Critical micelle concentration (CMC)
Critical micelle concentration (CMC) is defined as the concentration of detergents above which micelles are spontaneously formed. The CMC is important in biology because at concentrations above it the detergents form complexes with lipophilic proteins. Below this borderline, detergents merely partition into membranes without solubilising membrane proteins.
|Detergent||CMC (%w/v)||CMC (mM)||MW||Type|
Note: The molecular weights for some detergents are average values. Triton X-100, for example, can range between 600 and over 650 MW depending on synthesis. The exact molecular weight influences the CMC.
Note: Saponin is a class of amphiphilic, natural metabolites with detergent properties often extracted from plants. CMC may vary.
- new, abbreviated Detergent guide, Calbiochem
- Commonly used detergents, Frost lecture, UFL
- Urum et al 2004, incl. data on saponin