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Welcome to the '''Chien lab''' at the '''University of Massachusetts, Amherst''' in the '''Department of Biochemistry and Molecular Biology'''. <br>
Welcome to the '''Chien lab''' at the '''University of Massachusetts, Amherst''' in the '''Department of Biochemistry and Molecular Biology'''. <br>


We are an interdisciplinary lab focused on understanding regulated protein degradation and quality control using biochemistry, structural biology and cell biology.  Our primary approach is to use both molecular and cellular techniques to understand the mechanisms that lead to specific substrate processing during basic cellular events.  We draw from several fields, including '''Microbiology''' and '''Biochemistry''', and are always interested in enthusiastic students who are driven to understand fundamental biological questions.  We are part of the MCB graduate program [http://www.bio.umass.edu/mcb/], the Chemistry-Biology Interface Program [http://www.umass.edu/cbi/], and the Institute for Cellular Engineering [http://www.umass.edu/ice/] here at UMass. Please see the other links above for more detailed information, or feel free to email if you have questions that aren't addressed.
We are an interdisciplinary lab focused on understanding regulated protein degradation and quality control using biochemistry, structural biology and cell biology.  Our primary approach is to use both molecular and cellular techniques to understand the mechanisms that lead to specific substrate processing during basic cellular events.  We draw from several fields, including '''Biochemistry'''[http://www.biochem.umass.edu/] and '''Microbiology''' [http://www.bio.umass.edu/micro/], and are always interested in enthusiastic students who are driven to understand fundamental biological questions.  We are part of the MCB graduate program [http://www.bio.umass.edu/mcb/], the Chemistry-Biology Interface Program [http://www.umass.edu/cbi/], and the Institute for Cellular Engineering [http://www.umass.edu/ice/] here at UMass. Please see the other links above for more detailed information, or feel free to email if you have questions that aren't addressed.
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'''Lab Highlights''' <br>
'''Lab Highlights''' <br>
September 3, 2010. '''Claudine Mapa''' has received a Commonwealth College Research FellowshipCongratulations Claudine!! <br>
 
September 17, 2010.  '''Jing Liu''' and '''Keith Ballard''', both MCB graduate students, are rotating in the lab. Welcome Jin and Keith! <br>
Fall, 2016.  Lots of things happening! <br>
October 1, 2010.  '''Laura Francis''' has just joined the lab as a postdoctoral scholarWelcome Laura! <br>
*Joanne Lau graduated in May of 2016 - We wish her the best! <br>
December 24, 2010. '''Joanne Lau''' was just awarded a very competitive CBI TraineeshipHuge Congratulations Joanne!<br>
*Rilee Zeinert passed his ORPs and is officially a 3rd year PhD student! <br>
*Rob Vass and Rilee Zeinert co-authored a Current Opinion in Microbiology! <br>
*Madeleine Sutherland joined the lab as a research technician. Welcome Madeleine! <br>
*Liam Fitzgerald and Jake Nascembeni joined as undergraduate researchers. Welcome! <br>
 
October, 2015. Kamal's new paper was just published in Cell.  Congrats Kamal!<br>
 
