CircDesigNA: Difference between revisions
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(New page: This article discusses the nucleic acid sequence design program created to build DNA circuits, CircDesigNA. ===Availability=== CircDesigNA is available for use at [http://cssb.utexas.edu...) |
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===Availability=== | ===Availability=== | ||
CircDesigNA is available for | CircDesigNA is available for download from [http://sourceforge.net/projects/circdesigna this website]. | ||
Tutorials are available at [[Biomod/2011/UTAustin/Hook'em Hybridizers/CircDesigNA/Help|this website]] | Tutorials are available at [[Biomod/2011/UTAustin/Hook'em Hybridizers/CircDesigNA/Help|this website]] | ||
===What it does=== | ===What it does=== | ||
Starting with a specification of a DNA nanodevice, i.e. [[Biomod/2011/UTAustin/Hook'em Hybridizers:Simulation | something like this]], | |||
CircDesigNA attempts to assign DNA sequence to the parts of the device in a way that satisfies the user's design constraints and minimizes undesired sequence interactions. | |||
CircDesigNA employs a genetic algorithm to optimize an objective function which scores a sequence assignment on specificity of interactions. This objective function is described as follows: | CircDesigNA employs a genetic algorithm to optimize an objective function which scores a sequence assignment on specificity of interactions. This objective function is described as follows: | ||
[[Image:CircDesignaFunction.png|540px|CircDesigNA Score Function]] | [[Image:CircDesignaFunction.png|540px|CircDesigNA Score Function]] | ||
Latest revision as of 09:56, 9 August 2013
This article discusses the nucleic acid sequence design program created to build DNA circuits, CircDesigNA.
Availability
CircDesigNA is available for download from this website.
Tutorials are available at this website
What it does
Starting with a specification of a DNA nanodevice, i.e. something like this, CircDesigNA attempts to assign DNA sequence to the parts of the device in a way that satisfies the user's design constraints and minimizes undesired sequence interactions.
CircDesigNA employs a genetic algorithm to optimize an objective function which scores a sequence assignment on specificity of interactions. This objective function is described as follows:
