Our long-term goal is to elucidate how gene regulatory networks (GRNs) control the molecular and cellular mechanisms underlying developmental cell behavior during embryogenesis. To this aim, our lab will study the transcriptional control of cellular processes underlying precardiac mesoderm cell migration in ascidian embryos.
The transcription-migration interface
. bilateral pairs of migrating trunk ventral cells (TVCs) overlaid on cell-specific transcription profiles.
Ascidian embryos provide an attractive model system to study these questions, thanks to their relative simplicity, ease of (see for example the manipulation) and extensive resources available through user-friendly web interfaces. Moreover, ascidians are among the closest living relatives to vertebrates, thus providing a unique opportunity to investigate the cellular and molecular basis for chordate development in a simple system.
please send resume to Lionel Christiaen (lionelchristiaen at berkeley dot edu). Letters of reference, statement of research interests and long-term goals will be appreciated.