Crisanti:Nolan

Position

Research Fellow

Department of Biological Sciences
Sir Alexander Flemming Building

Email: t.nolan@imperial.ac.uk

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Research Interests

• Applying molecular biology to vector control with the aim of reducing malaria transmission

Education

B.Sc. Imperial College London

PhD: Imperial College London
Post-doc: University of Rome: With Carlo Cogoni on endogenous mechanisms and roles for post-transcriptional gene silencing
Post-doc: UCL: With David Gems on mechanisms of ageing

Publications

Thompson FJ, Barker GL, Nolan T, Gems D, Viney ME.Transcript profiles of long- and short-lived adults implicate protein synthesis in evolved differences in ageing in the nematode Strongyloides ratti. Mech Ageing Dev. 2009 Mar;130(3):167-72.
Nolan T, Cecere G, Mancone C, Alonsi T, Tripodi M, Catalanotto C, Cogoni C. The RNA-dependent RNA polymerase essential for post-transcriptional gene silencing in Neurospora crassa interacts with Replication Protein A. Nucleic Acids Res. 2008 Feb;36(2):532-8.
Nolan T*, Scali C*, Sharakhov I, Sharakhova M, Crisanti A, Catteruccia F. Post-integration behavior of a Minos transposon in the malaria mosquito Anopheles stephensi. Mol Genet Genomics. 2007 Jul 19;
Catalanotto C, Nolan T, Cogoni C. Homology effects in Neurospora crassa. FEMS Microbiol Lett. 2006 Jan;254(2):182-9.
Lombardo F, Nolan T, Lycett G, Lanfrancotti A, Stich N, Catteruccia F, Louis C, Coluzzi M, Arcà B. An Anopheles gambiae salivary gland promoter analysis in Drosophila melanogaster and Anopheles stephensi. Insect Molecular Biology 2005, 14 (2), 207–216
Nolan T, Braccini L, Azzalin, De Toni A, Macino G, Cogoni C. The post-transcriptional gene silencing machinery functions independently of DNA methylation to repress a LINE1-like retrotransposon in Neurospora crassa. Nucleic Acids Research 2005 Mar 14;33(5):1564-73.
Nolan T, Cogoni C. The long hand of the small RNAs reaches into several levels of gene regulation. Biochem Cell Biol. 2004 Aug;82(4):472-81.
Moreira LA, Ito J, Ghosh A, Devenport M, Zieler H, Abraham EG, Crisanti A, Nolan T, Catteruccia F, Jacobs-Lorena M. Bee venom phospholipase inhibits malaria parasite development in transgenic mosquitoes. J Biol Chem. 2002 Oct 25;277(43):40839-43
Nolan T, Bower TM, Brown AE, Crisanti A, Catteruccia F. piggyBac-mediated germline transformation of the malaria mosquito Anopheles stephensi using the red fluorescent protein dsRED as a selectable marker. J Biol Chem. 2002 Mar 15;277(11):8759-62.
Catteruccia F*, Nolan T*, Loukeris TG, Blass C, Savakis C, Kafatos FC, Crisanti A. Stable germline transformation of the malaria mosquito Anopheles stephensi. Nature. 2000 Jun 22;405(6789):959-62. (* joint first authors)
Catteruccia F, Nolan T, Blass C, Muller HM, Crisanti A, Kafatos FC, Loukeris TG. Toward Anopheles transformation: Minos element activity in anopheline cells and embryos. Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2157-62.

• joint first author