http://www.cell.com/cell/abstract/S0092-8674(15)01192-7 <br>
 
You can read the paper for free (until Nov 27) here: <br>
 
http://authors.elsevier.com/a/1Rq~EL7PXI79N <br>
 
June, 2015.  Joanne's paper published in Molecular Cell! Congratulations Joanne: http://authors.elsevier.com/a/1RIVl3vVUOvQni <br>
January, 2015. Jing's collaborative work with Kearns Lab (IU) is published in PNAS. Congrats! <br>
September, 2014.  Our collaborative paper with the Ryan lab on CtrA degradation was published at PNAS. Congratulations '''Kamal Joshi'''! Check out:  [http://www.umass.edu/newsoffice/article/knowing-how-bacteria-take-out-trash-could]<br>
June, 2014. Our collaborative paper with the Shapiro lab on FtsZ/A degradation was accepted at Molecular Microbiology. Congratulations '''Nowsheen Bhat''' on her work for that! [http://www.ncbi.nlm.nih.gov/pubmed/24989075] <br>
June, 2014. '''Rob Vass''' was awarded a CBI fellowship! Congratulations Rob! <br>
June, 2014. '''Lisa Hernandez Alicea''' joins the lab! Welcome Lisa! <br>
June, 2014. Temi is joined the lab as a SPUR studentWelcome Temi! <br>
June, 2014. Carlos is working in the lab as an REU student. Welcome Carlos! <br>
November 5, 2013. '''Rob Vass''' published his work in DnaX partial processing in PNASCongrats Rob! [http://www.ncbi.nlm.nih.gov/pubmed/24145408] <br>
August 1, 2013. '''Jing Liu''' is a co-author on our newly published Cell paper with the Laub Lab.Paper is available '''here''' [http://www.cell.com/abstract/S0092-8674(13)00773-3].  Congrats Jing and Kristina! <br>
May 7, 2013.  '''Nowsheen Bhat's''' ClpP trapping paper is published in Molecular Microbiology!  Congratulations Nowsheen, Rob, Patrick, and Brian! <br>
January 29, 2013.  '''Amber Cantin's''' paper (in collaboration with the Laub Lab at MIT) was accepted at Molecular Microbiology! Congrats Amber! <br>
January 15, 2013.  '''Paula Muhlnickel''' returned to Ruhr University for the remainder of her Master's Diploma - We will miss you! <br>
December 12, 2012'''Ying Zhang''' was awarded a Commonwealth College Honors Research Grant! Congrats Ying! <br>
December 3, 2012. '''Jing Liu''' was awarded a CBI Training FellowshipCongrats Jing! <br>
August 30, 2012.  '''Amber Cantin''' graduated with her Master's and accepted a job at NIBR, Cambridge. <br>
June 15, 2012.  '''Amber Cantin''' won one of two '''Best Poster''' prizes at the Annual UMass Amherst/Worcester Biochemistry Retreat.  Congrats Amber! <br>
June 7, 2012.  Keith Rood's paper on structural aspects of PdeA degradation was published online in Structure.  Check out the '''press release''' [http://www.umass.edu/loop/content/biochemists-id-crucial-recognition-tag-cellular-‘garbage-disposal’].  The paper is available '''here''' [http://www.cell.com/structure/abstract/S0969-2126(12)00178-5]. <br>
<br>
<br>
May 3, 2011.  '''Patrick Stoddard''' was awarded an HHMI Summer Research Internship.  Congratulations Patrick! <br>
May 11, 2012.  '''Claudine Mapa''', '''Patrick Stoddard''', and '''Marty Susskind''' graduatedClaudine's headed to UMass Worcester for grad schoolPatrick's off to HarvardMarty's going to go tear up the west coast! Best of luck Guys! <br>
May 3, 2011.  '''Claudine Mapa''' was awarded a Jessica Hayes Scholarship for her academic achievements and service to the community.  Congrats Claudine! <br>
 
September 1, 2011.  '''Keith Rood''' was awarded his Masters for his thesis on adaptor mediated degradation by ClpXP.  We'll miss you Keith! <br>
September 1, 2011. '''Laura Francis''' joined the UMass Biology Department as a lecturerCongratulations Laura - come by often! <br>
September 19, 2011. '''Kamal Kishore Jamal''', MCB student, is rotating in the lab for the FallWelcome Kamal! <br>
September 19, 2011. '''Ying Zhang''' and '''Daniel DiCorpo''' are new undergraduates in the lab. Welcome Ying and Daniel! <br>
September 19, 2011. '''Siddheshwari Advani''', MCB student, is rotating in the lab for the Fall.  Welcome Sid! <br>
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Latest revision as of 04:31, 21 September 2016

Home        Contact        Internal        Lab Members        Publications        Research        Talks       


Welcome to the Chien lab at the University of Massachusetts, Amherst in the Department of Biochemistry and Molecular Biology.

