Chris Rhodes Week 7: Difference between revisions
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#CCR5: | #CCR5: | ||
#Epitope: | #Epitope: | ||
#Antihapten Antibody: | |||
#MN viral Sequence: | |||
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==Outline== | |||
== | ==Important Quotes== | ||
*We have been investigating several HIV-1 neutralizing antibodies and their complexes with V3 peptides in order to determine the tertiary conformation of the V3 loop and to understand why some antibodies are viral-specific while others recognize many different viral strains. | |||
*Knowledge of the conformation of this loop may help to explain coreceptor usage and the changes that take place in the virus upon conversion from a primary M-tropic isolate to the T-tropic strains associated with disease progression | |||
*Recent studies using intact viral particles rather than soluble monomeric gp120, however, indicate that V3 neutralizing antibodies may also prevent the binding of HIV-1 to CD4+ human cells [25] | |||
*Fab 58.2, a highly potent and broadly neutralizing antibody that has been reported to neutralize both T-tropic and M-tropic viral strains, as well as several strains that have been passaged only once or twice | |||
Revision as of 14:35, 12 October 2011
The paper we are preparing is "Dual conformations for the HIV-1 gp120 V3 loop in complexes with different neutralizing Fabs" Stanfield et al. (1999) The full article can be found here Stanfield (1999)
10 Terms
- Chemokine:
- Macrophage:
- Syncytia:
- Principle Neutralizing Determinant:
- CXCR4:
- CCR5:
- Epitope:
- Antihapten Antibody:
- MN viral Sequence:
Outline
Important Quotes
- We have been investigating several HIV-1 neutralizing antibodies and their complexes with V3 peptides in order to determine the tertiary conformation of the V3 loop and to understand why some antibodies are viral-specific while others recognize many different viral strains.
- Knowledge of the conformation of this loop may help to explain coreceptor usage and the changes that take place in the virus upon conversion from a primary M-tropic isolate to the T-tropic strains associated with disease progression
- Recent studies using intact viral particles rather than soluble monomeric gp120, however, indicate that V3 neutralizing antibodies may also prevent the binding of HIV-1 to CD4+ human cells [25]
- Fab 58.2, a highly potent and broadly neutralizing antibody that has been reported to neutralize both T-tropic and M-tropic viral strains, as well as several strains that have been passaged only once or twice
