction to the process of drug and vaccine discovery,
  • Principles of drug action,
  • Drug and target structures,
  • Brief introduction to systems biology, pharmacology and chemoinformatics,
  • Use of genomics and proteomics for understanding diseases at the molecular level,
  • Sequence-structure-function relationship in proteins,
  • Strategies for target identification and validation,
  • Protein structure prediction,
  • Molecular modeling protein-ligand interactions,
  • Structure-based ligand design,
  • Lead identification, design and lead optimization,
  • Challenges in drug and vaccine discovery,
  • Relevant algorithms and topics from current literature.

Reading

  • Mount DW, Bioinformatics - Sequence and Genome Analysis, 2nd Edition, Cold Spring Harbor Laboratory Press, 2004. ISBN: 0879697121
  • Mannhold R, Kubinyi H, Timmerman H (Editors), Bioinformatics - From Genomes to Drugs Vol.I & II, Wiley - VCH, 2002 ISBN: 3527299882
  • Flower, D R (Editor), Drug Design - cutting edges approaches, Royal Society of Chemistry, 2002. ISBN: 0854048162
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