We are an interdisciplinary lab focused on understanding regulated protein degradation and quality control using biochemistry, structural biology and cell biology. Our primary approach is to use both molecular and cellular techniques to understand the mechanisms that lead to specific substrate processing during basic cellular events. We draw from several fields, including Biochemistry[1] and Microbiology [2], and are always interested in enthusiastic students who are driven to understand fundamental biological questions. We are part of the MCB graduate program [3], the Chemistry-Biology Interface Program [4], and the Institute for Cellular Engineering [5] here at UMass. Please see the other links above for more detailed information, or feel free to email if you have questions that aren't addressed.

Lab Highlights

Fall, 2016. Lots of things happening!

  • Joanne Lau graduated in May of 2016 - We wish her the best!
  • Rilee Zeinert passed his ORPs and is officially a 3rd year PhD student!
  • Rob Vass and Rilee Zeinert co-authored a Current Opinion in Microbiology!
  • Madeleine Sutherland joined the lab as a research technician. Welcome Madeleine!
  • Liam Fitzgerald and Jake Nascembeni joined as undergraduate researchers. Welcome!

October, 2015. Kamal's new paper was just published in Cell. Congrats Kamal!

http://www.cell.com/cell/abstract/S0092-8674(15)01192-7

You can read the paper for free (until Nov 27) here:

http://authors.elsevier.com/a/1Rq~EL7PXI79N

June, 2015. Joanne's paper published in Molecular Cell! Congratulations Joanne: http://authors.elsevier.com/a/1RIVl3vVUOvQni
January, 2015. Jing's collaborative work with Kearns Lab (IU) is published in PNAS. Congrats!
September, 2014. Our collaborative paper with the Ryan lab on CtrA degradation was published at PNAS. Congratulations Kamal Joshi! Check out: [6]
June, 2014. Our collaborative paper with the Shapiro lab on FtsZ/A degradation was accepted at Molecular Microbiology. Congratulations Nowsheen Bhat on her work for that! [7]
June, 2014. Rob Vass was awarded a CBI fellowship! Congratulations Rob!
June, 2014. Lisa Hernandez Alicea joins the lab! Welcome Lisa!
June, 2014. Temi is joined the lab as a SPUR student. Welcome Temi!
June, 2014. Carlos is working in the lab as an REU student. Welcome Carlos!
November 5, 2013. Rob Vass published his work in DnaX partial processing in PNAS. Congrats Rob! [8]
August 1, 2013. Jing Liu is a co-author on our newly published Cell paper with the Laub Lab.Paper is available here [9]. Congrats Jing and Kristina!
May 7, 2013. Nowsheen Bhat's ClpP trapping paper is published in Molecular Microbiology! Congratulations Nowsheen, Rob, Patrick, and Brian!
January 29, 2013. Amber Cantin's paper (in collaboration with the Laub Lab at MIT) was accepted at Molecular Microbiology! Congrats Amber!
January 15, 2013. Paula Muhlnickel returned to Ruhr University for the remainder of her Master's Diploma - We will miss you!
December 12, 2012. Ying Zhang was awarded a Commonwealth College Honors Research Grant! Congrats Ying!
December 3, 2012. Jing Liu was awarded a CBI Training Fellowship! Congrats Jing!
August 30, 2012. Amber Cantin graduated with her Master's and accepted a job at NIBR, Cambridge.
June 15, 2012. Amber Cantin won one of two Best Poster prizes at the Annual UMass Amherst/Worcester Biochemistry Retreat. Congrats Amber!
June 7, 2012. Keith Rood's paper on structural aspects of PdeA degradation was published online in Structure. Check out the press release [10]. The paper is available here [11].

May 11, 2012. Claudine Mapa, Patrick Stoddard, and Marty Susskind graduated! Claudine's headed to UMass Worcester for grad school. Patrick's off to Harvard. Marty's going to go tear up the west coast! Best of luck Guys!