Cihan Tastan: Difference between revisions

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Revision as of 00:53, 18 July 2010

I am a new member of OpenWetWare!

Contact Info

Life Lives In The Details But The Details Are Around Universe

Cihan Tastan

Life lives in details!

  • Major Department: Molecular Biology and Genetics
  • Minor Department: Computer Engineering
  • Middle East Technical University
Team in Cell!
Team in Cell!

Research Interest

Infact, the real "Interest"ing issue is the ability to look into small pretty eyes of a cancer child!

  1. Virology and Cancer Relationship
  2. Synthetic Biology
  3. Bioinformatics

My Dilemmas

One day, I will handle all my dilemmas!

- [1] (Codon) Bias to Virus: During transfection of viruses to host cells, ı wonder that whether virus genome replication exposes to codon bias (codon preferences). If there is such a case for replication of viruses within the host cells, then can we modify this property to use it against the inflammation by viruses. That is, by developing perfectly the host cell against the virus, so the virus would not be able to replicate due to codon preferences. Of course, during such a modification within the host cell, we have to pay attantion Engineered codon biases not to affect normal expression of host proteins.

- [2] Brat Transcription: I wonder that can Transcription take place during Replication? Because of that timeless and interesting replication event, ı named this case as Brat...

- [3] Sonic Energy Synthesis: Maybe one day energy producing pathway can be reengineered so that we can produce energy from sound, especially from vibrating particles, as photosynthesis, oxidative phosphorylation and nitrogen fixation...

- [4] Plasmid PCR: I want to be able to perform plasmid multiplication through PCR reaction as in proliferation of linear DNA fragments. Replication ways of different species can be searched to find appropriate enzymes for Plasmid PCR. Therefore, overnight waiting is removed and extra material used for transformation can be disappeared so on...

My Pitfall

Indeed,I know that we do not know any thing about life rather than we know!

- Bias to Virus in bacteria: Normally, interferon allow communication between cells to trigger the protective defenses of the immune system that eradicate pathogens or tumors. They increase the ability of uninfected host cells to resist new infection by virus in multicellular organisms. From this phenomenon, ı have thought that can we simulate this like communication within a bacterial culture with an viral infection? That is, with viral infection to bacteria, it will trigger a programmed cell death, leading to further propagation of virus in bacterial culture. With the help of such a project, ı thought that some viral dieases propagating in bacterial culture can be prevented. After some research, ı and my friends -E.Kalyoncu and F.Guzey- have found that a mazEF-mediated death pathway can act as a defense mechanism that prevents the spread of bacterial phage infection, allowing bacterial populations to behave like multicellular organisms in a study performed in 2005 by Hanna Engelberg-Kulka et al. published in Journal of Cell Science. In other words, such an synthetic biology mixed viral infection project exists naturally in bacteria.

Competitions & Meetings

- The 1st Bio:Fiction Science, Art & Filmfestival aims at attracting public awareness to synthetic biology and its ramifications for our daily life in the future http://www.bio-fiction.com

- COMPETITION DESCRIPTION: PREDICT HIV PROGRESSION aims to do this by having contestants find markers in the HIV sequence which predict a change in the severity of the infection (as measured by viral load and CD4 counts). http://kaggle.com/hivprogression

Suggested Podcasts

- Synthetic Biology Online: A podcast series designed to educate both the layman and professionals about synthetic biology by Eric Ma from University of British Columbia: http://www.ericmajinglong.com/synbiopodcast/

- This Week in Virology(TWIV): A weekly netcast about viruses - the kind that make you sick. Vincent Racaniello and Dickson Despommier, science Professors from Columbia University, deconstruct viruses, how they cause illness, and how you can prevent infections: http://www.twiv.tv/

Studies when Undregraduate at METU

In fact, World is a Game, a Toy and an Amusement

Awards

- METU_GENE iGEM 2009 Team was Silver Medal Winner with "Wound Dressing" Project.Look: http://2009.igem.org/Team:METU-Gene

- National Molecular Biology And Genetics Semposium at Ege University 2008 Scientific Film Competition Bronz Award : http://www.dnatube.com/video/1362/Conversion-of-blood-groups

Presentations :

Oral

[1]Tastan C. & Is O. Introduction to synthetic biology and theoretical information about Our IGEM team pojects and organization. Istanbul Technical University, Istanbul, Turkey, 17-20 August 2009

[2]Tastan C. Is O. Guzey F& Oz, T Wound Dressing: Designing a controlled release system composed biomaterials and releasing human growth factors in a way that fasten the normal healing process. International Genetically Engineered Machine Competition 2009 at Massachusetts Institute Of Technology, Cambridge, Boston, MA, USA, 28 October-2 November 2009

Poster

[1]Tastan C. & Is O. Wound Dressing: Designing a controlled release system composed biomaterials and releasing human growth factors in a way that fasten the normal healing process. International Genetically Engineered Machine Competition 2009 at Massachusetts Institute Of Technology, Cambridge, Boston, MA, USA, 28 October-2 November 2009

Publications(Private Research)

  1. DüNyA artık DNA! 16 May 2010 [1]

    [1]

  1. Zaman Makinesinin Olasiligi ve Imkansizligi 17 Feb. 2009 [1]

    [2]

  1. Ya Mars'ta yaşamaya mecbur kalırsak? 16 Feb. 2009 [1]

    [3]

  1. Arıların Yok Olması ve Hayatın Sonu 28 June 2008 [1]

    [4]

@ Magazine

  1. DüNyA artık DNA! @ Bilimsel Makaleler Haberler Temmuz 1[1]

    [1]

  1. iGEM: Genç Genetik Mühendisleri ve Sentetik Biyoloji Projeleri Yarışıyor! @ ODTÜLÜ Dergisi Haziran 2010 [1]

    [2]

<biblio>

[3 Ya Marsta yaşamaya mecbur kalırsak? Makaleler Ağustos 2009[1]




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