Chenlab

Chen Laboratory

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We are a computational biology laboratory interested in the following area:

• Develop bioinformatics technologies to gain novel biomedical insight into high throughput sequencing data, including the genome, epigenome, and transcriptome data.
• Study transcriptional regulation mechanisms in (1) normal cell identity determination and (2) cancer development based on cutting-edge bioinformatics technologies in combination with molecular, cellular, and animal experiments.

Recent news:

March, 2017:

• We become a member of the NCI-Funded Interdisciplinary Approaches to Cancer Metastasis Workshop, and will work together with workshop to develop highly innovative and collaborative projects on cancer metastasis.
• An R01 grant application is awarded (scored at 2%ile), we are proud to help generating part of the preliminary data. Kaifu and Dongyu will continue to help our collaborator on this project as a co-investigator and postdoc, respectively. Great job!
• An manuscript was accepted by Elife. Alin and Kaifu are proud to help our collaborator interpret the 17 sets RNA-Seq data. Cheers!

February, 2017:

• A manuscript is accepted by the Nature Chemical Biology journal, Jie conducted the RNA-Seq analysis for this project. Cheers!

January, 2017:

• Dr. Guangyu Wang from Beijing Institute of Genomiocs will join us as a postdoc soon, welcome!
• Ms. Karen Lai from UT Austin will be an undergraduate intern in our lab this summer, welcome!

December, 2016:

• A manuscript is accepted by the Science journal, Kaifu helps supervising the MNase-Seq and ChIP-Seq analysis and is a co-author. Cheers!

November, 2016:

• Alin will start his tenure-track faculty position (assistant professor of statistics) at the Manhattan College. Congratulations!
• Bo has joined the lab. Welcome onboard!

September, 2016

• A manuscript is accepted to the Journal of the American Heart Association, Jie and Kaifu are co-authors, cheers!
• A manuscript is accepted to the Nucleic Acids Research, Kaifu is a co-author, cheers!
• Dr. Qingshu Meng will be visiting us for 1 year. Dr. Meng has outstanding background in Genomics research, and is a group leader at Beijing Institute of Genomics. Welcome!

August, 2016

• Kaifu will be an adjunt assistant professor of Texas A&M.
• Dr. Bo Xia from Georgia Tech will join us as a fresh postdoc soon. Dr. Xia is a PhD of biology and Master of computer science. Welcome!

April, 2016

• Jie's paper was accepted by Molecular Cell, congratulations!

April, 2016

• New postdoc position opening.
• Jie's co-first authorship manuscript is under revision at Molecular Cell (IF 14), fingers crossed!

December, 2015

• Kaifu's new manuscript was accepted to the Nucleic Acids Research, thank Alin for his help with the revision work!
• A manuscript was accepted to the Molecular and Cellular Biology, thank Dongyu for his help with the revision work!

November, 2015

• Dr. Jie Lu has joined us as postdoctoral Fellow, welcome onboard!

October, 2015

• Dr. Dongyu Zhao has joined us as postdoctoral Fellow, welcome onboard!

September, 2015

• Our Broad H3K4me3 research work is highlighted by the Cancer Discovery journal (IF 20.26)
• Dr. Alin Tomonaga has joined us as postdoctoral Fellow, welcome onboard!

August, 2015

• Kaifu's data-revisiting paper is accepted to Nature Genetics, we find that conserved broad H3K4me3 uniquely marks tumor suppressor in normal cell types.
• Kaifu's new manuscript is under the 3rd round review at Nature Genetics now.
• Kaifu's MeCP2 mCH-binding paper (with Dr. Zoghbi lab) has been accepted to PNAS.

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